Renal Acidification Mechanisms
Data up to Jan 2025
Total Citations Per Year
Abstract
References (432)
Climatic Impact of Tropical Lowland Deforestation on Nearby Montane Cloud Forests
2001 • 1,128 citations
Water Permeation Across Biological Membranes: Mechanism and Dynamics of Aquaporin-1 and GlpF
2001 • 844 citations
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger
1998 • 839 citations
REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
1997 • 726 citations
THE EXCRETION OF ACID IN RENAL DISEASE
1959 • 687 citations
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness
1999 • 669 citations
Inherited susceptibility to uterine leiomyomas and renal cell cancer
2001 • 641 citations
Evolutionary origins of eukaryotic sodium/proton exchangers
2005 • 539 citations
Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion
2001 • 526 citations
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
2006 • 453 citations
Renal Vacuolar H+-ATPase
2004 • 434 citations
cAMP-mediated inhibition of the epithelial brush border Na + /H + exchanger, NHE3, requires an associated regulatory protein
1997 • 426 citations
Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing
2000 • 402 citations
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
2002 • 395 citations
Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchanger
1981 • 388 citations
Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase.
1989 • 378 citations
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast
2000 • 345 citations
Localization of a proton-pumping ATPase in rat kidney.
1988 • 343 citations
Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.
1984 • 338 citations
Plasticity of functional epithelial polarity
1985 • 334 citations
Physiology and pathophysiology of the calcium-sensing receptor in the kidney
2009 • 333 citations
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
2006 • 327 citations
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting
2002 • 326 citations
The Distribution of Glutaminase Isoenzymes in the Various Structures of the Nephron in Normal, Acidotic, and Alkalotic Rat Kidney
1973 • 319 citations
Phosphate transport by isolated renal brush border vesicles
1976 • 311 citations
Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss
2002 • 305 citations
Transport of organic anions across the basolateral membrane of proximal tubule cells
2003 • 297 citations
Renal handling of citrate
1990 • 291 citations
Sodium and potassium ion pump in kidney tubules.
1980 • 285 citations
The renal cell primary cilium functions as a flow sensor
2003 • 273 citations
Structural-functional relationships along the distal nephron
1986 • 270 citations
Bone buffering of acid and base in humans
2003 • 260 citations
Organic Acids in Man
1982 • 256 citations
NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes
2005 • 250 citations
Carbonic Anhydrase II Binds to the Carboxyl Terminus of Human Band 3, the Erythrocyte Cl−/HCO3−Exchanger
1998 • 244 citations
Relative CO 2 /NH 3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
2009 • 243 citations
Cell membranes impermeable to NH3
1989 • 243 citations
Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney.
1990 • 240 citations
THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. IV. THE NATURE OF THE RENAL COMPENSATIONS IN AMMONIUM CHLORIDE ACIDOSIS 1
1949 • 231 citations
Deoxycorticosterone Upregulates PDS ( Slc26a4 ) in Mouse Kidney
2003 • 224 citations
The role of carbonic anhydrases in renal physiology
2006 • 224 citations
Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways
2001 • 222 citations
BICARBONATE AND THE RENAL REGULATION OF ACID BASE BALANCE
1946 • 221 citations
The Role of NHERF and E3KARP in the cAMP-mediated Inhibition of NHE3
1998 • 214 citations
Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat.
1991 • 214 citations
Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells.
1992 • 212 citations
Molecular physiology and genetics of Na+-independent SLC4 anion exchangers
2009 • 210 citations
Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect.
1983 • 200 citations
Cloning and Functional Expression of a Human Kidney Na+:HCO3−Cotransporter
1997 • 197 citations
Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics.
1988 • 195 citations
NaCl Restriction Upregulates Renal Slc26a4 Through Subcellular Redistribution
2004 • 193 citations
Phenotype analysis of aquaporin-8 null mice
2005 • 192 citations
Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice
1999 • 189 citations
Identification of the Erythrocyte Rh Blood Group Glycoprotein as a Mammalian Ammonium Transporter
2002 • 188 citations
A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility
2008 • 183 citations
Renal expression of novel Na+/H+exchanger isoform NHE8
2003 • 183 citations
PDZK1: I. A major scaffolder in brush borders of proximal tubular cells11See Editorial by Moe, p. 1916.
