Chapter 30. Cytochrome P-450 Monoxygenases and Drug Metabolism

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

ASCORBIC ACID IN AROMATIC HYDROXYLATION

1954 • 679 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Hydroxylation-Induced Migration: The NIH Shift

1967 • 519 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. V

1970 • 428 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1972 • 350 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

The Biochemistry of Foreign Compounds

1968 • 302 citations

The biochemistry of foreign compounds

1968 • 263 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

1968 • 222 citations

Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

1969 • 218 citations

ASCORBIC ACID IN AROMATIC HYDROXYLATION

1954 • 215 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates

1968 • 215 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1973 • 208 citations

THE ENZYMATIC DEAMINATION OF AMPHETAMINE (BENZEDRINE)

1955 • 204 citations

Effect of Superoxide Generation and Dismutation on Hydroxylation Reactions Catalyzed by Liver Microsomal Cytochrome P-450

1971 • 189 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Oxygenated cytochrome P-450 and its possible role in enzymic hydroxylation

1971 • 160 citations

Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH

1968 • 127 citations

Studies on the Kinetics of Cytochrome P-450 Reduction in Rat Liver Microsomes

1970 • 123 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates

1971 • 118 citations

Kinetics of drug metabolism by hepatic microsomes

1964 • 117 citations

Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.

1969 • 111 citations

On the Hydroxylation of Cyclohexane in Rat Liver Microsomes

1969 • 101 citations

Mechanism of p-nitrobenzoate reduction in liver: the possible role oc cytochrome P-450 in liver microsomes.

1968 • 94 citations

Properties of cytochrome P-450 as affected by environmental factors: Qualitative changes due to administration of polycyclic hydrocarbons

1971 • 90 citations

Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.

1968 • 87 citations

A Comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes

1969 • 80 citations

Alteration of the microsomal hemoprotein by 3-methylcholanthrene: effects of ethionine and actinomycin D.

1968 • 77 citations

Electron Paramagnetic Resonance Study of the High- and Low-Spin Forms of Cytochrome P-450 in Liver and in Liver Microsomes from a Methylcholanthrene-Treated Rabbit

1970 • 76 citations

Foreign Compound Metabolism in Mammals

1979 • 73 citations

Crystalline cytochrome P-450cam

1970 • 73 citations

Rearrangement of [1-2H]- and [2-2H]naphthalene 1,2-oxides to 1-naphthol. Mechanism of the NIH shift

1972 • 70 citations

The mechanism of oxidation of amphetamine enantiomorphs by liver microsomal preparations from different species

1972 • 66 citations

A reconstituted microsomal enzyme system that converts naphthalene to trans-1,2-dihydroxy-1,2-dihydronaphthalene via naphthalene-1,2-oxide: Presence of epoxide hydrase in cytochrome P-450 and P-448 fractions

1972 • 64 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.

1972 • 63 citations

Enzymatic oxidation of pentobarbital and thiopental.

1957 • 61 citations

Phenylacetone oxime—An intermediate in the oxidative deamination of amphetamine

1971 • 61 citations

Effects of Steroid Hormones on Drug-metabolizing Enzyme Systems in Liver Microsomes*

1968 • 60 citations

The microsomal oxygenation of ethyl benzene: Isotopic, stereochemical, and induction studies

1969 • 58 citations

A Hydroxylation of Anisole by Hydrogen Peroxide Requiring Catalytic Amounts of Ferric Ion and Catechol

1963 • 56 citations

EPR measurements of substrate interaction with cytochrome P-450

1966 • 55 citations

Migration of substituents during hydroxylation of aromatic substrates (NIH shift). Oxidations with peroxytrifluoroacetic acid

1971 • 53 citations

S-methylation, oxidation, hydroxylation and conjugation of thiophenol in the rat

1969 • 52 citations

The mechanism of the oxidation of d-amphetamine by rabbit liver oxygenase. Oxygen-18 studies

1971 • 52 citations

Hepatic microsomal N-dealkylation reaction. Molecular oxygen as the source of the oxygen atom

1969 • 52 citations

Intramolecular migration of tritium and deuterium during nonenzymic aromatic hydroxylation

1967 • 51 citations

Photolysis of pyridine-N-oxide: an oxygen atom transfer model for enzymatic oxygenation, arene oxide formation, and the NIH shift

1970 • 51 citations

Metabolic studies of tolbutamide in the rat

1967 • 50 citations

Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagents

1971 • 49 citations

Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.

1969 • 48 citations

The migration of deuterium during aryl hydroxylation

1969 • 44 citations

Evidence for an inhibitory product · cytochrome P-450 complex generated during benzphetamine metabolism by liver microsomes

1973 • 43 citations

ETHYL(3-HYDROXYISOAMYL)BARBITURIC ACID AS THE PRINCIPAL METABOLITE OF AMYTAL

1952 • 43 citations

The Mixed Function Oxygenation of 4-Halogenoacetanilides in Rat Liver Microsomes and Model Systems

1968 • 42 citations

Effect of deuteration of the OCH3 group on the enzymic demethylation of o-nitroanisole☆

1967 • 40 citations

Side-chain degradation and ring hydroxylation of pehnothiazine tranquilizers.

1965 • 39 citations

Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.

1969 • 39 citations

Microsomal hydroxylation of ethylbenzene. Stereospecificity and the effect of phenobarbital induction

1966 • 39 citations

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates

1972 • 37 citations

The Enzymatic N-Hydroxylation of an Imine

1971 • 37 citations

Oxidative N -Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man

1971 • 36 citations

The rate-limiting step in aminopyrine demethylase of rat liver microsomes

1970 • 36 citations

Deuterium migration during the acid-catalyzed dehydration of 6-deuterio-5,6-dihydroxy-3-chloro-1,3-cyclohexadi-ene, a nonenzymic model for the NIH shift

1967 • 35 citations

Properties of partially purified liver microsomal cytochrome P‐450: Acceptance of two electrons during anaerobic titration

1974 • 32 citations

Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone

1973 • 28 citations

Studies on the demethylation,hydroxylation and N-oxidation of imipramine in rat liver

1970 • 28 citations

On the mechanism of oxidative cleavage of aryl-alkyl ethers by liver microsomes.

1965 • 27 citations

Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene

1971 • 26 citations

Piperonyl Butoxide Metabolism by Cytochrome P-450: Factors Affecting the Formation and Disappearance of the Metabolite-Cytochrome P-450 Complex

1972 • 24 citations

The importance of cytochrome P-450 and P-448 in determining the specificity of the reconstituted liver microsomal hydroxylation system

1971 • 16 citations

The Metabolism by Man of an Anticonvulsant Oxadiazole. An unusual Metabolic Route for Tertiary Amides

1971 • 13 citations

Sequential Solubilization of Microsomal Mixed Function Oxidases

1973 • 11 citations

Induction of drug metabolism. IV. Relative abilities of polycyclic hydrocarbons to increase levels of microsomal 3-methyl-4-methylaminoazobenzene N-demethylase activity and cytochrome P1-450.

1970 • 11 citations

Free-radical hydroxylation of steroids

1972 • 10 citations

Microsomal 3-hydroxylation of 1,4-benzodiazepines

1971 • 9 citations

The oxidation of N-p-benzotrideuteridesulfonyl N'-n-butylurea (tolbutamide-D3) by man

1961 • 8 citations

Induction of drug metabolism. VII. Differences in P-420 hemoproteins from untreated and 3-methylcholanthrene-treated rats.

1973 • 3 citations