A new look at lipid-membrane structure in relation to drug research.

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

2013 • 3,867 citations

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

1996 • 1,581 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes

1997 • 1,396 citations

Liposomes in drug delivery: Progress and limitations

1997 • 1,156 citations

Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol

1973 • 986 citations

Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective

1991 • 849 citations

A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

1997 • 754 citations

Mattress model of lipid-protein interactions in membranes

1984 • 734 citations

Fate and behavior of liposomes in vivo: a review of controlling factors.

1987 • 594 citations

Transfersomes, Liposomes and Other Lipid Suspensions on the Skin: Permeation Enhancement, Vesicle Penetration, and Transdermal Drug Delivery

1996 • 494 citations

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

1992 • 454 citations

The Lateral Pressure Profile in Membranes: A Physical Mechanism of General Anesthesia

1997 • 453 citations

The "Stealth" Liposome: A Prototypical Biomaterial

1995 • 406 citations

Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol)

1995 • 379 citations

Cell surface organization by the membrane skeleton

1996 • 378 citations

Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

1979 • 360 citations

Lateral Pressures in Cell Membranes: A Mechanism for Modulation of Protein Function

1997 • 356 citations

Dynamical order and disorder in lipid bilayers

1994 • 311 citations

Molecular mechanism of the lipid vesicle longevity in vivo

1993 • 305 citations

Transdermal drug carriers: Basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides

1995 • 286 citations

Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers.

1994 • 282 citations

Membrane Stiffness and Channel Function

1996 • 280 citations

Membrane bending energy concept of vesicle‐ and cell‐shapes and shape‐transitions

1994 • 271 citations

The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting

1989 • 261 citations

Liposomes in gene therapy

1996 • 258 citations

Where do general anaesthetics act?

1978 • 255 citations

Relationships between lipid membrane area, hydrophobic thickness, and acyl-chain orientational order. The effects of cholesterol

1990 • 252 citations

Lipid microdomains in cell surface membranes

1997 • 245 citations

Structure, Stability, and Thermodynamics of Lamellar DNA-Lipid Complexes

1998 • 230 citations

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains

1996 • 223 citations

Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol)

1995 • 220 citations

Cationic lipid-based gene delivery systems: pharmaceutical perspectives.

1997 • 214 citations

Theoretical analysis of protein organization in lipid membranes

1998 • 211 citations

The relationship between permeant size and permeability in lipid bilayer membranes

1994 • 210 citations

Recent advances in liposomal drug-delivery systems

1995 • 197 citations

Direct NMR Evidence for Ethanol Binding to the Lipid-Water Interface of Phospholipid Bilayers

1994 • 194 citations

Systematic Relationship between Phospholipase A₂ Activity and Dynamic Lipid Bilayer Microheterogeneity

1996 • 186 citations

Passive ion permeability of lipid membranes modelled via lipid-domain interfacial area

1988 • 184 citations

Curvature-induced lateral phase segregation in two-component vesicles

1993 • 183 citations

Lipid dynamics and peripheral interactions of proteins with membrane surfaces

1994 • 148 citations

Lipid Bilayer Electrostatic Energy, Curvature Stress, and Assembly of Gramicidin Channels

1997 • 146 citations

Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.

1978 • 142 citations

Fluidity of the lipid domain of cell wall from Mycobacterium chelonae.

1995 • 141 citations

Phospholipase A2 as a mechanosensor

1995 • 139 citations

Bending membranes to the task: structural intermediates in bilayer fusion

1995 • 136 citations

Phosphatidylcholine and Phosphatidylethanolamine Behave as Substrates of the Human MDR1 P-Glycoprotein

1997 • 136 citations

A Model Membrane Approach to the Epidermal Permeability Barrier

1994 • 133 citations

Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol

1989 • 132 citations

Intrinsic curvature in normal and inverted lipid structures and in membranes

1996 • 131 citations

Phase separation dynamics and lateral organization of two-component lipid membranes

1995 • 129 citations

Density fluctuations in saturated phospholipid bilayers increase as the acyl-chain length decreases