2003 • 178 citations
Acid-Base Transport by the Renal Proximal Tubule
2006 • 178 citations
The Extracellular Component of a Transport Metabolon
2002 • 175 citations
Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A.
1998 • 175 citations
Roles and mechanisms of urinary buffer excretion
1987 • 175 citations
Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro.
1977 • 174 citations
Direct Extracellular Interaction between Carbonic Anhydrase IV and the Human NBC1 Sodium/Bicarbonate Co-Transporter
2003 • 173 citations
Intercalated Cell Subtypes in Connecting Tubule and Cortical Collecting Duct of Rat and Mouse
1999 • 171 citations
Micropuncture analysis of single-nephron function in NHE3-deficient mice
1999 • 168 citations
The Net Balance of Acid in Subjects Given Large Loads of Acid or Alkali*
1965 • 167 citations
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
2002 • 167 citations
Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney
2003 • 165 citations
The renal excretion of hydrogen ion in renal tubular acidosis
1960 • 164 citations
Localization of membrane-associated carbonic anhydrase type IV in kidney epithelial cells.
1990 • 161 citations
Human Rhesus-associated glycoprotein mediates facilitated transport of NH 3 into red blood cells
2004 • 158 citations
Localization of pendrin in mouse kidney
2003 • 155 citations
SLC4 base (HCO3−, CO32−) transporters: classification, function, structure, genetic diseases, and knockout models
2006 • 153 citations
Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues
2007 • 151 citations
Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney
1996 • 151 citations
Rh Type B Glycoprotein Is a New Member of the Rh Superfamily and a Putative Ammonia Transporter in Mammals
2001 • 150 citations
The B1 Subunit of the H+ATPase Is a PDZ Domain-binding Protein
2000 • 150 citations
RhBG and RhCG, the Putative Ammonia Transporters, Are Expressed in the Same Cells in the Distal Nephron
2003 • 147 citations
Molecular Mechanisms of Renal Ammonia Transport
2006 • 147 citations
Bicarbonate transport in cortical and outer medullary collecting tubules
1983 • 147 citations
A New Member of the HCO <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:msubsup><mml:mrow /><mml:mrow><mml:mn>3</mml:mn></mml:mrow><mml:mrow><mml:mo>−</mml:mo></mml:mrow></mml:msubsup></mml:math>Transporter Superfamily Is an Apical Anion Exchanger of β-Intercalated Cells in the Kidney
2001 • 145 citations
Characterization of Human RhCG and Mouse Rhcg as Novel Nonerythroid Rh Glycoprotein Homologues Predominantly Expressed in Kidney and Testis
2000 • 145 citations
Dopamine Acutely Stimulates Na+/H+Exchanger (NHE3) Endocytosis via Clathrin-coated Vesicles
2001 • 145 citations
Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.
1988 • 143 citations
Regulation of the V-ATPase in kidney epithelial cells: dual role in acid–base homeostasis and vesicle trafficking
2009 • 140 citations
Non-polarized targeting of AE1 causes autosomal dominant distal renal tubular acidosis
2003 • 139 citations
The B1-subunit of the H+ATPase is required for maximal urinary acidification
2005 • 139 citations
Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.
1993 • 139 citations
Acute Regulation of Na+/H+ Exchanger NHE3 by Parathyroid Hormone via NHE3 Phosphorylation and Dynamin-dependent Endocytosis
2000 • 138 citations
Intrarenal and Cellular Localization of CLC-K2 Protein in the Mouse Kidney
2001 • 137 citations
Relationship of renal ammonia production and potassium homeostasis
1977 • 136 citations
Role of NH3and NH4+transporters in renal acid-base transport
2010 • 134 citations
Angiotensin II binding sites in individual segments of the rat nephron.
