Transfer of Secretory Proteins through the Membrane of the Endoplasmic Reticulum

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

Signal sequences

1985 • 2,179 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

Intracellular protein topogenesis

1980 • 1,378 citations

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

1975 • 1,175 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL

1969 • 1,134 citations

A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM

1955 • 949 citations

LIVER MICROSOMES

1956 • 919 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Compilation of published signal sequences

1984 • 784 citations

Disulphide bridges in globular proteins

1981 • 770 citations

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

1982 • 766 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1985 • 622 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Synchronised transmembrane insertion and glycosylation of a nascent membrane protein

1977 • 529 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS*

1980 • 461 citations

Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver

1963 • 439 citations

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 414 citations

Small RNA species of the HeLa cell: Metabolism and subcellular localization

1976 • 409 citations

The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

1979 • 408 citations

Secretion and Membrane Localization of Proteins inEscherichia Coli

1980 • 402 citations

Role of carbohydrates in protein secretion and turnover: Effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts

1978 • 391 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

STUDIES ON THE ENDOPLASMIC RETICULUM

1955 • 374 citations

Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein

1977 • 366 citations

Trans‐membrane Translocation of Proteins

1979 • 364 citations

Biosynthesis of Serum Proteins and Ferritin by Free and Attached Ribosomes of Rat Liver

1969 • 360 citations

RIBOSOME-MEMBRANE INTERACTION

1973 • 337 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope.

1983 • 307 citations

Preferential Synthesis of Ferritin and Albumin by Different Populations of Liver Polysomes

1969 • 301 citations

On the attachment of ribosomes to microsomal membranes

1966 • 301 citations

The Binding of Cytochrome b5 to Liver Microsomes

1972 • 286 citations

The mechanism of protein secretion across membranes

1980 • 285 citations

Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes

1978 • 281 citations

Synthesis and Transfer of Amylase in Pigeon Pancreatic Microsomes

1966 • 272 citations

Mutations in a new gene, secB, cause defective protein localization in Escherichia coli

1983 • 270 citations

Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli

1980 • 268 citations

A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

1978 • 266 citations

Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity.

1977 • 259 citations

Assembly of Proteins into Membranes

1980 • 255 citations

ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER

1974 • 252 citations

Vectorial discharge of peptides released by puromycin from attached ribosomes.

1966 • 247 citations

Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution

1982 • 246 citations

Density of newly synthesized plasma membrane proteins in intracellular membranes II. Biochemical studies.

1984 • 246 citations

Disassembly and reconstitution of signal recognition particle

1983 • 242 citations

Purification and characterization of leader (signal) peptidase from Escherichia coli.

1980 • 237 citations

Translocation of domains of nascent periplasmic proteins across the cytoplasmic membrane is independent of elongation

1983 • 234 citations

Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

1984 • 230 citations

The low molecular weight RNAs of Rous sarcoma virus

1970 • 223 citations

The Effect of Fatty Acids on the Binding of Tryptophan to Plasma Protein

1973 • 221 citations

Effects of two sec genes on protein assembly into the plasma membrane of Escherichia coli.

1985 • 217 citations

A defined mutation in the protein export gene within the spc ribosomal protein operon of Escherichia coli: isolation and characterization of a new temperature-sensitive secY mutant.

1984 • 216 citations

Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli.

1983 • 214 citations

Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an Alu sequence

1982 • 212 citations

An artificial anchor domain: hydrophobicity suffices to stop transfer

1985 • 206 citations

British Optical Astronomy

1972 • 204 citations

Lipid Linked Sugars in Glycoprotein Synthesis

1975 • 201 citations

Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin.

1977 • 199 citations

Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.

1979 • 199 citations

Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin

1978 • 195 citations

Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein

1980 • 195 citations

On the Hydrophobic Nature of Signal Sequences

1981 • 193 citations

Size Distribution of Membrane Proteins of Rat Liver and Their Relative Rates of Degradation

1971 • 192 citations

Transmembrane assembly of membrane and secretory glycoproteins

1981 • 188 citations

Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein

1978 • 187 citations

Distribution of Saccharide Residues on Membrane Fragments from a Myeloma-Cell Homogenate: Its Implications for Membrane Biogenesis

1972 • 185 citations

Impaired conversion of procollagen to collagen by fibroblasts and bone treated with tunicamycin, an inhibitor of protein glycosylation.

