The Integration of Receptor-Regulated Intracellular Calcium Release and Calcium Entry across the Plasma Membrane

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate

1970 • 1,097 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Calcium in biological systems

1976 • 550 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

Fluorescence and bioluminescence measurement of cytoplasmic free calcium

1987 • 522 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?

1988 • 451 citations

Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle

1984 • 432 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells

1988 • 344 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Metabolism of the inositol phosphates produced upon receptor activation

1989 • 305 citations

Uptake and intracellular sequestration of divalent cations in resting and methacholine-stimulated mouse lacrimal acinar cells. Dissociation by Sr2+ and Ba2+ of agonist-stimulated divalent cation entry from the refilling of the agonist-sensitive intracellular pool.

1990 • 298 citations

Exchange characteristics of the noradrenaline‐sensitive calcium store in vascular smooth muscle cells or rabbit ear artery.

1981 • 291 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Excitation-contraction coupling and the ultrastructure of smooth muscle.

1985 • 242 citations

Stimulus-permeability coupling: role of calcium in the receptor regulation of membrane permeability.

1978 • 239 citations

Capacitative calcium entry in parotid acinar cells

1989 • 234 citations

Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization

1988 • 217 citations

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

1977 • 197 citations

A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens

1988 • 196 citations

Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells

1986 • 190 citations

Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.

1985 • 184 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues

1989 • 164 citations

Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells

1989 • 163 citations

Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate

1987 • 163 citations

Biphasic modulation of potassium release in rat parotid gland by carbachol and phenylephrine.

1976 • 153 citations

Influence of inositol 1,4,5-trisphosphate and guanine nucleotides on intracellular calcium release within the N1E-115 neuronal cell line.

1986 • 146 citations

Influx of bivalent cations can be independent of receptor stimulation in human endothelial cells

1989 • 127 citations

Nature of the receptor‐regulated calcium pool in the rat parotid gland.

1982 • 119 citations

Calcium-mobilizing receptors

1987 • 110 citations

The effects of substance P and carbachol on inositol tris- and tetrakisphosphate formation and cytosolic free calcium in rat parotid acinar cells. A correlation between inositol phosphate levels and calcium entry.

1987 • 105 citations

Formation and metabolism of [3H]inositol phosphates in AR42J pancreatoma cells. Substance P-induced Ca2+ mobilization in the apparent absence of inositol 1,4,5-trisphosphate 3-kinase activity.

1988 • 104 citations

Kinetics of inositol 1,4,5-trisphosphate and inositol cyclic 1:2,4,5-trisphosphate metabolism in intact rat parotid acinar cells. Relationship to calcium signalling.

1988 • 104 citations

Calcium in biological systems

1986 • 104 citations

Phosphoinositides and receptor mechanisms

1986 • 95 citations

Immunocytochemistry of calciosomes in liver and pancreas.

1988 • 93 citations

Inositol 1,4,5-trisphosphate and inositol 1,2-cyclic 4,5-trisphosphate are minor components of total mass of inositol trisphosphate in thrombin-stimulated platelets. Rapid formation of inositol 1,3,4-trisphosphate.

1987 • 90 citations

Receptor regulation of calcium release and calcium permeability in parotid gland cells

1981 • 89 citations

Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils.

1986 • 88 citations

Calcium and Ion Channel Modulation

1988 • 83 citations

Inositol-1,4,5-trisphosphate injection mimics fertilization potentials in sea urchin eggs

1986 • 72 citations

Control of calcium channels by membrane receptors in the rat parotid gland.

1978 • 69 citations

Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets.

1986 • 66 citations

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

1987 • 66 citations

Release and reloading of intracellular Ca stores after cholinergic stimulation of the parietal cell

1988 • 64 citations

Dependence of intracellular effects of GTPγS and inositoltrisphosphate on cell membrane potential and on external Ca ions

1987 • 63 citations

Heparin inhibits IP₃‐induced Ca²⁺ release in permeabilized pancreatic β‐cells

1988 • 57 citations

myo-Inositol 1,4,5-trisphosphate mobilizes Ca2+ from isolated adipocyte endoplasmic reticulum but not from plasma membranes

1986 • 54 citations

Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.

1987 • 45 citations

Inositol 1,3,4,5‐tetrakisphosphate increases the duration of the inositol 1,4,5‐trisphosphate‐mediated Ca²⁺ transient

1987 • 42 citations

Source of 3H-Labeled Inositol Bis- and Monophosphates in Agonist-activated Rat Parotid Acinar Cells

1989 • 41 citations

Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors

1989 • 39 citations

Inositol 1,4,5-trisphosphate-induced calcium release from platelet plasma membrane vesicles

1988 • 36 citations

Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells.

1988 • 35 citations

Transient accumulation of inositol (1,3,4,5)-tetrakisphosphate in response to α1-adrenergic stimulation in adult cardiac myocytes

1988 • 35 citations

Characterization of Ca2+ fluxes in rat liver plasma-membrane vesicles

1988 • 31 citations

The road to the phosphoinositide-generated second messengers

1987 • 30 citations

Inositol polyphosphates regulate excitability

1988 • 15 citations

Measurement of intracellular inositol 1,4,5-trisphosphate concentrations in unstimulated and vasopressin-stimulated rat hepatocytes using a novel inositol 1,4,5-trisphosphate-specific binding assay

1988 • 8 citations