Recombinant human phenylalanine hydroxylase is a substrate for the ubiquitin-conjugating enzyme system

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

1980 • 530 citations

Ubiquitination

1991 • 430 citations

The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates.

1985 • 383 citations

Complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells

1975 • 350 citations

Proteasomes: protein degradation machines of the cell

1994 • 320 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Molecular Basis of Phenotypic Heterogeneity in Phenylketonuria

1991 • 239 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme

1995 • 184 citations

Stimulation of ATP-dependent proteolysis requires ubiquitin with the COOH-terminal sequence Arg-Gly-Gly.

1981 • 150 citations

The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes.

1988 • 133 citations

Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system

1987 • 132 citations

Molecular Characterization of the "26S" Proteasome Complex from Rat Liver

1993 • 131 citations

The Phenylalanine Hydroxylating System

1993 • 125 citations

Multiple Forms of Cytochrome c in the Rat

1968 • 116 citations

Identification of a Novel Family of Ubiquitin-conjugating Enzymes with Distinct Amino-terminal Extensions

1996 • 91 citations

Purification and Characterization of the 26S Proteasome Complex Catalyzing ATP-Dependent Breakdown of Ubiquitin-Ligated Prot from Rat Liver1

1993 • 85 citations

The inactivation of ubiquitin accounts for the inability to demonstrate ATP, ubiquitin-dependent proteolysis in liver extracts.

1985 • 77 citations

Proteasomes of the yeastS. cerevisiae: genes, structure and functions

1995 • 73 citations

Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E217kB) highly expressed in rat testis

1995 • 69 citations

Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease

1996 • 60 citations

PKU mutation G46S is associated with increased aggregation and degradation of the phenylalanine hydroxylase enzyme

1996 • 52 citations

Two apparent molecular weight forms of human and monkey phenylalanine hydroxylase are due to phosphorylation.

1984 • 42 citations

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria

1979 • 42 citations

Mouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase

1990 • 36 citations

Use of two‐dimensional gel electrophoresis and autoradiography as a tool in cell biology: The example of the thyroid and the liver

1990 • 25 citations

The mechanism of the irreversible inhibition ofrat liver phenylalanine hydroxylase due to treatment with p-chlorophenylalanine. The lack of effect on turnover of phenylalanine hydroxylase.

1979 • 24 citations

Measurement of phenylalanine hydroxylase turnover in cultured hepatoma cells.

1979 • 22 citations

Purification and characterization of ubiquitin from mammalian testis

1984 • 16 citations

Immunocytochemical identification of phenylalanine hydroxylase and albumin in cultured hepatoma cells and isolated rat hepatocytes.

1981 • 12 citations

Molecular cloning of cDNAs for two Xenopus proteasome subunits and their expression in adult tissues

1993 • 10 citations

Control of phenylalanine and tyrosine metabolism by phosphorylation mechanisms

1986 • 10 citations