1986 • 133 citations
The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis
2009 • 133 citations
The Effects of Dietary Excesses in Animal Protein and Sodium on the Composition and the Crystallization Kinetics of Calcium Oxalate Monohydrate in Urines of Healthy Men*
1990 • 133 citations
Signaling pathways in the biphasic effect of angiotensin II on apical Na/H antiport activity in proximal tubule
1996 • 132 citations
Expression of RhCG, a New Putative NH3/NH4 + Transporter, along the Rat Nephron
2002 • 131 citations
Modular structure of sodium-coupled bicarbonate transporters
2009 • 129 citations
Metabolon disruption: a mechanism that regulates bicarbonate transport
2005 • 128 citations
Genetic Investigation of Autosomal Recessive Distal Renal Tubular Acidosis
2006 • 127 citations
The Cl−/HCO3−exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance
2004 • 126 citations
Renal carbonic anhydrase
1982 • 125 citations
Regulation of AE1 anion exchanger and H+-ATPase in rat cortex by acute metabolic acidosis and alkalosis
1997 • 125 citations
Mechanism of increased renal gene expression during metabolic acidosis
2001 • 123 citations
Kidney amino acid transport
2009 • 123 citations
The renal H+-K+-ATPases: physiology, regulation, and structure
2009 • 122 citations
Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation
1978 • 121 citations
Nongenomic stimulation of vacuolar H + -ATPases in intercalated renal tubule cells by aldosterone
2004 • 119 citations
Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver
2003 • 117 citations
Ammonia production by individual segments of the rat nephron.
1984 • 117 citations
Glutamine metabolism: Role in acid‐base balance*
2004 • 117 citations
Ammonium Transport by the Thick Ascending Limb of Henle's Loop
1994 • 116 citations
Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA)
2004 • 115 citations
NH3 Is Involved in the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:msubsup><mml:mi>NH</mml:mi><mml:mrow><mml:mn>4</mml:mn></mml:mrow><mml:mo>+</mml:mo></mml:msubsup></mml:math> Transport Induced by the Functional Expression of the Human Rh C Glycoprotein
2004 • 115 citations
Immunolocalization of AE2 anion exchanger in rat kidney
1997 • 114 citations
Identification of distinct subpopulations of intercalated cells in the mouse collecting duct.
1996 • 114 citations
Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney
2000 • 113 citations
Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3loading
2003 • 113 citations
Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites
2005 • 113 citations
Electroneutral ammonium transport by basolateral rhesus B glycoprotein
2004 • 112 citations
Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption
2008 • 111 citations
Luminal secretion of ammonia in the mouse proximal tubule perfused in vitro.
1988 • 111 citations
Mechanosensory function of microvilli of the kidney proximal tubule
2004 • 110 citations
Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG
2005 • 109 citations
H-K-ATPase immunoreactivity in cortical and outer medullary collecting duct
1990 • 109 citations
Distribution of mineralocorticoid and glucocorticoid receptor mRNA along the nephron
1993 • 108 citations
Regulation of Thick Ascending Limb Ion Transporter Abundance in Response to Altered Acid/Base Intake
1999 • 107 citations
Role of Na+/H+exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3
2000 • 107 citations
Deletion of the pH Sensor GPR4 Decreases Renal Acid Excretion
2010 • 107 citations
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron
2001 • 106 citations
The stoichiometry of the electrogenic sodium bicarbonate cotransporter NBC1 is cell‐type dependent
2001 • 106 citations
Immunolocalization of the Na+/H+exchanger isoform NHE2 in rat kidney
1998 • 106 citations
AE4 is a DIDS-sensitive Cl−/HCO 3 − exchanger in the basolateral membrane of the renal CCD and the SMG duct
2002 • 106 citations
Modelling the human rhesus proteins: implications for structure and function
2005 • 104 citations
Regulation of intracellular pH in the rabbit cortical collecting tubule.
1990 • 103 citations
Aquaporin-8-facilitated mitochondrial ammonia transport
2010 • 103 citations
Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice
1995 • 102 citations
Localization of a Gene for Autosomal Recessive Distal Renal Tubular Acidosis with Normal Hearing (rdRTA2) to 7q33-34
1999 • 99 citations
Ammonium transport in the kidney
1991 • 99 citations
Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract
2004 • 98 citations
Chronic metabolic acidosis upregulates rat kidney Na-HCO 3 − cotransporters NBCn1 and NBC3 but not NBC1
2002 • 97 citations
Mechanism of angiotensin II action on proximal tubular transport.
1990 • 96 citations
Potassium depletion increases luminal Na+/H+ exchange and basolateral Na+:CO3=:HCO3- cotransport in rat renal cortex.
