PURIFICATION OF MEMBRANE–BOUND OXYGENASES: ISOLATION OF TWO ELECTROPHORETICALLY HOMOGENEOUS FORMS OF LIVER MICROSOMAL CYTOCHROME P-450

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

[92] The preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver

1967 • 558 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

1974 • 518 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

1975 • 456 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.

1957 • 399 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1972 • 350 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Mechanisms of Oxygen Metabolism

1957 • 312 citations

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits

1974 • 304 citations

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 270 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 263 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

The Structural Basis of Membrane Function

1976 • 253 citations

Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

1972 • 247 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES

1965 • 218 citations

Autooxidation and hydroxylation reactions of oxygenated cytochrome P-450cam.

1976 • 215 citations

Evidence for superoxide generation by NADPH-cytochrome C reductase of rat liver microsomes

1972 • 193 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Highly purified cytochrome P-448 and P-450 from rat liver microsomes

1975 • 189 citations

Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver

1975 • 186 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

Carcinogens, Enzyme Induction, and Gene Action

1967 • 172 citations

Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes

1974 • 171 citations

Sodium periodate, sodium chlorite, organic hydroperoxides, and H2O2 as hydroxylating agents in steroid hydroxylation reactions catalyzed by partially purified cytochrome P-450

1975 • 168 citations

Cytochrome P-450 purified to apparent homogeneity from phenobarbital-induced rabbit liver microsomes: Catalytic activity and other properties

1974 • 164 citations

Oxygenated cytochrome P-450 and its possible role in enzymic hydroxylation

1971 • 160 citations

Flavins and flavoproteins

1977 • 144 citations

Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra

1969 • 141 citations

Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes.

1970 • 138 citations

Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits

1976 • 134 citations

The Role of NADH in Uncoupled Microsomal Monoxygenations

1974 • 131 citations

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450

1976 • 124 citations

Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential.

1975 • 120 citations

Kinetics of drug metabolism by hepatic microsomes

1964 • 117 citations

Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450

1975 • 107 citations

Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction

1973 • 90 citations

Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.

1968 • 87 citations

Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits.

1975 • 83 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Induction

1973 • 69 citations

Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver.

1975 • 69 citations

Hydroperoxide-supported cytochrome P-450-linked fatty acid hydroxylation in liver microsomes

1975 • 65 citations

Effects of Steroid Hormones on Drug-metabolizing Enzyme Systems in Liver Microsomes*

1968 • 60 citations

Sodium periodate, sodium chlorite, and organic hydroperoxides as hydroxylating agents in hepatic microsomal steroid hydroxylation reactions catalyzed by cytochrome P‐450

1975 • 59 citations

On the mechanism of hydroxylation reactions catalyzed by cytochrome P-450.

1973 • 54 citations

P-450cam hydroxylase: substrate-effector and electron-transport reactions

1971 • 51 citations

Ligand interaction with hemoprotein P-450. 3. The use of n-octylamine and ethyl isocyanide difference spectroscopy in the quantitative determination of high- and low-spin P-450.

1970 • 45 citations

Relationship between NADH and NADPH oxidation during drug metabolism.

1973 • 44 citations

Properties of partially purified liver microsomal cytochrome P‐450: Acceptance of two electrons during anaerobic titration

1974 • 32 citations

On the solubilization of NADPH-cytochrome c reductase from rat liver microsomes with crude pancreatic lipase

1972 • 27 citations

Hydroperoxide‐supported cytochrome P‐450‐linked fatty acid hydroxylation in liver microsomes

1975 • 25 citations

An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate.

1972 • 11 citations

Stoichiometry of drug metabolism in maturing male rats

1974 • 5 citations