1977 • 183 citations

The isolation of homogeneous leader peptidase from a strain of Escherichia coli which overproduces the enzyme.

1982 • 179 citations

Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.

1985 • 179 citations

Assembly of the semliki forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro

1978 • 178 citations

Predicted secondary structures of amino‐terminal extension sequences of secreted proteins

1979 • 172 citations

Ribosomal-membrane interaction: In vitro binding of ribosomes to microsomal membranes

1974 • 170 citations

Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes.

1980 • 165 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

NH2-terminal hydrophobic region of influenza virus neuraminidase provides the signal function in translocation.

1984 • 156 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

Modern cell biology

1983 • 153 citations

Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region.

1978 • 153 citations

Importance of secondary structure in the signal sequence for protein secretion.

1983 • 152 citations

AN IMPROVED CELL FRACTIONATION PROCEDURE FOR THE PREPARATION OF RAT LIVER MEMBRANE-BOUND RIBOSOMES

1973 • 152 citations

Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes.

1984 • 149 citations

Formation of intermolecular disulfide bonds on nascent immunoglobulin polypeptides.

1979 • 147 citations

Bacteria mature preproinsulin to proinsulin.

1980 • 143 citations

A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems

1983 • 142 citations

Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites

1978 • 142 citations

In vitro SYNTHESIS OF DIFFERENT CATEGORIES OF SPECIFIC PROTEIN BY MEMBRANE-BOUND AND FREE RIBOSOMES

1969 • 141 citations

A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane.

1980 • 140 citations

Topology of signal recognition particle receptor in endoplasmic reticulum membrane

1985 • 140 citations

Purification and Properties of an Enzyme from Beef Liver Which Catalyzes Sulfhydryl-Disulfide Interchange in Proteins

1966 • 139 citations

Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum.

1980 • 137 citations

Mechanism of signal peptide cleavage in the biosynthesis of the major lipoprotein of the Escherichia coli outer membrane.

1982 • 133 citations

An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein.

1978 • 131 citations

In Vivo Function and Membrane Binding Properties Are Correlated for Escherichia coli lamB Signal Peptides

1985 • 130 citations

Escherichia coli mutants accumulating the precursor of a secreted protein in the cytoplasm

1979 • 129 citations

Localization of the enzyme system for glycosylation of proteins via the lipid-linked pathway in rough endoplasmic reticulum.

1977 • 129 citations

A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery

1982 • 126 citations

Conformational changes associated with proteolytic processing of presecretory proteins allow glutathione-catalyzed formation of native disulfide bonds.

1982 • 125 citations

The biosynthesis of rat serum albumin. In vivo studies on the formation of the disulfide bonds.

1982 • 124 citations

Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes.

1979 • 124 citations

Human genes and pseudogenes for the 7SL RNA component of signal recognition particle.

1984 • 122 citations

M13 procoat and a pre-immunoglobulin share processing specificity but use different membrane receptor mechanisms.

1983 • 122 citations

Diverse effects of mutations in the signal sequence on the secretion of β-lactamase in Salmonella typhimurium

1982 • 121 citations

Presecretory and cytoplasmic invertase polypeptides encoded by distinct mRNAs derived from the same structural gene differ by a signal sequence.

1982 • 120 citations

Protein synthesis by membrane-bound and free ribosomes of secretory and non-secretory tissues

1971 • 120 citations

Isolation of the Escherichia coli leader peptidase gene and effects of leader peptidase overproduction in vivo.

1981 • 119 citations

Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes.

1984 • 118 citations

A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.

1982 • 118 citations

Exploring the conformational roles of signal sequences: synthesis and conformational analysis of .lambda. receptor protein wild-type and mutant signal peptides

1984 • 117 citations

Detection and kinetic behavior of preproinsulin in pancreatic islets.

1978 • 116 citations

Glycosylation of ovalbumin nascent chains. The spatial relationship between translation and glycosylation.

1980 • 116 citations

Protein transfer across microsomal membranes reassembled from separated membrane components

1978 • 114 citations

The organization of the 7SL RNA in the signal recognition particle

1983 • 114 citations

Studies on the Biosynthesis of Microsomal Membrane Proteins

1982 • 114 citations

Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane.

