Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

1984 • 638 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Structure of tumour necrosis factor

1989 • 512 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Efficient oligonucleotide-directed construction of mutations in expression vectors by the gapped duplex DNA method using alternating selectable markers

1989 • 321 citations

Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome.

1978 • 282 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

The history, properties, and biological effects of cachectin

1988 • 143 citations

Tumour necrosis factor is a compact trimer

1987 • 136 citations

A high molecular weight component of the human tumor necrosis factor receptor is associated with cytotoxicity.

1987 • 85 citations

Mutational analysis of structure—activity relationships in human tumor necrosis factor-alpha

1990 • 80 citations

Molecular weight of recombinant human tumor necrosis factor-alpha.

1987 • 60 citations

Tumor Necrosis Factor Structure, Mechanism of Action, Role in Disease and Therapy

1991 • 57 citations

Protein structure, folding and design 2

1988 • 48 citations

Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).

1988 • 48 citations

Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction

1988 • 39 citations

Antibodies against amino acids 1-15 of tumor necrosis factor block its binding to cell-surface receptor.

1987 • 38 citations

Lymphokines and Monokines in Anti-cancer Therapy

1986 • 36 citations

Role of single disulfide in recombinant human tumor necrosis factor-alpha.

1987 • 34 citations

Improvement of cytotoxicity of tumor necorosis factor (TNF) by increase in basicity of its N-terminal region

1987 • 26 citations

Comparative Studies of the Biological Activities of Human Tumor Necrosis Factor and Its Derivatives

1987 • 24 citations

[22] An improved method to obtain a large number of mutants in a defined region of DNA

1987 • 22 citations

Crystallization and preliminary X-ray investigation reveals that tumor necrosis factor is a compact trimer furnished with 3-fold symmetry

1988 • 21 citations

Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: General properties and epitope analysis

1990 • 20 citations

Histidine-15: an important role in the cytotoxic activity of human tumor necrosis factor

1989 • 17 citations

Use of a sensitive receptor binding assay to discriminate between full-length and truncated human recombinant tumor necrosis factor proteins.

1987 • 16 citations

Conserved residues of tumour necrosis factor and lymphotoxin constitute the framework of the trimeric structure

1989 • 12 citations

Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity

1988 • 9 citations

[21] Site-specific mutagenesis to modify the human tumor necrosis factor gene

1987 • 9 citations