Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

1995 • 301 citations

Molecular basis and prenatal diagnosis of beta-thalassemia

1988 • 248 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

1996 • 217 citations

The Molecular Basis of Leukemia

1994 • 210 citations

Mutation of the MXI1 gene in prostate cancer

1995 • 207 citations

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

1984 • 204 citations

Molecular basis and prenatal diagnosis of beta-thalassemia

1988 • 197 citations

Does activation of the TAL1 gene occur in a majority of patients with T- cell acute lymphoblastic leukemia? A pediatric oncology group study

1995 • 163 citations

Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia

1986 • 160 citations

Genetic steps in colorectal cancer

1994 • 132 citations

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.

1995 • 125 citations

A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis

1995 • 91 citations

Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice

1995 • 70 citations

Genetic instability of microsatellites in hematological neoplasms.

1995 • 64 citations

The two isoforms of mouse terminal deoxynucleotidyl transferase differ in both the ability to add N regions and subcellular localization.

1995 • 52 citations

scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice.

1995 • 48 citations

T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice

1989 • 44 citations

Expression of the proto-oncogene rhombotin-2 is identical to the acute phase response protein metallothionein, suggesting multiple functions.

1995 • 16 citations