Cytochrome P450 and biological hydroxylation reactions

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Porphyrins and metalloporphyrins

1976 • 1,942 citations

Porphyrins and Metalloporphyrins

1978 • 1,741 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of Liver

1962 • 909 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

ASCORBIC ACID IN AROMATIC HYDROXYLATION

1954 • 679 citations

Pigments of rat liver microsomes

1958 • 634 citations

Biological Reactive Intermediates

1977 • 597 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

Microsomes and drug oxidation

1969 • 451 citations

A Soluble Cytochrome P-450 Functional in Methylene Hydroxylation

1968 • 438 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase

1966 • 379 citations

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states.

1978 • 346 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

MECHANISM OF THE PYROCATECHASE REACTION

1955 • 337 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

OXYGEN TRANSFER AND ELECTRON TRANSPORT BY THE PHENOLASE COMPLEX¹

1955 • 308 citations

Interaction of Peroxidases with Aromatic Peracids and Alkyl Peroxides

1972 • 282 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

HYDROXYLATION OF STEROIDS AT CARBON 21

1957 • 272 citations

Enzymatic hydroxylation of aromatic compounds

1956 • 271 citations

Camphor binding by Pseudomonas putida cytochrome P-450

1971 • 262 citations

A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.

1976 • 261 citations

ALTERATIONS OF ADRENAL STEROID PATTERNS IN MAN RESULTING FROM TREATMENT WITH A CHEMICAL INHIBITOR OF 11 βHYDROXYLATION

1958 • 244 citations

Temperature dependence of cytochrome P-450 reduction. A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction.

1976 • 241 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1969 • 227 citations

The Purification And Properties Of Microsomal Cytochrome Reductase

1957 • 218 citations

Axial ligation modes in iron(III) porphyrins. Models for the oxidized reaction states of cytochrome P-450 enzymes and the molecular structure of iron(III) protoporphyrin IX dimethyl ester p-nitrobenzenethiolate

1976 • 199 citations

On the inhibitory action of mersalyl on microsomal drug oxidation: A rigid organization of the electron transport chain

1971 • 188 citations

Biological hydroxylation mechanisms

1973 • 186 citations

Interaction of Methylenedioxyphenyl (1,3-Benzodioxole) Compounds with Enzymes and Their Effects on Mammals

1975 • 183 citations

Origin of the anomalous Soret spectra of carboxycytochrome P-450

1976 • 180 citations

Binding of¹⁴C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl₃by Reduced Liver Microsomes

1973 • 177 citations

Cytochrome P450 as an oxene transferase

1976 • 176 citations

Cytochrome P-450cam

1974 • 161 citations

Oxygenated cytochrome P-450 and its possible role in enzymic hydroxylation

1971 • 160 citations

On the Mechanism of Action of the Adrenocorticotrophic Hormone

1970 • 158 citations

Isolation of chick renal mitochondrial ferredoxin active in the 25-hydroxyvitamin D3-1alpha-hydroxylase system.

1976 • 156 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

The role of mixed function oxidases in kaurene metabolism in Echinocystis macrocarpa greene endosperm

1969 • 148 citations

Mixed Function Oxidation

1965 • 146 citations

Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra

1969 • 141 citations

On the sulfate ester of N-hydroxy-N-2-fluorenylacetamide as a key ultimate hepatocarcinogen in the rat.

1972 • 138 citations

Enzymatic Hydroxylations with Molecular Oxygen

1972 • 138 citations

A Model Compound Study of the CO-Adduct of Cytochrome P-450

1974 • 136 citations

Model for the carbonyl adduct of ferrous cytochrome P 450

1975 • 134 citations

Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.

1976 • 133 citations

On the structure of the iron-sulfur complex in the two-iron ferredoxins

1971 • 132 citations

The Role of NADH in Uncoupled Microsomal Monoxygenations

1974 • 131 citations

Mössbauer studies of cytochrome P-450_cam

1973 • 127 citations

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

1977 • 126 citations

Hydroxylation of Aliphatic Compounds by Liver Microsomes, I. The Distribution Pattern of Isomeric Alcohols

1970 • 125 citations

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450

1976 • 124 citations

Studies on the Kinetics of Cytochrome P-450 Reduction in Rat Liver Microsomes

1970 • 123 citations

Fatty acid and hydrocarbon hydroxylation in yeast: Role of cytochrome P-450 in

1971 • 123 citations

The P-450 Nature of the Carbon Monoxide Complex of Ferrous Chloroperoxidase

1973 • 121 citations

Imidazole, the ligand trans to mercaptide in ferric cytochrome P-450. An EPR study of proteins and model compounds.