1982 • 112 citations

Leader peptidase is found in both the inner and outer membranes of Escherichia coli.

1981 • 111 citations

Intragenic suppressor mutations that restore export of maltose binding protein with a truncated signal peptide

1984 • 111 citations

Glycosylation of a membrane protein is restricted to the growing polypeptide chain but is not necessary for insertion as a transmembrane protein

1978 • 110 citations

Conformational studies of the synthetic precursor-specific region of preproparathyroid hormone.

1980 • 109 citations

ELECTRON MICROSCOPE EXAMINATION OF SUBCELLULAR FRACTIONS

1971 • 109 citations

ISOLATION OF SMOOTH VESICLES AND FREE RIBOSOMES FROM RAT LIVER MICROSOMES

1962 • 103 citations

Mechanism of compartmentation of secretory proteins: transport of exocrine pancreatic proteins across the microsomal membrane

1980 • 99 citations

A prokaryotic membrane anchor sequence: carboxyl terminus of bacteriophage f1 gene III protein retains it in the membrane.

1982 • 94 citations

The low molecular weight RNAs of Rous sarcoma virus

1970 • 93 citations

Synthesis of rat liver microsomal cytochrome b5 by free ribosomes.

1980 • 93 citations

Transmembrane assembly of N-linked glycoproteins. Studies on the topology of saccharide synthesis.

1982 • 92 citations

The erythrocyte anion transport protein is cotranslationally inserted into microsomes

1982 • 92 citations

Role of disulfide interchange enzyme in immunoglobulin synthesis

1981 • 90 citations

Assembly in vitro of a spanning membrane protein of the endoplasmic reticulum: the E1 glycoprotein of coronavirus mouse hepatitis virus A59.

1984 • 90 citations

N-Linked glycoprotein assembly. Evidence that oligosaccharide attachment occurs within the lumen of the endoplasmic reticulum.

1980 • 90 citations

Prolipoprotein signal peptidase in Escherichia coli is distinct from the M13 procoat protein signal peptidase.

1982 • 89 citations

Nascent chicken ovalbumin contains the functional equivalent of a signal sequence.

1978 • 89 citations

Segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in Xenopus oocytes

1984 • 89 citations

Nucleotide sequence of 7 S RNA. Homology to Alu DNA and La 4.5 S RNA.

1982 • 88 citations

The signal sequence of ovalbumin is located near the NH2 terminus.

1982 • 88 citations

Membrane biogenesis. In vitro cleavage, core glycosylation, and integration into microsomal membranes of sindbis virus glycoproteins.

1979 • 85 citations

Effect of tunicamycin on the biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in the leukemia cell line K562.

1980 • 85 citations

Structure and evolution of the 7SL RNA component of the signal recognition particle.

1984 • 85 citations

Biosynthesis and processing of ribophorins in the endoplasmic reticulum.

1984 • 83 citations

Studies on the Transfer of Incomplete Polypeptide Chains across Rat Liver Microsomal Membranes in Vitro

1967 • 83 citations

A zinc metalloendopeptidase associated with dog pancreatic membranes.

1980 • 82 citations

Purification and characterization of a thiol:protein disulfide oxidoreductase from bovine liver.

1977 • 81 citations

Membrane insertion of alpha- and beta-subunits of Na+,K+-ATPase.

1985 • 81 citations

Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an integral glycoprotein of the endoplasmic reticulum.

1984 • 80 citations

Segregation of the polypeptide translocation apparatus to regions of the endoplasmic reticulum containing ribophorins and ribosomes. II. Rat liver microsomal subfractions contain equimolar amounts of ribophorins and ribosomes.

1984 • 80 citations

Assembly of Membrane-bound Polyribosomes

1971 • 78 citations

Spatial orientation of glycoproteins in membranes of rat liver rough microsomes. I. Localization of lectin-binding sites in microsomal membranes.

1978 • 78 citations

Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.

