Codon contexts from weakly expressed genes reduce expression in vivo

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES

1956 • 4,156 citations

Calcium-dependent bacteriophage DNA infection

1970 • 2,743 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system

1981 • 1,405 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

Codon catalog usage is a genome strategy modulated for gene expressivity

1981 • 951 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes

1981 • 858 citations

Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes

1982 • 850 citations

TRANSCRIPTION TERMINATION AND THE REGULATION OF GENE EXPRESSION

1986 • 811 citations

Translational Initiation in Prokaryotes

1981 • 785 citations

[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast

1983 • 783 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

1983 • 707 citations

Characterization of translational initiation sites inE. coli

1982 • 673 citations

Control of Transcription Termination

1978 • 618 citations

Codon usage in regulatory genes inEscherichia colidoes not reflect selection for ‘rare’ codons

1986 • 539 citations

[27] Extension inhibition analysis of translation initiation complexes

1988 • 410 citations

Translation is a non-uniform process

1984 • 387 citations

STRINGENT CONTROL IN E. COLI

1979 • 373 citations

Bacteriophage T7 early promoters: Nucleotide sequences of two RNA polymerase binding sites

1975 • 303 citations

Codon usage can affect efficiency of translation of genes inEscherichia coli

1984 • 290 citations

The influence of codon context on genetic code translation

1980 • 285 citations

Escherichia coli ribosomes translate in vivo with variable rate.

1984 • 257 citations

Pausing and attenuation of in vitro transcription in the rrnB operon of E. coli

1981 • 207 citations

Lac repressor can be fused to β-galactosidase

1974 • 206 citations

Codon Replacement in the PGK1 Gene of Saccharomyces Cerevisiae: Experimental Approach to study the role of Biased Codon Usage in Gene Expression

1987 • 198 citations

Gene function in prokaryotes

1984 • 183 citations

Compilation of tRNA sequences and sequences of tRNA genes

1987 • 165 citations

A direct effect of guanosine tetraphosphate on pausing of Escherichia coli RNA polymerase during RNA chain elongation.

1981 • 147 citations

A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control.

1979 • 143 citations

Nucleotide sequence of bacteriophage f1 DNA

1982 • 133 citations

Codon replacement in the PGK1 gene of Saccharomyces cerevisiae: experimental approach to study the role of biased codon usage in gene expression.

1987 • 132 citations

Use of tRNA suppressors to probe regulation of Escherichia coli release factor 2

1988 • 128 citations

Inefficient translation initiation causes premature transcription termination in the IacZ gene

1986 • 122 citations

RNA polymerase specificity and the control of growth

1976 • 111 citations

Sense codons are found in specific contexts

1985 • 111 citations

RNA sequence and secondary structure requiresments for rho-dependent transcription termination

1985 • 104 citations

Constraints on codon context in Escherichia coli genes their possible role in modulating the efficiency of translation

1986 • 98 citations

Sequence of promoter for coat protein gene of bacteriophage fd

1976 • 96 citations

EXCESS POLYMORPHISM AT THE Adh LOCUS IN DROSOPHILA MELANOGASTER

1986 • 90 citations

Bacteriophage MS2 RNA: A correlation between the stability of the codon: Anticodon interaction and the choice of code words

1978 • 89 citations

Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism

1986 • 87 citations

Mechanism of ribosome frameshifting during translation of the genetic code

1983 • 86 citations

Translation rate modification by preferential codon usage: Intragenic position effects

1987 • 81 citations

Properties of the Radio Continuum Emission from Interacting Galaxies

1973 • 76 citations

Regulation of the rpsU-dnaG-rpoD macromolecular synthesis operon and the initiation of DNA replication in Escherichia coli K-12

1983 • 73 citations

Contextual constraints on synonymous codon choice

1983 • 65 citations

Maximizing gene expression

1986 • 62 citations

Defined set of cloned termination suppressors: in vivo activity of isogenetic UAG, UAA, and UGA suppressor tRNAs

1984 • 59 citations

The functional stability of the lacZ transcript is sensitive towards sequence alterations immediately downstream of the ribosome binding site

1987 • 57 citations

A design for computer nucleic-acid-sequence storage, retrieval, and manipulation

1982 • 57 citations

Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase transcriptional pause sites on SV40 DNA F1

1981 • 56 citations

Tests of the ribosomal editing hypothesis: Amino acid starvation differentially enhances the dissociation of peptidyl-tRNA from the ribosome

1979 • 51 citations

Factor-independent termination of transcription in a stretch of deoxyadenosine residues in the template DNA

1987 • 46 citations

Functional analysis of lac repressor restart sites in translational initiation and reinitiation

1985 • 43 citations

Noncoordinate translation-level regulation of ribosomal and nonribosomal protein genes in the Escherichia coli trmD operon

1988 • 36 citations

Promoter selectivity ofEscherichia coliRNA polymerase: alteration by fMet-tRNA_f^Met

1986 • 33 citations

Tests of the ribosome editor hypothesis

1987 • 27 citations

Effect of rate-limiting elongation on bacteriophage MS2 RNA-directed protein synthesis in extracts of Escherichia coli

1982 • 25 citations

Contextual Constraints on Codon Pair Usage: Structural and Biological Implications

1986 • 7 citations

Modulation of the lactose operon mRNA turnover by inhibitors of dihydrofolate reductase

1978 • 5 citations