A New Look at Crohn's Disease

Antimicrobial peptides of multicellular organisms

2002 • 7,993 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Inflammatory Bowel Disease

2002 • 3,038 citations

Defensins: antimicrobial peptides of innate immunity

2003 • 2,903 citations

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

2005 • 1,741 citations

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

2004 • 1,451 citations

Mucosal flora in inflammatory bowel disease

2002 • 1,344 citations

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

2001 • 1,295 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

2000 • 1,002 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

Reduced Paneth cell α-defensins in ileal Crohn's disease

2005 • 943 citations

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

2002 • 885 citations

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

1998 • 832 citations

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal -defensin expression

2004 • 795 citations

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

2003 • 752 citations

Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial

2005 • 719 citations

Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer 1 1The authors thank Professor T. K. Korhonen (Division of General Microbiology, University of Helsinki, Finland), who kindly donated Escherichia coli IH11165; Professor J.-F. Colombel (Laboratoire de Recherche sur les Maladies Inflammatoire de l’Intestine, Centre Hospitalier Universitaire, Lille, France) and Professor A. Darfeuille-Michaud (Faculte de Pharmacie, Clermont-Ferrand, France), who kindly donated …

2004 • 685 citations

Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.

1999 • 602 citations

Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

1996 • 571 citations

Crohn’s disease and the NOD2 gene: a role for paneth cells

2003 • 528 citations

Paneth cells of the human small intestine express an antimicrobial peptide gene

1992 • 525 citations

Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium

1999 • 496 citations

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium

2004 • 469 citations

Paneth cell trypsin is the processing enzyme for human defensin-5

2002 • 415 citations

β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells

2004 • 348 citations

Antibiotic peptides as mediators of innate immunity

1992 • 345 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Inducible and Constitutive β-Defensins Are Differentially Expressed in Crohn's Disease and Ulcerative Colitis

2003 • 293 citations

Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

1996 • 277 citations

Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease

2002 • 265 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis

2003 • 206 citations

Human β-defensin 2 but not β-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

2002 • 201 citations

By IL-1 Signaling, Monocyte-Derived Cells Dramatically Enhance the Epidermal Antimicrobial Response to Lipopolysaccharide

2003 • 180 citations

Mechanisms of Disease: defensins in gastrointestinal diseases

2005 • 164 citations

Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease

2004 • 155 citations

Crohn's disease

2003 • 149 citations

Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression

2003 • 135 citations

β-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis

2004 • 134 citations

Airway epithelia regulate expression of human β‐defensin 2 through toll‐like receptor 2

2003 • 95 citations

The Paneth cell and the innate immune response

2004 • 93 citations

Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status

2003 • 72 citations

Genotypes and phenotypes in Crohn's disease: do they help in clinical management?

2004 • 62 citations

Antimicrobial peptides in innate immunity of the human intestine

2003 • 57 citations

“For Whom the Bell Tolls!” - Innate Defense Mechanisms and Survival Strategies of the Intestinal Epithelium Against Lumenal Pathogens

2002 • 42 citations