Cross-priming of cytotoxic T cells promoted by apoptosis-inducing tumor cell reactive antibodies?

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

1998 • 2,777 citations

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

2000 • 2,694 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20

1994 • 1,932 citations

IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

1997 • 1,652 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Consequences of Cell Death

2000 • 1,382 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Rituximab (Anti-CD20 Monoclonal Antibody) for the Treatment of Patients With Relapsing or Refractory Aggressive Lymphoma: A Multicenter Phase II Study

1998 • 914 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma

1994 • 747 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

2001 • 601 citations

CD20: a regulator of cell-cycle progression of B lymphocytes

1994 • 583 citations

Apoptosis of Malignant Human B Cells by Ligation of CD20 With Monoclonal Antibodies

1998 • 576 citations

Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

1999 • 499 citations

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy.

1985 • 486 citations

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

1984 • 443 citations

Human immune response to multiple injections of murine monoclonal IgG.

1985 • 425 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells

2000 • 388 citations

Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas

1987 • 360 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

Clinical trials of antibody therapy

2000 • 297 citations

Processing of engulfed apoptotic bodies yields T cell epitopes.

1997 • 267 citations

Rituximab monoclonal antibody as initial systemic therapy for patients with low-grade non-Hodgkin lymphoma

2000 • 267 citations

The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium

1997 • 262 citations

Antibody humanization: a case of the ‘Emperor’s new clothes’?

2000 • 252 citations

Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells

2000 • 248 citations

Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages

1999 • 208 citations

Anti-Idiotype Antibodies Can Induce Long-Term Complete Remissions in Non-Hodgkin’s Lymphoma Without Eradicating the Malignant Clone

1998 • 173 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-gamma in establishing and maintaining the tumor-dormant state.

1999 • 142 citations

Cross‐linking of the CAMPATH‐1 antigen (CD52) mediates growth inhibition in human B‐ and T‐lymphoma cell lines, and subsequent emergence of CD52‐deficient cells

1998 • 141 citations

CD20 antibody (C2B8)-induced apoptosis of lymphoma cells promotes phagocytosis by dendritic cells and cross-priming of CD8+ cytotoxic T cells

2001 • 139 citations

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

1999 • 138 citations

Tumor-specific, cytotoxic T-lymphocyte response after idiotype vaccination for B-cell, non-Hodgkin's lymphoma

1996 • 129 citations

Signaling antibodies in cancer therapy

1999 • 127 citations

Rescue of Daudi cell HLA expression by transfection of the mouse beta 2-microglobulin gene.

1988 • 79 citations

Role of antigen-presenting cells in cross-priming of cytotoxic T lymphocytes by apoptotic cells

1999 • 38 citations

The HLA‐A,B,C genotype of the class I negative cell line Daudi reveals novel HLA‐A and ‐B alleles

1995 • 28 citations

Relationship between autoimmunity and immunodeficiency in CLL

1997 • 19 citations

Advances in immunotherapy of hematologic malignancies

1998 • 17 citations

Dr. William Dameshek: A Biographical Comment

1960 • 6 citations