1990 • 96 citations
Carbonic anhydrase histochemistry in rabbit and mouse kidneys
1982 • 95 citations
Immunoelectron Microscopic Localization of the Electrogenic Na/HCO3 Cotransporter in Rat and Ambystoma Kidney
2000 • 95 citations
Macula densa Na+/H+exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms
2000 • 94 citations
Dietary Cl−restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells
2006 • 93 citations
Different Transport Mechanisms in Plant and Human AMT/Rh-type Ammonium Transporters
2006 • 93 citations
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule
1982 • 92 citations
Localization and Regulation of the ATP6V0A4 (a4) Vacuolar H+-ATPase Subunit Defective in an Inherited Form of Distal Renal Tubular Acidosis
2003 • 92 citations
Transport of citrate across renal brush border membrane: effects of dietary acid and alkali loading
1985 • 91 citations
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion
2009 • 91 citations
Expression of the 56-kDa B2 subunit isoform of the vacuolar H+-ATPase in proton-secreting cells of the kidney and epididymis
2004 • 90 citations
Glucocorticoids acutely increase cell surface Na+/H+exchanger-3 (NHE3) by activation of NHE3 exocytosis
2005 • 90 citations
Transport of NH3/NH 4 + in oocytes expressing aquaporin-1
2001 • 89 citations
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis
2005 • 89 citations
Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition
2001 • 88 citations
Genomic Organization and Glucocorticoid Transcriptional Activation of the Rat Na+/H+ Exchanger Nhe3 Gene
1996 • 88 citations
Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro
1985 • 88 citations
SLC26A7: a basolateral Cl-/HCO3-exchanger specific to intercalated cells of the outer medullary collecting duct
2004 • 88 citations
Physiology and molecular biology of renal carbonic anhydrase.
2002 • 87 citations
Hereditary Distal Renal Tubular Acidosis: New Understandings
2001 • 87 citations
Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney
1996 • 87 citations
Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion
2005 • 87 citations
Effect of acute respiratory acidosis on two populations of intercalated cells in rat cortical collecting duct
1987 • 87 citations
Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
2001 • 86 citations
Regulation of the apical Cl−/HCO 3 − exchanger pendrin in rat cortical collecting duct in metabolic acidosis
2003 • 86 citations
Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat
1998 • 85 citations
Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells
2005 • 85 citations
Nerve Tissue‐Specific (GLUD2) and Housekeeping (GLUD1) Human Glutamate Dehydrogenases Are Regulated by Distinct Allosteric Mechanisms
2000 • 84 citations
Functional characterization of three intercalated cell subtypes in the rabbit outer cortical collecting duct.
1994 • 84 citations
Bicarbonate transport by isolated perfused rat collecting ducts
1985 • 84 citations
Molecular mechanism of kNBC1–carbonic anhydrase II interaction in proximal tubule cells
2004 • 83 citations
Effect of Human Carbonic Anhydrase II on the Activity of the Human Electrogenic Na/HCO3 Cotransporter NBCe1-A in Xenopus Oocytes
2006 • 83 citations
Characteristics of renal Rhbg as an NH4+ transporter
2004 • 83 citations
Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule
2003 • 83 citations
Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments
2005 • 83 citations
Phosphorylation of Ser982 in the sodium bicarbonate cotransporter kNBC1 shifts the HCO3- : Na+ stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells
2001 • 82 citations
Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis
2006 • 82 citations
Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli
2009 • 82 citations
Impaired trafficking of distal renal tubular acidosis mutants of the human kidney anion exchanger kAE1
2002 • 82 citations
Immunolocalization of the secretory isoform of Na-K-Cl cotransporter in rat renal intercalated cells.
1996 • 81 citations
Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats
2002 • 80 citations
The thick ascending limb as a site of renal bicarbonate reabsorption.
1993 • 80 citations
Glutaminase: A multifaceted protein not only involved in generating glutamate
2006 • 79 citations
Evidence against a Direct Interaction between Intracellular Carbonic Anhydrase II and Pure C-terminal Domains of SLC4 Bicarbonate Transporters
2006 • 78 citations
Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter
1998 • 78 citations
Angiotensin II Stimulates Vacuolar H+-ATPase Activity in Renal Acid-Secretory Intercalated Cells from the Outer Medullary Collecting Duct
2007 • 78 citations
Inhibition of bicarbonate absorption by peptide hormones and cyclic adenosine monophosphate in rat medullary thick ascending limb.
