Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

1987 • 765 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

The fluorometric analysis of ultramicro quantities of hydrogen peroxide

1965 • 576 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B₄

1989 • 244 citations

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.

1988 • 229 citations

The role of the phagocyte in host-parasite interactions

1968 • 198 citations

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils

1991 • 195 citations

Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

1990 • 187 citations

Stimulation of free radical generation in human leukocytes by various agents including tumor necrosis factor is a calmodulin dependent process

1990 • 117 citations

Oxidative Metabolism in the Alveolar Macrophage: Analysis by Flow Cytometry

1990 • 105 citations

Calmodulin antagonists modulate rabbit neutrophil degranulation, aggregation and stimulated oxygen consumption

1981 • 56 citations

Phorbol Myristate Acetate Induced Oxidation of 2′,7′-Dichlorofluorescin by Neutrophils From Patients With Chronic Granulomatous Disease

1988 • 28 citations

Evidence for generation of a large amount of nitric oxide-like vascular smooth muscle relaxant by cholesterol-rich neutrophils

1990 • 13 citations