Interactions Between Stroma and Epithelium in Breast Cancer

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

The insulin signaling system.

1994 • 1,733 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

DNA methylation and genomic imprinting

1994 • 349 citations

Expression of extracellular matrix components is regulated by substratum.

1990 • 345 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue.

1993 • 320 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.

1994 • 276 citations

Extracellular matrix promotes mammary epithelial growth and differentiation in vitro.

1982 • 262 citations

Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

1997 • 258 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

1996 • 243 citations

The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells

1996 • 223 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

M6P/IGF2 receptor: a candidate breast tumor suppressor gene.

1996 • 205 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor

1993 • 185 citations

PARENTAL IMPRINTING AND HUMAN DISEASE

1996 • 170 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion.

1989 • 158 citations

Stimulatory effects of insulin and insulin-like growth factor I on migration and tube formation by vascular endothelial cells

1992 • 153 citations

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1989 • 151 citations

The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells.

1992 • 137 citations

Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer.

1990 • 136 citations

Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function.

1995 • 134 citations

Identical allelic loss on chromosome 11q13 in microdissected in situ and invasive human breast cancer.

1995 • 128 citations

Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness

1996 • 124 citations

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.

1992 • 120 citations

Tamoxifen reduces serum insulin-like growth factor I (IGF-I)

1992 • 115 citations

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

1996 • 110 citations

Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme

1979 • 106 citations

Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

1993 • 97 citations

The insulin-like growth factor II/mannose 6-phosphate receptor is required for proliferin-induced angiogenesis.

1996 • 96 citations

Assessment of Differential Cytokine Effects on Angiogenesis Using an in Vivo Model of Cutaneous Wound Repair

1995 • 92 citations

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

1988 • 82 citations

Angiogenic and inflammatory responses following skeletal muscle injury are altered by immune neutralization of endogenous basic fibroblast growth factor, insulin-like growth factor-1 and transforming growth factor-β1

1996 • 79 citations

Abnormal properties of skin fibroblasts from patients with breast cancer

1984 • 75 citations

Insulin-like growth factor I stimulates proliferation, migration, and plasminogen activator release by human retinal pigment epithelial cells

1990 • 74 citations

Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cells

1995 • 72 citations

FIBROBLASTS FROM PATIENTS WITH BREAST CANCER SHOW ABNORMAL MIGRATORY BEHAVIOUR IN VITRO

1984 • 70 citations

Occurrence of a fetal fibroblast phenotype in familial breast cancer

1986 • 69 citations

IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study

1996 • 62 citations

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.

1996 • 61 citations

Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.

1997 • 61 citations

Capacity of Mammary Fat Pads of Adult C3H/HeMs Mice To Interact Morphogenetically With Fetal Mammary Epithelium2

1979 • 61 citations

Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells

1994 • 60 citations

FIBROBLASTS FROM RELATIVES OF PATIENTS WITH HEREDITARY BREAST CANCER SHOW FETAL-LIKE BEHAVIOUR IN VITRO

1987 • 60 citations

A Novel Human Insulin-Like Growth Factor I Messenger RNA is Expressed in Normal and Tumor Cells

1990 • 59 citations

Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources

1996 • 58 citations

Relaxation of Imprinting of Human Insulin-like Growth Factor II Gene,IGF2,in Sporadic Breast Carcinomas

1997 • 56 citations

Regulation of functional cytodifferentiation and histogenesis in mammary epithelial cells: role of the extracellular matrix.

1989 • 55 citations

Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions.

1994 • 51 citations

Phenotypic heterogeneity in breast fibroblasts: Functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma

1994 • 50 citations

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression

1992 • 48 citations

Fibroblast‐mediated differentiation in human breast carcinoma cells (MCF‐7) grown as nodules IN VITRO

1994 • 45 citations

Reversal of loss of imprinting in tumor cells by 5-aza-2'-deoxycytidine.

1997 • 39 citations

Expression of insulin-like growth factor I (IGF-I) in female breast cancer as related to established prognostic factors and long-term prognosis

1995 • 39 citations

Fibroblast stimulation of breast cancer cell growth in a serum-free system

1993 • 31 citations

The insulin-like growth factor II/mannose 6-phosphate receptor is required for proliferin-induced angiogenesis

1996 • 31 citations

Altered specificity of IGF2 promoter imprinting during fetal development and onset of Wilms tumour.

1995 • 30 citations

Insulin-like growth factor II modulates the routing of cathepsin D in MCF-7 breast cancer cells.

1996 • 30 citations

Tissue-Type Plasminogen Activator in Breast Cancer: Relationship With Estradiol and Progesterone Receptors

1986 • 30 citations

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor

1996 • 29 citations

Expression of insulin-like growth factor II in female breast cancer as related to established prognostic factors and long-term prognosis.

1995 • 29 citations

Hormonal modulation of plasminogen activator: an approach to prediction of human breast tumor responsiveness.

1987 • 27 citations

Does the Overexpression of Pro‐Insulin‐Like Growth Factor‐II in Transfected Human Embryonic Kidney Fibroblasts Increase the Secretion of Lysosomal Enzymes?

1995 • 19 citations

Coexpression of Stromelysin-3 and Insulin-Like Growth Factor II in Tumors of Ectodermal, Mesodermal, and Endodermal Origin: Indicator of a Fetal Cell Phenotype¹

1997 • 13 citations

Insulin-like growth factor II modulates the routing of cathepsin D in MCF-7 breast cancer cells

1996 • 10 citations

Coexpression of Stromelysin-3 and Insulin-Like Growth Factor II in Tumors of Ectodermal, Mesodermal, and Endodermal Origin: Indicator of a Fetal Cell Phenotype

1997 • 7 citations

Deleted Work

1955 • 0 citations