1990 • 77 citations
Angiotensin II regulates H(+)-ATPase activity in rat cortical collecting duct
1994 • 77 citations
Regulation of renal amino acid transporters during metabolic acidosis
2006 • 76 citations
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency
2009 • 75 citations
Molecular pathophysiology of SLC4 bicarbonate transporters
2005 • 75 citations
Regulation of Intestinal Phosphate Transport II. Metabolic acidosis stimulates Na+-dependent phosphate absorption and expression of the Na+-Pi cotransporter NaPi-IIb in small intestine
2005 • 75 citations
Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression
2007 • 74 citations
Cyclic adenosine monophosphate-stimulated bicarbonate secretion in rabbit cortical collecting tubules.
1985 • 74 citations
Immunolocalization of electroneutral Na-HCO3−cotransporter in rat kidney
2000 • 73 citations
A mathematical model of rat distal convoluted tubule. I. Cotransporter function in early DCT
2005 • 72 citations
Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport
2006 • 72 citations
Effect of luminal bicarbonate concentration on proximal acidification in the rat
1982 • 71 citations
Expression of the Ammonia Transporter, Rh C Glycoprotein, in Normal and Neoplastic Human Kidney
2006 • 71 citations
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice
2007 • 70 citations
Angiotensin II Activates H+-ATPase in Type A Intercalated Cells
2008 • 70 citations
Functional roles of apical membrane Na+/H+ exchange in rat medullary thick ascending limb
1996 • 70 citations
Intercalated cells of the rat inner medullary collecting duct
1987 • 70 citations
Stoichiometry of the rat kidney Na + -HCO 3 - cotransporter expressed in Xenopus laevis oocytes
1999 • 69 citations
NHE4 is critical for the renal handling of ammonia in rodents
2010 • 69 citations
Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes
2009 • 69 citations
NH+4 transport mediated by Na(+)-K(+)-ATPase in rat inner medullary collecting duct
1994 • 69 citations
Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter
1991 • 69 citations
The renal Na-HCO 3 -cotransporter expressed in Xenopus laevis oocytes: change in stoichiometry in response to elevation of cytosolic Ca 2+ concentration
2001 • 69 citations
The Effects of Selective Depletion of Hydrochloric Acid on Acid-Base and Electrolyte Equilibrium *
1964 • 69 citations
Activation of acid-secreting intercalated cells in rabbit collecting duct with ammonium chloride loading
1994 • 68 citations
Mechanism of ammonia secretion by cortical collecting ducts of rabbits
1984 • 68 citations
Stimulation by in Vivo and in VitroMetabolic Acidosis of Expression of rBSC-1, the Na+-K+(NH4+)-2Cl−Cotransporter of the Rat Medullary Thick Ascending Limb
1998 • 68 citations
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis
2009 • 67 citations
Oligomeric Structure and Minimal Functional Unit of the Electrogenic Sodium Bicarbonate Cotransporter NBCe1-A
2008 • 67 citations
NH4+ transport in the kidney.
1991 • 67 citations
Effect of Potassium Deficiency on the Reabsorption of Bicarbonate in the Proximal Tubule of the Rat Kidney*
1964 • 67 citations
THE EFFECT OF THE ADMINISTRATION OF SODIUM BICARBONATE AND AMMONIUM CHLORIDE ON THE EXCRETION AND PRODUCTION OF AMMONIA. THE ABSENCE OF ALTERATIONS IN THE ACTIVITY OF RENAL AMMONIA-PRODUCING ENZYMES IN THE DOG
1959 • 66 citations
Angiotensin II stimulates vesicular H + -ATPase in rat proximal tubular cells
1998 • 66 citations
Vacuolar H+-ATPase d2 Subunit
2005 • 65 citations
Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II
1995 • 64 citations
Out-of-equilibrium CO2/HCO3− solutions and their use in characterizing a new K/HCO3 cotransporter
1995 • 64 citations
The Rh gene family and renal ammonium transport
2004 • 63 citations
Basolateral membrane Na+/H+ antiport, Na+/base cotransport, and Na+-independent Cl-/base exchange in the rabbit S3 proximal tubule.