1983 • 77 citations

The secondary structure of the 7SL RNA in the signal recognition particle: functional implications

1985 • 77 citations

POST‐TRANSLATIONAL PROCESSING OF FULL‐LENGTH PRESECRETORY PROTEINS WITH CANINE PANCREATIC SIGNAL PEPTIDASE

1980 • 76 citations

Studies on Polysome‐Membrane Interactions in Mouse Myeloma Cells

1974 • 75 citations

Primary structure of the membranous segment of cytochrome b5.

1977 • 74 citations

Inhibition of preprotein processing in ascites tumor lysates by incorporation of a leucine analog

1980 • 74 citations

Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy

1977 • 74 citations

The latency of rat liver microsomal protein disulphide-isomerase

1985 • 74 citations

Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems.

1985 • 73 citations

Characterization of the ribosomal binding site in rat liver rough microsomes: Ribophorins I and II, two integral membrane proteins related to ribosome binding

1978 • 73 citations

Temporal relationship of translation and glycosylation of immunoglobulin heavy and light chains

1978 • 73 citations

Transmembrane biogenesis of the vesicular stomatitis virus glycoprotein.

1979 • 73 citations

Release of poly a(+) messenger RNA from rat liver rough microsomes upon disassembly of bound polysomes

1977 • 70 citations

The association in vitro of polyribosomes with ribonuclease-treated derivatives of hepatic rough endoplasmic reticulum. Characteristics of the membrane binding sites and factors influencing association

1971 • 69 citations

mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.

1982 • 68 citations

Glycosylation is not necessary for membrane insertion and cleavage of Semliki Forest virus membrane proteins

1978 • 67 citations

A mutation downstream from the signal peptidase cleavage site affects cleavage but not membrane insertion of phage coat protein.

1981 • 67 citations

Co-translational membrane integration of calcium pump protein without signal sequence cleavage

1981 • 67 citations

Hen oviduct signal peptidase is an integral membrane protein.

1983 • 65 citations

Characterization of molecules involved in protein translocation using a specific antibody.

1982 • 64 citations

Characterization of an endopeptidase involved in pre-protein processing.

1979 • 63 citations

Protease IV, a cytoplasmic membrane protein of Escherichia coli, has signal peptide peptidase activity.

1984 • 63 citations

Evidence for conformational differences between precursor and processed forms of thyroid-stimulating hormone beta subunit.

1979 • 63 citations

The Relationship between Ribosomes and the Endoplasmic Reticulum during Protein Synthesis

1965 • 62 citations

Translational and post-translational cleavage of M13 procoat protein: extracts of both the cytoplasmic and outer membranes of Escherichia coli contain leader peptidase activity.

1979 • 61 citations

The 7S RNA Common to Oncornaviruses and Normal Cells is Associated with Polyribosomes

1974 • 61 citations

Localization and biosynthesis of NADH-cytochrome b5 reductase, an integral membrane protein, in rat liver cells. I. Distribution of the enzyme activity in microsomes, mitochondria, and golgi complex.

1980 • 61 citations

A structural and functional analysis of the docking protein. Characterization of active domains by proteolysis and specific antibodies.

1985 • 61 citations

Molecular components of the signal sequence that function in the initiation of protein export.

1982 • 61 citations

Isolation and characterization of an Escherichia coli clone overproducing prolipoprotein signal peptidase.

1983 • 58 citations

Immunochemical analysis of rough and smooth microsomes from rat liver. Segregation of docking protein in rough membranes

1985 • 57 citations

Comparison of oligonucleotides produced by RNase T1 digestion of 7 S RNA from avian and murine oncornaviruses and from uninfected cells

1973 • 57 citations

In vitro synthesis of the Ca ²⁺ transport ATPase by ribosomes bound to sarcoplasmic reticulum membranes

1979 • 56 citations

Co‐translational modification of nascent immunoglobulin heavy and light chains

1979 • 55 citations

Erythrocyte membrane protein band 3: its biosynthesis and incorporation into membranes.

1981 • 55 citations

Design and synthesis of a consensus signal sequence that inhibits protein translocation into rough microsomal vesicles

1984 • 54 citations

Spatial orientation of glycoproteins in membranes of rat liver rough microsomes. II. Transmembrane disposition and characterization of glycoproteins.

1978 • 52 citations

Rat liver and hepatoma polysome-membrane interaction invitro

1966 • 52 citations

Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones.