1990 • 123 citations

Small-scale lipid-membrane structure: simulation versus experiment

1997 • 117 citations

Permeability of dimyristoyl phosphatidylcholine/dipalmitoyl phosphatidylcholine bilayer membranes with coexisting gel and liquid-crystalline phases

1995 • 110 citations

Molecular sorting of lipids by bacteriorhodopsin in dilauroylphosphatidylcholine/distearoylphosphatidylcholine lipid bilayers

1997 • 109 citations

Phase equilibria and local structure in binary lipid bilayers

1993 • 107 citations

Estimation of molecular averages and equilibrium fluctuations in lipid bilayer systems from the excess heat capacity function

1978 • 103 citations

Inhibition of phospholipase A ₂

1994 • 99 citations

On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases

1996 • 99 citations

Effect of Bilayer Composition on the Phase Behavior of Liposomal Suspensions Containing Poly(ethylene glycol)-Lipids

1995 • 97 citations

Anomalous swelling of multilamellar lipid bilayers in the transition region by renormalization of curvature elasticity

1994 • 91 citations

Evidence for the formation of microdomains in liquid crystalline large unilamellar vesicles caused by hydrophobic mismatch of the constituent phospholipids

1996 • 88 citations

Liposomes as a carrier for intracellular delivery of antisense oligonucleotides: a real or magic bullet?

1996 • 88 citations

Partition of lindane in synthetic and native membranes

1985 • 87 citations

Different distribution of fluorinated anesthetics and nonanesthetics in model membrane: a 19F NMR study

1997 • 84 citations

The Influence of Polymer-Grafted Lipids on the Physical Properties of Lipid Bilayers: A Theoretical Study

1994 • 82 citations

Parameters influencing the introduction of plasmid DNA into cells by the use of synthetic amphiphiles as a carrier system

1995 • 81 citations

Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures

1988 • 81 citations

Lipid‐protein interactions in membranes

1990 • 81 citations

Indirect evidence for lipid-domain formation in the transition region of phospholipid bilayers by two-probe fluorescence energy transfer

1996 • 76 citations

The effect of anaesthetics on the dynamic heterogeneity of lipid membranes

1993 • 75 citations

Contrasting membrane localization and behavior of halogenated cyclobutanes that follow or violate the Meyer-Overton hypothesis of general anesthetic potency

1997 • 73 citations

Micro-, nano- and meso-scale heterogeneity of iipid bilayers and its influence on macroscopic membrane properties

1995 • 73 citations

Direct Detection of Domains in Phospholipid Bilayers by Grazing Incidence Diffraction of Neutrons and Atomic Force Microscopy

1998 • 73 citations

Orientation and Diffusion of a Drug Analog in Biomembranes: Molecular Dynamics Simulations

1995 • 72 citations

Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation

1996 • 71 citations

Topology of gel-phase domains and lipid mixing properties in phase-separated two-component phosphatidylcholine bilayers

1996 • 67 citations

Chapter 8 Influence of Nonlamellar-Forming Lipids on Rhodopsin

1997 • 64 citations

Wetting and capillary condensation as means of protein organization in membranes

1997 • 64 citations

The influence of physical characteristics of liposomes containing doxorubicin on their pharmacological behavior

1990 • 63 citations

[9] Phospholipase A2 activity and physical properties of lipid-bilayer substrates

1997 • 61 citations

Origin of the Lag Period in the Phospholipase C Cleavage of Phospholipids in Membranes. Concomitant Vesicle Aggregation and Enzyme Activation

1996 • 60 citations

Detection of phase separation in fluid phosphatidylserine/phosphatidylcholine mixtures

1994 • 60 citations

The effects of ethylene oxide containing lipopolymers and tri-block copolymers on lipid bilayers of dipalmitoylphosphatidylcholine

1997 • 60 citations

Self-assembly and organization of lipid-protein membranes

1998 • 59 citations

Formation of Membrane Domains during the Activation of Protein Kinase C

1996 • 59 citations

Stresses in lipid membranes and interactions between inclusions

1995 • 57 citations

Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes

1992 • 56 citations

An NMR and DSC study of the interaction of phospholipid vesicles with some anti-inflammatory agents

