tRNA on the Ribosome: a Waggle Theory

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

1974 • 1,532 citations

Structure of yeast phenylalanine tRNA at 3 Å resolution

1974 • 1,000 citations

Kinetic amplification of enzyme discrimination

1975 • 742 citations

Intermediate states in the movement of transfer RNA in the ribosome

1989 • 736 citations

Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures

1992 • 725 citations

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

1991 • 635 citations

INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEIN

1959 • 561 citations

The ribosome: Structure, function and evolution

1991 • 531 citations

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

1989 • 492 citations

RIBOSOMAL RNA AND TRANSLATION

1991 • 489 citations

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

1988 • 488 citations

Molecular Mechanisms of Protein Biosynthesis

1977 • 472 citations

Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes

1986 • 425 citations

Crystal structure of yeast phenylalanine transfer RNA

1978 • 375 citations

Tryptophan transfer RNA as the UGA suppressor

1971 • 362 citations

Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase

1991 • 358 citations

Crystallographic refinement of yeast phenylalanine transfer RNA at 2·5Å resolution

1976 • 315 citations

Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA

1990 • 294 citations

On the physical basis for ambiguity in genetic coding interactions.

1978 • 274 citations

Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide

1967 • 268 citations

Factor-free (“Non-enzymic”) and factor-dependent systems of translation of polyuridylic acid by Escherichia coli ribosomes

1976 • 258 citations

Studies of the complex between transfer RNAs with complementary anticodons

1976 • 233 citations

Proofreading of the codon-anticodon interaction on ribosomes.

1977 • 216 citations

Physico-chemical properties of nucleic acids

1974 • 213 citations

Structure and Conformation of Nucleic Acids and Protein-Nucleic Acid Interactions

1976 • 209 citations

Is there proofreading during polypeptide synthesis?

1982 • 207 citations

Three tRNA binding sites on Escherichia coli ribosomes.

1981 • 201 citations

Anticodon and acceptor stem nucleotides in tRNAGln are major recognition elements for E. coli glutaminyl-tRNA synthetase

1991 • 196 citations

Translational Efficiency of Transfer RNA's: Uses of an Extended Anticodon

1982 • 185 citations

EFTu provides an internal kinetic standard for translational accuracy

1988 • 176 citations

The involvement of 5S RNA in the binding of tRNA to ribosomes

1973 • 171 citations

Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA.

1991 • 171 citations

Binding of transfer ribonucleic acid to ribosomes engaged in protein synthesis: Number and properties of ribosomal binding sites

1965 • 169 citations

Translation of the UGA triplet in vitro by tryptophan transfer RNA's

1971 • 162 citations

Translocation in Protein Synthesis: A Hybrid Structure Model

1968 • 160 citations

Transfer RNA in protein synthesis

1993 • 157 citations

The role of induced fit and conformational changes of enzymes in specificity and catalysis

1988 • 155 citations

Construction of Escherichia coli amber suppressor tRNA genes

1990 • 155 citations

The allosteric three-site model for the ribosomal elongation cycle: features and future

1990 • 154 citations

Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA.

1991 • 144 citations

A semi-quantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli Evaluation of some molecular parameters of translation in vivo

1974 • 137 citations

[22] Elongation factor Tu and the aminoacyl-tRNA · EFTu · GTP complex

1974 • 128 citations

The allosteric three-site model for the ribosomal elongation cycle

1989 • 126 citations

A Model of the Functioning Ribosome: Locking and Unlocking of the Ribosome Subparticles

1969 • 124 citations

Binding of the 3′ terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation.

1989 • 119 citations

Toward a Model for the Interaction Between Elongation Factor Tu and the Ribosome

1993 • 117 citations

Sense codons are found in specific contexts

1985 • 111 citations

tRNA-tRNA interactions within cellular ribosomes.

1989 • 110 citations

Aminoacyl-tRNA binding at the recognition site is the first step of the elongation cycle of protein synthesis.

1977 • 108 citations

Quantitative study of interaction of deacylated tRNA with Escherichia coli ribosomes

1983 • 105 citations

70-S Ribosomes of Escherichia coli Have an Additional Site for Deacylated tRNA Binding

2005 • 103 citations

The accuracy of protein biosynthesis is limited by its speed: high fidelity selection by ribosomes of aminoacyl-tRNA ternary complexes containing GTP[gamma S]

1982 • 101 citations

Actions of the anticodon arm in translation on the phenotypes of RNA mutants

1986 • 94 citations

How many EF-Tu molecules participate in aminoacyl-tRNA binding and peptide bond formation in Escherichia coli translation?

1990 • 92 citations

Distance moved by transfer RNA during translocation from the A site to the P site on the ribosome

1982 • 91 citations

Allosteric mechanism for codon-dependent tRNA selection on ribosomes.