1980 • 52 citations

Prediction of the three-dimensional structure of the leader sequence of pre-kappa light chain, a hexadecapeptide.

1982 • 51 citations

Site of synthesis of rat liver NADH—cytochrome b₅ reductase, an integral membrane protein

1980 • 51 citations

Signal recognition particle-dependent insertion of coronavirus E1, an intracellular membrane glycoprotein.

1985 • 50 citations

Structural properties of signal peptides and their membrane insertion

1980 • 50 citations

Physical and conformational properties of a synthetic leader peptide from M13 coat protein

1984 • 49 citations

The binding of ribosomal subunits to endoplasmic reticulum membranes

1972 • 49 citations

Synthesis in vitro and Translocation of Apolipoprotein AI across Microsomal Vesicles

1981 • 49 citations

Phospholipid is required for the processing of presecretory proteins by detergent-solubilized canine pancreatic signal peptidase.

1981 • 49 citations

Signal Peptide Digestion in Escherichia coli

1982 • 49 citations

Similarity and Limited Multiplicity of Membrane Proteins from Rough and Smooth Endoplasmic Reticulum

1970 • 48 citations

Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes.

1979 • 47 citations

Effects of replacing serine and threonine residues within the signal peptide on the secretion of the major outer membrane lipoprotein of Escherichia coli.

1984 • 47 citations

Invitro translation of epoxide hydratase messenger RNA

1980 • 47 citations

Cleavage of honeybee prepromelittin by an endoprotease from rat liver microsomes: identification of intact signal peptide.

1982 • 46 citations

Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli

1984 • 46 citations

Cellular processing of pre-proparathyroid hormone involves rapid hydrolysis of the leader sequence.

1979 • 46 citations

Structure of the signal recognition particle by electron microscopy.

1985 • 45 citations

Membrane‐Dependent Cleavage of the Human Placental Lactogen Precursor to Its Native Form in Ascites Cell‐Free Extracts

1977 • 44 citations

Reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase: location of the hydrophobic, membrane-binding region at the carboxyl-terminal end and the masked amino terminus

1978 • 44 citations

Cloning and expression of a gene coding for the prolipoprotein signal peptidase of Escherichia coli

1983 • 43 citations

Different Modes of Membrane Interactions of the Signal Sequence of Carp Preproinsulin and of the Insertion Sequence of Rabbit Cytochrome b₅

1982 • 41 citations

Mobility of ribosomes bound to microsomal membranes. A freeze-etch and thin-section electron microscope study of the structure and fluidity of the rough endoplasmic reticulum.

1977 • 41 citations

Identification of Ribophorins in Rough Microsomal Membranes from Different Organs of Several Species

1982 • 40 citations

Processing in vitro of placental peptide hormones by smooth microsomes.

1979 • 40 citations

Cloning and characterization of cDNA copies of the 7S RNAs of HeLa cells

1982 • 38 citations

Electrophoretic studies on liver endoplasmic reticulum membrane polypeptides and on their phosphorylation in vivo and in vitro.

1978 • 37 citations

Pushing the signal hypothesis: what are the limits?

1985 • 37 citations

Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins

1984 • 37 citations

Evolutionary conservation of the human 7 S RNA sequences

1982 • 37 citations

Studies on the intracellular segregation of polyribosome-associated messenger ribonucleic acid species in the lactating guinea-pig mammary gland

1979 • 36 citations

Demonstration of Specific Receptors of the Rough Endoplasmic Membrane for the Signal Sequence of Carp Preproinsulin

1980 • 36 citations

Intracellular and Intramembranous Localization of a Protein Disulfide Isomerase in Rat Liver

1981 • 36 citations

Site of biosynthesis of cytochrome P450 in hepatocytes of phenobarbital treated rats

1976 • 35 citations

Signal recognition particle triggers the translocation of storage globulin polypeptides from field beans (Vicia faba L.) across mammalian endoplasmic reticulum membrane

1984 • 31 citations

Restriction of docking protein to the rough endoplasmic reticulum: immunocytochemical localization in rat liver.

