Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.

Intracellular pH.

1981 • 2,440 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney

1976 • 665 citations

Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.

1983 • 549 citations

Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchanger

1981 • 388 citations

Rheogenic sodium-bicarbonate cotransport in the peritubular cell membrane of rat renal proximal tubule

1985 • 288 citations

Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.

1985 • 266 citations

Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange.

1983 • 258 citations

Properties of the Na+-H+ exchanger in renal microvillus membrane vesicles

1980 • 252 citations

Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.

1986 • 237 citations

Intracellular pH transients in giant barnacle muscle fibers

1977 • 219 citations

Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption.

1987 • 176 citations

Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.

1987 • 174 citations

Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis.

1987 • 127 citations

Bicarbonate transport by isolated perfused rabbit proximal convoluted tubules

1977 • 119 citations

An ATP-driven proton pump in brush-border membranes from rat renal cortex

1982 • 115 citations

Luminal secretion of ammonia in the mouse proximal tubule perfused in vitro.

1988 • 111 citations

Apical Na+/H+ antiporter and glycolysis-dependent H+-ATPase regulate intracellular pH in the rabbit S3 proximal tubule.

1987 • 105 citations

Adaptation of Na+-H+ exchange in renal microvillus membrane vesicles. Role of dietary protein and uninephrectomy.

1984 • 104 citations

Na+-H+ exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: The role of glucocorticoids.

1984 • 104 citations

Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration.

1986 • 94 citations

Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes.

1987 • 93 citations

Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus.

1986 • 93 citations

Na+/H+ antiporter of brush border vesicles: studies with acridine orange uptake

1982 • 92 citations

Electrogenic sodium/bicarbonate cotransport in rabbit renal cortical basolateral membrane vesicles.

1986 • 88 citations

Relationship between sodium and bicarbonate transport in the rat proximal convoluted tubule

1981 • 78 citations

Electrophysiology of basolateral bicarbonate transport in the rabbit proximal tubule

1986 • 78 citations

HCO3- transport in basolateral membrane vesicles isolated from rat renal cortex.

1987 • 73 citations

Metabolic acidosis and parathyroidectomy increase Na+-H+ exchange in brush border vesicles

1983 • 72 citations

Effect of luminal bicarbonate concentration on proximal acidification in the rat

1982 • 71 citations

Increased Vmax for Na+/H+ antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosis

1984 • 68 citations

Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.

1983 • 67 citations

Renal Acidification Mechanisms

2012 • 61 citations

Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule.

1987 • 60 citations

Mechanism of bicarbonate exit across basolateral membrane of rabbit proximal straight tubule

1987 • 53 citations

Electrogenic Na/HCO3 cotransport across basolateral membrane of isolated perfused Necturus proximal tubule

1987 • 45 citations

Ammonia transport by early and late proximal convoluted tubule of the rat.

1987 • 40 citations

Intracellular pH in the isolated perfused rabbit proximal straight tubule

1985 • 40 citations

Proximal reabsorption during metabolic acidosis in the rat

1982 • 38 citations

Peritubular pH and PCO'2 in renal tubular acidification

1975 • 35 citations

Effect of metabolic acidosis on proximal tubular total CO2 absorption

1985 • 34 citations

Chronic hypercapnia enhances Vmax of Na-H antiporter of renal brush-border membranes

1987 • 34 citations

pH gradient-dependent increased Na+-H+ antiport capacity of the rabbit remnant kidney

1985 • 31 citations

Mechanism of bicarbonate exit across basolateral membrane of the rabbit proximal convoluted tubule

1984 • 23 citations

Na+-H+ exchange in luminal-membrane vesicles from rabbit proximal convoluted and straight tubules in response to metabolic acidosis

1986 • 22 citations

Proximal tubule hydrogen ion transport processes in diuretic-induced metabolic alkalosis.

1985 • 10 citations