1989 • 63 citations
Bicarbonate transport by proximal tubules: effect of parathyroid hormone and dibutyryl cyclic AMP
1980 • 63 citations
Recent advances in our understanding of intercalated cells
2005 • 63 citations
Role of PDZK1 in membrane expression of renal brush border ion exchangers
2005 • 62 citations
Ammonium as a substrate for Na+-K+-ATPase in rabbit proximal tubules
1986 • 62 citations
Preliminary Communication
1953 • 61 citations
Profound hypokalemia and hypochloremic metabolic alkalosis during thiazide therapy in a child with Pendred syndrome
2008 • 60 citations
Basolateral expression of the ammonia transporter family member Rh C glycoprotein in the mouse kidney
2009 • 60 citations
Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats
2002 • 60 citations
Mechanism of Genetic Complementation of Ammonium Transport in Yeast by Human Erythrocyte Rh-associated Glycoprotein
2004 • 60 citations
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes
2000 • 60 citations
Tethering, recycling and activation of the epithelial sodium–proton exchanger, NHE3
2009 • 59 citations
Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis
2006 • 59 citations
Immunohistochemical localization of H-K-ATPase α2c-subunit in rabbit kidney
2001 • 59 citations
An Overview of Divalent Cation and Citrate Handling by the Kidney
2004 • 59 citations
The location of glutamine synthetase within the rat and rabbit nephron
1978 • 58 citations
Bicarbonate transport along the loop of Henle. I. Microperfusion studies of load and inhibitor sensitivity.
1991 • 58 citations
Tubular reabsorption of l-glutamine studied by free-flow micropuncture and microperfusion of rat kidney
1980 • 58 citations
Axial heterogeneity of sodium-bicarbonate cotransporter expression in the rabbit proximal tubule
1998 • 58 citations
Adaptation of HCO-3 and NH+4 transport in rat MTAL: effects of chronic metabolic acidosis and Na+ intake
1990 • 58 citations
Bicarbonate transport along the loop of Henle. II. Effects of acid-base, dietary, and neurohumoral determinants.
1994 • 56 citations
Distal renal tubular acidosis
2004 • 56 citations
Colonic H-K-ATPase β-subunit: identification in apical membranes and regulation by dietary K depletion
1999 • 56 citations
Kidney collecting duct acid-base “regulon”
2006 • 55 citations
H(+)-K(+)-ATPase activity in rat collecting duct segments
1992 • 55 citations
Acidosis Activation of the Pituitary-Adrenal-Renal Glutaminase I Axis
1976 • 55 citations
Contribution of the Na+-K+-2Cl− Cotransporter (NKCC1) to Transepithelial Transport of H+, NH4 +, K+, and Na+ in Rat Outer Medullary Collecting Duct
2002 • 55 citations
Casein Kinase 2 Binds to the C Terminus of Na+/H+exchanger 3 (NHE3) and Stimulates NHE3 Basal Activity by Phosphorylating a Separate Site in NHE3
2008 • 55 citations
Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney
2009 • 55 citations
Glutamine synthetase and glutamyltransferase in the kidney of man, dog, and rat
1976 • 55 citations
NBCn1 is a basolateral \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{Na}^{+}\mathrm{-HCO}_{3}^{-}\) \end{document} cotransporter in rat kidney inner medullary collecting ducts
2004 • 54 citations
The Ammonium Transporter RhBG
2004 • 54 citations
Expression and cellular localization of mRNA encoding the "gastric" isoform of H(+)-K(+)-ATPase alpha-subunit in rat kidney
1995 • 54 citations
Renal response to metabolic acidosis: Role of mRNA stabilization
2007 • 54 citations
Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria
1998 • 53 citations
Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney
2000 • 53 citations
Hyposmolality stimulates Na+/H+exchange and HCO3−absorption in thick ascending limb via PI 3-kinase
2000 • 51 citations
Basolateral membrane Na+/H+ exchange enhances HCO3- absorption in rat medullary thick ascending limb: evidence for functional coupling between basolateral and apical membrane Na+/H+ exchangers.
1995 • 51 citations
NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase
1999 • 51 citations
Evidence from renal proximal tubules that \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation*}{\mathrm{HCO}}_{3}^{-}\end{equation*}\end{document} and solute reabsorption are acutely regulated not by pH but by basolateral \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb…
2005 • 50 citations
The Basolateral NHE1 Na+/H+ Exchanger Regulates Transepithelial <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:msubsup><mml:mtext>HCO</mml:mtext><mml:mn>3</mml:mn><mml:mo>−</mml:mo></mml:msubsup></mml:math> Absorption through Actin Cytoskeleton Remodeling in Renal Thick Ascending Limb
2005 • 50 citations
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