1975 • 90 citations

Allosteric interactions between the ribosomal transfer RNA-binding sites A and E.

1986 • 87 citations

Movement of tRNA but not the nascent peptide during peptide bond formation on ribosomes

1990 • 86 citations

DNA twisting and the effects of non-contacted bases on affinity of 434 operator for 434 represser

1992 • 84 citations

Mutants of the elongation factor EF-Tu, a new class of nonsense suppressors.

1985 • 82 citations

Kinetic and thermodynamic parameters for tRNA binding to the ribosome and for the translocation reaction.

1992 • 75 citations

THE SYNTHESIS OF PROTEINS UPON RIBOSOMES.

1964 • 75 citations

The Accuracy of Translation

1980 • 73 citations

Codon-anticodon interaction at the ribosomal P (peptidyl-tRNA) site

1979 • 73 citations

Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study

1990 • 70 citations

Destabilization of codon-anticodon interaction in the ribosomal exit site

1987 • 70 citations

The effect of point mutations affecting Escherichia coli tryptophan tRNA on anticodon-anticodon interactions and on UGA suppression

1984 • 70 citations

tRNA Structure and Ribosomal Function

1994 • 69 citations

Transfer RNA structure and coding specificity

1989 • 68 citations

Chemical probing of the tRNA--ribosome complex.

1981 • 66 citations

Accuracy of protein biosynthesis. A kinetic study of the reaction of poly(U)-programmed ribosomes with a leucyl-tRNA2-elongation factor Tu-GTP complex.

1982 • 66 citations

The reaction of ribosomes with elongation factor Tu.GTP complexes. Aminoacyl-tRNA-independent reactions in the elongation cycle determine the accuracy of protein synthesis.

1986 • 65 citations

Apparent association constants of tRNAs for the ribosomal A, P, and E sites.

1992 • 63 citations

How are tRNAs and mRNA arranged in the ribosome? An attempt to correlate the stereochemistry of the tRNA-mRNA interaction with constraints imposed by the ribosomal topography

1992 • 61 citations

Hydroxyl radical cleavage of tRNA in the ribosomal P site.

1992 • 61 citations

Anticodon-anticodon interaction induces conformational changes in tRNA: yeast tRNAAsp, a model for tRNA-mRNA recognition.

1986 • 60 citations

Topological arrangement of two transfer RNAs on the ribosome

1983 • 58 citations

Binding of yeast tRNAphe anticodon arm to Escherichia coli 30 S ribosomes

1983 • 58 citations

Transfer RNA structure and coding specificity

1989 • 55 citations

Pre-steady-state kinetics of ribosomal translocation

1986 • 54 citations

The translational efficiency of tRNA is a property of the anticodon arm.

1986 • 54 citations

Recessive Lethal Nonsense Suppressor in Escherichia coli which inserts Glutamine

1969 • 53 citations

Specific recognition of the 3′-terminal adenosine of tRNAPhe in the exit site of Escherichia coli ribosomes

1988 • 53 citations

Codon–anticodon interaction at the ribosomal peptidyl-site

1979 • 53 citations

Evidence for functional interaction between elongation factor Tu and 16S ribosomal RNA.

1993 • 53 citations

Codon contexts from weakly expressed genes reduce expression in vivo

1989 • 52 citations

Systematic alterations in the anticodon arm make tRNA(Glu)-Suoc a more efficient suppressor.

1987 • 52 citations

Transfer RNA selection at the ribosomal A and P sites

1979 • 50 citations

Does quantitative tRNA adaptation to codon content in mRNA optimize the ribosomal translation efficiency? Proposal for a translation system model

1981 • 47 citations

Direct localization of the tRNA-anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averaging

1988 • 46 citations

Intramolecular flexibility in phenylalanine transfer RNA

1981 • 45 citations

Comparison of Escherichia coli tRNAPhe in the Free State, in the Ternary Complex and in the Ribosomal A and P Sites by Chemical Probing

1983 • 41 citations

Construction of a composite tRNA gene by anticodon loop transplant.

1980 • 41 citations

Codon specificity of UGA suppressor tRNATrp from Escherichia coli.

1977 • 41 citations

The rate of cleavage of GTP on the binding of Phe-tRNA.elongation factor Tu.GTP to poly(U)-programmed ribosomes of Escherichia coli.

1985 • 40 citations

The conserved 5 S rRNA complement to tRNA is not required for translation of natural mRNA.

1984 • 38 citations

tRNA topography during translocation: steady-state and kinetic fluorescence energy-transfer studies

1986 • 37 citations

tRNA Structure and Ribosomal Function

1994 • 36 citations

Peptide Chain Elongation

1969 • 35 citations

tRNA tertiary structure in solution as probed by the photochemically induced 8-13 cross-link

1975 • 31 citations

Evidence from ultraviolet absorbance measurements for a codon-induced conformational change in lysine tRNA from Escherichia coli.

