Trophic Actions of IGF-I, IGF-II and Insulin on Cholinergic and Dopaminergic Brain Neurons

Trophic factors and neuronal survival

1989 • 1,631 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain

1986 • 659 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

1987 • 558 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures

1982 • 291 citations

In vitro maturation of mesencephalic dopaminergic neurons from mouse embryos is enhanced in presence of their striatal target cells.

1979 • 273 citations

Neurotrophic molecules

1989 • 270 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Neurotrophic Factors

1985 • 230 citations

Insulin-Mediated Regulation of Neuronal Maturation

1984 • 184 citations

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

1988 • 179 citations

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

1985 • 174 citations

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

1982 • 166 citations

Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex

1989 • 149 citations

Basic fibroblast growth factor promotes In vitro survival and cholinergic development of rat septal neurons: Comparison with the effects of nerve growth factor

1989 • 142 citations

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

1987 • 132 citations

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

1988 • 122 citations

Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potein inhibitor of insulin receptor than IGF-I receptor

1988 • 121 citations

NGF effects on developing forebrain cholinergic neurons are regionally specific

1987 • 120 citations

Ontogeny of Receptors for Insulin-Like Peptides in Chick Embryo Tissues: Early Dominance of Insulin-Like Growth Factor over Insulin Receptors in Brain*

1985 • 116 citations

Nerve growth factor selectively increases cholinergic markers but not neuropeptides in rat basal forebrain in culture

1987 • 113 citations

Chapter 15 Brain derived neurotrophic factor

1987 • 94 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 94 citations

Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

1982 • 89 citations

Effect of Prior Dopamine Denervation on Survival and Fiber Outgrowth from Intrastriatal Fetal Mesencephalic Grafts

1990 • 87 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 85 citations

Effect of epidermal growth factor and insulin on DNA, RNA, and cytoskeletal protein labeling in primary rat astroglial cell cultures

1988 • 82 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

The trophic theory of neural concentrations

1986 • 77 citations

Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

1987 • 65 citations

Development of cholinergic pedunculopontine neurons in vitro: Comparison with Cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid

1988 • 57 citations

Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

1987 • 55 citations

Blockage of Nerve Growth Factor Action in PC12h Cells by Staurosporine, a Potent Protein Kinase Inhibitor

1989 • 55 citations

Septal cholinergic neurons from postnatal rat can survive in the dissociate culture conditions in the presence of nerve growth factor

1987 • 50 citations

Insulin dependent neurite outgrowth in cultured embryonic mouse brain cells

1983 • 48 citations

Scopolamine treatment and fimbria-fornix lesions: Mimetic effects on radial maze performance

1989 • 47 citations

Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells

1988 • 44 citations

Insulin-like immunoreactivity in the human brain

1982 • 40 citations

Insulin and insulin-like growth factor 1 receptors during postnatal development of rat brain

1988 • 37 citations

Release of dopamine from coaggregate cultures of mesencephalic tegmentum and corpus striatum

1983 • 30 citations

Visualization of IGF-2 Receptors in Rat Brain

1987 • 5 citations