1985 • 31 citations

The signal hypothesis — a working model

1982 • 31 citations

Biogenesis of plasmalemmal glycoproteins. Intracellular site of synthesis of mouse liver plasmalemmal 5′-nucleotidase as determined by the sub-cellular location of messenger RNA coding for 5′-nucleotidase

1975 • 30 citations

Processing of prepromelittin by subcellular fractions from rat liver

1978 • 30 citations

Transport of an uncleaved preprotein into the endoplasmic reticulum of rat pituitary cells.

1981 • 30 citations

Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane

1980 • 30 citations

Localization and Biosynthesis of NADH-Cytochrome b(5) reductase, an integral membrane protein, in rat liver cells. III. Evidence for the independent insertion and turnover of the enzyme in various subcellular compartments

1980 • 29 citations

Early events in the cellular formation of proparathyroid hormone

1980 • 29 citations

On the Involvement of Cytochrome P‐450 in the Binding of Ribosomes to a Subfraction of Rat‐Liver Rapidly Sedimenting Endoplasmic Reticulum

1977 • 28 citations

Synthesis of Immunoglobulins by Membrane‐Bound Polysomes and Free Polysomes from Plasmacytoma Cells

1973 • 27 citations

The major outer membrane lipoprotein and new lipoproteins share a common signal peptidase that exists in the cytoplasmic membrane of Escherichia coli

1984 • 27 citations

Identification of protein disulphide-isomerase as a major acidic polypeptide in rat liver microsomal membranes

1983 • 27 citations

Characterization of the association of two small molecular weight RNAs with eukaryotic polysomes.

1981 • 26 citations

Membrane-bound ribosomes of myeloma cells. II. Kinetic studies on the entry of newly made ribosomal subunits into the free and the membrane-bound ribosomal particles.

1975 • 25 citations

Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle

1983 • 25 citations

Cell-free processing and segregation of insulin precursors.

1983 • 24 citations

Segregation of Specific Classes of Messenger RNA into Free and Membrane‐Bound Polysomes

1981 • 24 citations

A receptor for signal segments of secretory proteins in rough endoplasmic reticulum membranes

1981 • 23 citations

Circular dichroism studies on synthetic signal peptides

1985 • 21 citations

Mammalian Signal Peptidase: Partial Purification and General Characterization of the Signal Peptidase from Microsomal Membranes of Porcine Pancreas1

1984 • 21 citations

Recognition of signal sequences

1983 • 20 citations

Conformational studies of the synthetic hydrophobic sequences in signal peptides of secretory proteins

1984 • 20 citations

Ribosome binding sites visualized on freeze-fractured membranes of the rough endoplasmic reticulum.

1980 • 19 citations

Synthetic leader peptide modulates secretion of proteins from microinjected Xenopus oocytes.

1983 • 19 citations

In vitro synthesis and post-translational insertion into microsomes of the integral membrane protein, NADH-cytochrome b5 oxidoreductase.

1983 • 19 citations

Recovery of ribophorins and ribosomes in "inverted rough" vesicles derived from rat liver rough microsomes.

1982 • 18 citations

alpha-Amylase biosynthesis: evidence for temporal sequence of NH2-terminal peptide cleavage and protein glycosylation.

1982 • 18 citations

Binding of Polysomes In Vitro with Endoplasmic Membrane Prepared from Rat Liver

1977 • 17 citations

Biosynthesis and Turnover of a Microsomal Protein Disulfide Isomerase in Rat Liver

1981 • 17 citations

Transport and cleavage of bacterial pre-β-lactamase by mammalian microsomes

1983 • 17 citations

Enzymatic processing of precursors of ovine lactoproteins by mammary microsomal membranes and a deoxycholate‐soluble extract from rough microsomes

1979 • 17 citations

Transfer of carbohydrates on to nascent glycoprotein of vesicular stomatitis virus

1979 • 14 citations

Isolation and characterization of membrane proteins responsible for attachment of polyribosomes to rough microsomal fraction of rat liver

1977 • 13 citations

An Anti‐(Signal Peptide) Antibody: Purification, Properties and Use as a Conformational Probe

1979 • 11 citations

Hepatic Membrane Proteins Involved in Ribosome Binding: Identification by Three Procedures

1979 • 9 citations

Peptide products of the cleavage of bovine preprolactin by signal peptidase

1985 • 7 citations

Properties of Rat Liver Signal Peptidase Reconstituted into Liposomes

1985 • 6 citations