1977 • 120 citations

The Amino Acid Sequence of Bovine Adrenodoxin

1973 • 119 citations

Biochemie des Sauerstoffs

1968 • 118 citations

Microsomal electron transport reactions

1971 • 114 citations

Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea

1973 • 110 citations

The reduction of polyhalogenated methanes by liver microsomal cytochrome P450.

1977 • 104 citations

A Hemochromogen Component of Liver Microsomes

1952 • 103 citations

On the Hydroxylation of Cyclohexane in Rat Liver Microsomes

1969 • 101 citations

Studies on Tyrosine Hydroxylase from Bovine Adrenal Medulla

1968 • 100 citations

Uncoupling of Monooxygenation and Electron Transport by Flurocarbons in Liver Microsomes

1971 • 99 citations

Evidence for an α-ecdysone cytochrome P-450 mixed function oxidase in insect fat body mitochondria

1977 • 99 citations

Cytochrome P-450 as a microsomal peroxidase in steroid hydroperoxide reduction

1972 • 98 citations

Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: Evidence for the presence of cytochrome P-450

1976 • 97 citations

Metabolism and mechanism of action of oestrogens XII. Structure and mechanism of formation of water-soluble and protein-bound metabolites of oestrone in rat-liver microsomes in vitro and in vivo

1969 • 94 citations

3,4-Dihydroxyphenylethylamine β-Hydroxylase: a Copper Protein

1965 • 93 citations

Biochemical aspects of iron-sulfur linkage in non-heme iron protein, with special reference to “Adrenodoxin”

2008 • 92 citations

Membrane effects on drug monoxygenation activity in hepatic microsomes

1976 • 90 citations

Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver

1978 • 88 citations

An Electron Spin Resonance Study of Microsomal Fe

1967 • 88 citations

On the Mechanism of Action of an Ascorbic Acid-dependent Nonenzymatic Hydroxylating System

1960 • 87 citations

The mechanism of halothane binding to microsomal cytochrome P450

1974 • 86 citations

ENZYMATIC SYNTHESIS OF 17-HYDROXYCORTICOSTERONE

1951 • 86 citations

Nitrosoalkanes as Fe(II) Ligands in the 455-nm-Absorbing Cytochrome P-450 Complexes Formed from Nitroalkanes in Reducing Conditions

1977 • 86 citations

Ferric porphyrin thiolates. Possible relation to cytochrome P-450 enzymes and the structure of (p-nitrobenzenethiolato)iron(III) protoporphyrin IX dimethylester

1975 • 82 citations

Multiplicity of cytochrome P-450 hemoproteins in rat liver microsomes. Preparation and specificity of an antibody to the hemoprotein induced by phenobarbital.

1975 • 81 citations

The monooxygenation of n-heptane by rat liver microsomes

1972 • 80 citations

Formation and binding of carbanions by cytochrome P-450 of liver microsomes.

1973 • 75 citations

Isotope effects in O- and N-demethylations mediated by rat liver microsomes: An application of direct insertion electron impact mass spectrometry

1974 • 73 citations

Uncoupling of oxygen activation from hydroxylation in a bacterial salicylate hydroxylase

1970 • 72 citations

An Electron Paramagnetic Resonance Study of 3,4-Dihydroxyphenylethylamine β-Hydroxylase

1966 • 69 citations

Metabolism of polycyclic hydrocarbons by a highly active aryl hydrocarbon hydroxylase system in the liver of a trout species

1975 • 65 citations

A possible role of cytochrome P-450 in hydroxylation of progesterone by Rhizopus nigricans

1977 • 65 citations

Hydroxylation of Aliphatic Compounds by Liver Microsomes

1971 • 62 citations

Demonstration of a cytochrome P-450-dependent steroid 15β-hydroxylase in Bacillus megaterium

1975 • 59 citations

Chloroperoxidase. P-450 type absorption in the absence of sulfhydryl groups

1975 • 58 citations

The Mechanism of the Oxidation of Some Aromatic Amines by Peroxyacetic Acid

1962 • 58 citations

Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.

1973 • 56 citations

Nitrosoalkanes as Fe(II) Ligands in the Hemoglobin and Myoglobin Complexes Formed from Nitroalkanes in Reducing Conditions

1977 • 50 citations

Eigenschaften einer p-Anisat-O-Demethylase im zellfreien Extrakt von Pseudomonas species

1970 • 48 citations

The rate of pentobarbital and acetanilide metabolism by liver microsomes: a function of lipid peroxidation and degradation of cytochrome P-450 heme.