1990 • 55 citations

Nicotinic acetylcholine receptor channels are influenced by the physical state of their membrane environment

1996 • 55 citations

Azone® induced fluidity in human stratum corneum. A fourier transform infrared spectroscopy investigation using the perdeuterated analogue

1996 • 54 citations

Structure and dynamic properties of diunsaturated 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine lipid bilayer from molecular dynamics simulation

1997 • 54 citations

Models of stratum corneum intercellular membranes: The sphingolipid headgroup is a determinant of phase behavior in mixed lipid dispersions

1992 • 53 citations

How has molecular pharmacology contributed to our understanding of the mechanism(s) of general anesthesia?

1996 • 52 citations

Functional roles of non-lamellar forming lipids

1996 • 52 citations

Role of Lipid Organization and Dynamics for Membrane Functionality

1996 • 51 citations

Association of spin-labeled local anesthetics at the hydrophobic surface of the acetylcholine receptor in native membranes from Torpedo marmorata

1990 • 51 citations

Increase in phospholipase A 2 activity towards lipopolymer-containing liposomes

1998 • 46 citations

Enhancement of Agkistrodon piscivorus piscivorus venom phospholipase A2 activity toward phosphatidylcholine vesicles by lysolecithin and palmitic acid: Studies with fluorescent probes of membrane structure

1995 • 43 citations

Association of ethanol with lipid membranes containing cholesterol, sphingomyelin and ganglioside: a titration calorimetry study

1999 • 42 citations

Activation of Protein Kinase C by Coexisting Diacylglycerol-Enriched and Diacylglycerol-Poor Lipid Domains

1997 • 34 citations

Temperature- and pH-controlled fusion between complex lipid membranes. Examples with the diacylphosphatidylcholine/fatty acid mixed liposomes

1994 • 30 citations

Lindane suppresses the lipid-bilayer permeability in the main transition region

1996 • 30 citations

Slow Nonequilibrium Dynamical Rearrangement of the Lateral Structure of a Lipid Membrane

1996 • 30 citations

Solutes in small amounts provide for lipid-bilayer softness: cholesterol, short-chain lipids, and bola lipids

1996 • 29 citations

Fluorescence-quenching study of percolation and compartmentalization in two-phase lipid bilayers

1996 • 29 citations

Phase behavior and permeability properties of phospholipid bilayers containing a short-chain phospholipid permeability enhancer

1997 • 26 citations

Calorimetric and theoretical studies of the effects of lindane on lipid bilayers of different acyl chain length

1995 • 24 citations

The effects of phospholipid unsaturation and alcohol perturbation at the protein/lipid interface probed using fluorophore lifetime heterogeneity

1994 • 23 citations

Influence of the intrinsic membrane protein bacteriorhodopsin on gel-phase domain topology in two-component phase-separated bilayers

1997 • 22 citations

Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores

1997 • 20 citations

The effects of calcium channel blocking drugs on the thermotropic behavior of dimyristoylphosphatidylcholine

1989 • 18 citations

Treatment of Experimental Bladder Cancer with Hyperthermia and Phase Transition Liposomes Containing Methotrexate

1988 • 18 citations

Influence of oligopeptide transporter binding affinity upon uptake and transport of d-Asp(OBzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

1997 • 15 citations

Fluorescence quenching and electron spin resonance study of percolation in a two-phase lipid bilayer containing bacteriorhodopsin

1997 • 14 citations

Effect of Lipid Composition on Insulin-Mediated Fusion of Small Unilamellar Liposomes: A Kinetic Study

1988 • 12 citations

Mechanisms of actions of anaesthetic drugs

1997 • 6 citations

Agent Targeting by Means of the Chemically or Physically Directed, Fusogenic Liposomes

1996 • 4 citations

Drug and anesthetic effects on membrane structure and function (Advances in membrane fluidity, Vol. 5)

1991 • 4 citations

Effects of Incorporation of Lutein and 8‐Methoxypsoralen into Erythrocyte and Liposomal Membranes

1996 • 3 citations

A general model for lipid-mediated two-dimensional array formation of membrane proteins

1998 • 1 citations