1979 • 31 citations

Amino acid substitutions resulting from suppression of nonsense mutations

1970 • 30 citations

Antagonistic effects of mutant elongation factor Tu and ribosomal protein S12 on control of translational accuracy, suppression and cellular growth

1988 • 30 citations

Codon discrimination and anticodon structural context.

1989 • 30 citations

The distance between the anticodon loops of two tRNAs bound to the 70 S Escherichia coli ribosome

1979 • 30 citations

Chemical Evidence for a Codon‐Induced Allosteric Change in tRNA^Lys Involving the 7‐Methylguanosine Residue 46

1979 • 30 citations

Proofreading, NTPases and translation: constraints on accurate biochemistry

1992 • 30 citations

A novel type of + 1 frameshift suppressor: a base substitution in the anticodon stem of a yeast mitochondrial serine-tRNA causes frameshift suppression.

1990 • 29 citations

Is translation inhibited by noncognate ternary complexes?

1988 • 29 citations

Comparison of the structures of free and ribosome-bound tRNAPhe by using slow tritium exchange.

1980 • 29 citations

Effect of photochemical crosslink S4U(8)-C(13) on suppressor activity of su+ tRNATrp from Escherichia coli

1979 • 27 citations

The two main states of the elongating ribosome and the role of the α-sarcin stem-loop structure of 23S RNA

1992 • 27 citations

Mechanism of ribosomal translocation

1986 • 26 citations

A consonant model of the tRNA-ribosome complex during the elongation cycle of translation

1991 • 25 citations

Codon-induced association of the isolated anticodon loop of tRNAPhe

1986 • 25 citations

Proofreading, NTPases and translation: successful increase in specificity

1992 • 25 citations

An apparent conformational change in tRNAPhe that is associated with the peptidyl transferase reaction

1987 • 23 citations

Codon-induced tRNA association: quantitative analysis by sedimentation equilibrium

1982 • 22 citations

Thermodynamics and Kinetics of Conformational Transitions in Oligonucleotides and tRNA

1973 • 22 citations

Structure investigation of Phe-tRNA^phefromE.colibound to the ribosomal A-site

1983 • 20 citations

Elongation factor Tu.guanosine 3'-diphosphate 5'-diphosphate complex increases the fidelity of proofreading in protein biosynthesis: mechanism for reducing translational errors introduced by amino acid starvation.

1986 • 20 citations

Effector region of the translation elongation factor EF-Tu.GTP complex stabilizes an orthoester acid intermediate structure of aminoacyl-tRNA in a ternary complex.

1994 • 18 citations

Mutants of su+7 tRNA include a functional tRNA with an altered TΨCG sequence

1981 • 18 citations

Construction of a Systematic Set of tRNA Mutants by Ligation of Synthetic Oligonucleotides into Defined Single-Stranded Gaps

1986 • 17 citations

Site-specific mutagenesis of Escherichia coli gltT yields a weak, glutamic acid-inserting ochre suppressor

1985 • 17 citations

Stereochemical Analysis of Ribosomal Transpeptidation, Translocation, and Nascent Peptide Folding

1986 • 16 citations

Mutation in the D arm enables a suppressor with a CUA anticodon to read both amber and ochre codons in Escherichia coli

1986 • 15 citations

Novel data on interactions of elongation factor Ts

1992 • 15 citations

A Stereochemical Model of the Transpeptidation Complex

1987 • 15 citations

The role of translocation in ribosomal accuracy. Translocation rates for cognate and noncognate aminoacyl- and peptidyl-tRNAs on Escherichia coli ribosomes.

1987 • 13 citations

Comparison of ribosomal entry and acceptor transfer ribonucleic acid binding sites on Escherichia coli 70S ribosomes. Fluorescence energy transfer measurements from Phe-tRNAPhe to the 3' end of 16S ribonucleic acid

1983 • 13 citations

Interaction of unfolded tRNA with the 3′-terminal region ofE. coli16S ribosomal RNA

1985 • 13 citations

The function of the translating ribosome: allosteric three-site model of elongation

1991 • 11 citations

Binding of UGA to wild type and suppressor Tryptophan tRNA from E. coli

1974 • 11 citations

Ribosome function determined by fluorescence

1992 • 10 citations

The bases of the tRNA anticodon loop are independent by genetic criteria

1987 • 7 citations

Conformational Change of the L-Shaped tRNA^PheMolecule

1989 • 4 citations

Low field nuclear magnetic resonance studies of the structure of UGA suppressor tryptophan tRNA from Escherichia coli; normal and photo-crosslinked species

1980 • 3 citations