Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal Translocation

1988 • 292 citations

Recombinant 25‐kDa CD23 and interleukin 1α promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis

1991 • 264 citations

Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

1991 • 222 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms

1991 • 174 citations

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1990 • 147 citations

Effect of fixation time and microwave oven heating time on retrieval of the Ki-67 antigen from paraffin-embedded tissue.

1993 • 136 citations

Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein

1994 • 100 citations

Investigations of Antisense Oligonucleotides Targeted Againstbcl-2RNAs

1993 • 95 citations

A new human B-cell non-Hodgkin's lymphoma cell line (Karpas 422) exhibiting both t (14;18) and t(4;11) chromosomal translocations

1990 • 92 citations

Enhanced detection of the t(14;18) translocation in malignant lymphoma using pulsed-field gel electrophoresis

1991 • 71 citations

Regulation of bcl-2 gene expression in lymphoid cell lines containing normal #18 or t(14;18) chromosomes.

1989 • 39 citations

The nature of the hodgkin cell

1988 • 22 citations