1973 • 46 citations

Zum wirkungsmechanismus der ascorbinsäure I. Isolierung einer ascorbinsäureabhängigen DPNH-oxydase aus nebennierenmikrosomen

1958 • 46 citations

Participation du cytochrome P₄₅₀ dans l'oxydation des alcanes chez Candida tropicalis

1971 • 45 citations

Complexes of Metabolites of Amphetamines with Hepatic Cytochrome P-450

1974 • 44 citations

Relationship between NADH and NADPH oxidation during drug metabolism.

1973 • 44 citations

Binding of thiols to microsomal cytochrome P-450

1976 • 43 citations

The Mixed Function Oxygenation of 4-Halogenoacetanilides in Rat Liver Microsomes and Model Systems

1968 • 42 citations

Isolation from bovine liver mitochondria of a soluble ferredoxin active in a reconstituted steroid hydroxylation reaction

1977 • 41 citations

Über den Verlauf der Oxydationsvorgänge

1922 • 40 citations

Uncoupling of oxygen activation from hydroxylation in the steroid C-21 hydroxylase of bovine adrenocortical microsomes

1971 • 40 citations

The solubilization and separation of two forms of microsomal cytochrome P-450 from the house fly, Musca domestica L

1975 • 34 citations

Isolation of rat liver mitochondrial ferredoxin and its reductase active in the 5beta-cholestane-3alpha, 7alpha, 12alpha-triol 26-hydroxylase

1978 • 32 citations

Oxygen Activation by the Iron(II)-2-Mercaptobenzoic Acid Complex. A Model for Microsomal Mixed Function Oxygenases

1969 • 31 citations

519. Chemical actions of ionising radiations on aqueous solutions. Part V. Hydroxylation of nitrobenzene by free radicals produced by X-rays

1950 • 31 citations

Pseudomonas putida cytochrome P-450. Binding of a spin-labeled analog of the inhibitor metyrapone

1974 • 28 citations

1031. Hydroxylation. Part II. Electrophilic hydroxylations with trifluoroperoxyacetic acid

1964 • 28 citations

Cytochrome P-450 in 7α-hydroxylation of taurodeoxycholic acid

1973 • 24 citations

The photochemical action spectrum of the carbon monoxide inhibited hydroxylation of cyclohexane by rat liver microsomes

1969 • 24 citations

The Accumulation of Mestranol and Ethynyloestradiol Metabolites in the Organism

1972 • 22 citations

STIMULATORY EFFECTS OF POLYCHLORINATED BIPHENYLS (PCB) ON CYTOCHROMES P-450 AND P-448 MEDIATED MICROSOMAL OXIDATIONS

1977 • 21 citations

REDOX AND LIGAND DYNAMICS IN P450cam-PUTIDAREDOXIN COMPLEXES

1977 • 20 citations

ACTIVE OXYGEN—FACT OR FANCY

1977 • 19 citations

THE MECHANISM OF CYTOCHROME P450 ACTION

1977 • 19 citations

Über die Existenz des Perhydroxylradikals in wäßrigen Lösungen und seine Bedeutung bei Oxydationsreaktionen

1964 • 17 citations

Zum Mechanismus der Hydroxylierungen mit molekularem Sauerstoff und Zinn(II)-Komplexen

1969 • 17 citations

Zum Reaktionsmechanismus der nichtenzymatischen Hydroxylierung.

1964 • 16 citations

Chick kidney microsomal cytochrome P-450 involvement in the metabolism of 25-hydroxyvitamin D3

1977 • 14 citations

Incremental changes in deer mouse (Peromyscus maniculatus) core temperatures during behavioral challenges

1978 • 13 citations

Aktivierung von Sauerstoff in Modellsystemen

1968 • 11 citations

PURIFICATION OF MEMBRANE–BOUND OXYGENASES: ISOLATION OF TWO ELECTROPHORETICALLY HOMOGENEOUS FORMS OF LIVER MICROSOMAL CYTOCHROME P-450

1977 • 8 citations

INTERACTIONS BETWEEN CYTOCHROME P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN THE MICROSOMAL MEMBRANE

1977 • 5 citations

Über den Verlauf der Oxydationsvorgänge. Von Prof. Dr. H. Wieland. Ferd. Enke Verlag, Stuttgart 1933. Preis geh. RM. 7.80

1935 • 5 citations

Cytochrome P-450 in steroid biogenesis

1969 • 4 citations

Chapter 30. Cytochrome P-450 Monoxygenases and Drug Metabolism

1974 • 4 citations