Soluble kit receptor in human serum

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity

1981 • 4,191 citations

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

1986 • 647 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

1991 • 333 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

1990 • 304 citations

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

1991 • 265 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Expression of c-kit receptor in normal and transformed human nonlymphoid tissues.

1992 • 208 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 202 citations

Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile

1991 • 188 citations

Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues.

1993 • 185 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 176 citations

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.

1992 • 167 citations

Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors

1992 • 160 citations

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

1991 • 155 citations

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

1991 • 153 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

Soluble stem cell factor in human serum

1993 • 151 citations

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

1992 • 134 citations

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.

1992 • 130 citations

Preparation and characterization of hetero-bifunctional cross-linking reagents for protein modifications.

1981 • 127 citations

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

1993 • 115 citations

Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor

1992 • 113 citations

Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor

1992 • 111 citations

Cloning and structural analysis of the human c-kit gene.

1992 • 105 citations

Interspecies molecular chimeras of kit help define the binding site of the stem cell factor.

1993 • 81 citations

Soluble hormone receptors [editorial; comment]

1993 • 78 citations

[43] Cross-linking of ribosomes using 2-iminothiolane (methyl 4-mercaptobutyrimidate) and identification of cross-linked proteins by diagonal polyacrylamide/sodium dodecyl sulfate gel electrophoresis

1979 • 74 citations

Ligand and Protein Kinase C Downmodulate the Colony-Stimulating Factor 1 Receptor by Independent Mechanisms

1989 • 70 citations

Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.

1993 • 66 citations

Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III.

1992 • 66 citations

Absence of abnormalities of c-kit or its ligand in two patients with Diamond-Blackfan anemia

1992 • 62 citations

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.

1992 • 57 citations

Purification and characterization of soluble forms of human and rat stem cell factor recombinantly expressed by Escherichia coli and by Chinese hamster ovary cells

1992 • 53 citations

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma

1993 • 49 citations

Cloning and expression of the chicken c-kit proto-oncogene

1993 • 40 citations

Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells

1992 • 38 citations

Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.

1992 • 34 citations

Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor

1993 • 29 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 22 citations

Soluble stem cell factor in human serum

1993 • 20 citations

Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor

1992 • 13 citations

Absence of abnormalities of c-kit or its ligand in two patients with Diamond-Blackfan anemia

1992 • 5 citations

Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor

1993 • 2 citations