Dysfunction of the Release of Endothelium-Derived Relaxing Factor

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Personal communication

1989 • 2,984 citations

Influence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events

1986 • 2,691 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Physiological aspects of primary hypertension.

1982 • 1,787 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

Platelet Activation in Unstable Coronary Disease

1986 • 1,161 citations

Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

1985 • 1,106 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

1986 • 892 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.

1983 • 845 citations

Coronary Vasospasm as a Possible Cause of Myocardial Infarction

1978 • 845 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease

1981 • 597 citations

Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.

1982 • 545 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts

1988 • 540 citations

Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

1991 • 538 citations

Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits.

1986 • 535 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

Endothelium-derived relaxing factor and coronary vasospasm.

1989 • 423 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.

1983 • 414 citations

Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates.

1986 • 406 citations

Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.

1987 • 404 citations

Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine

1983 • 372 citations

A clinical safety trial of stroma‐free hemoglobin

1978 • 361 citations

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro.

1987 • 358 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Coronary Vascular Reactivity After Acute Myocardial Ischemia

1982 • 336 citations

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

1990 • 312 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

1987 • 303 citations

Increased Adventitial Mast Cells in a Patient with Coronary Spasm

1985 • 298 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.

1988 • 265 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension.

1990 • 254 citations

Local coronary supersensitivity to diverse vasoconstrictive stimuli in patients with variant angina.

1986 • 252 citations

Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat.

1990 • 250 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

1991 • 243 citations

Imbalance of Endothelium-derived Relaxing and Contracting Factors: A New Concept in Hypertension?

1990 • 243 citations

Fibrinopeptide A and platelet factor levels in unstable angina pectoris.

1987 • 233 citations

Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110.

1986 • 219 citations

Coronary Arteries of Cardiac Patients Are Hyperreactive and Contain Stores of Amines: A Mechanism for Coronary Spasm

1984 • 213 citations

Thromboxane A2 receptor antagonists inhibit endothelium-dependent contractions.

1990 • 205 citations

The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion.

1980 • 203 citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy.

1988 • 200 citations

Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension.

1987 • 196 citations

Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.

1991 • 194 citations

Incubation with endotoxin activates the L-arginine pathway in vascular tissue

1990 • 193 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats.

1988 • 193 citations

Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium

1989 • 191 citations

Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats

1984 • 189 citations

Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery.

1988 • 185 citations

Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.

1989 • 185 citations

Endothelial control of vascular tone in large and small coronary arteries

1990 • 184 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit.

1987 • 182 citations

Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway

1990 • 182 citations

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus

1989 • 174 citations

Alterations in endothelium-dependent responsiveness of the canine basilar artery after subarachnoid hemorrhage

1988 • 168 citations

Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension

1987 • 164 citations

Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats.

1988 • 157 citations

Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure.

1988 • 157 citations

Endothelium-dependent and independent relaxation of aortic rings from hypertensive rats

1986 • 154 citations

Diabetes and Atherosclerosis: an Overview

1981 • 146 citations

Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion.

1989 • 146 citations

Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins.

1985 • 145 citations

Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury

1988 • 142 citations

Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries.

1990 • 138 citations

Vascular reactivity in diabetes mellitus: role of the endothelial cell

1983 • 134 citations

Selective hypercontraction caused by ergonovine in the canine coronary artery under conditions of induced atherosclerosis.

1984 • 132 citations

The natural history of endothelial structure and function in arterialized vein grafts

1986 • 130 citations

Role of platelets and platelet inhibitors in aortocoronary artery vein-graft disease.

1986 • 129 citations

Atrial natriuretic factor prevents NaCl-sensitive hypertension in spontaneously hypertensive rats.

1990 • 123 citations

Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries

1989 • 123 citations

Impairment of endothelium-dependent vasodilation induced by acetylcholine and adenosine triphosphate following experimental subarachnoid hemorrhage.

1987 • 119 citations

Endothelium-Dependent Reactivity in Resistance Vessels

2015 • 112 citations

Endothelium-derived contracting factor: endothelin and/or superoxide anion?

1988 • 109 citations

Endothelium-derived relaxing and contracting factors: Perspectives in nephrology

1991 • 108 citations

Indomethacin Improves the Impaired Endothelium-dependent Relaxations in Small Mesenteric Arteries of the Spontaneously Hypertensive Rat

1990 • 108 citations

Release of endothelium-derived relaxing factor after subarachnoid hemorrhage

1989 • 107 citations

Influence of the endothelium on contractile responses of arteries from diabetic rats

1988 • 106 citations

Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension.

1988 • 102 citations

Mechanism of histamine actions in human coronary arteries.

1987 • 102 citations

The natural history of endothelial structure and function in arterialized vein grafts

1986 • 102 citations

Subarachnoid hemorrhage inhibition of endothelium-derived relaxing factor in rabbit basilar artery

1988 • 101 citations

Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats.

1986 • 100 citations

Different interactions of platelets with arterial and venous coronary bypass vessels

1991 • 98 citations

Endothelium-dependent relaxation of human pulmonary arteries

1987 • 95 citations

Ergonovine-induced myocardial ischemia: no role for serotonergic receptors?

1984 • 93 citations

Hypercholesterolemia causes generalized impairment of endothelium-dependent relaxation to aggregating platelets in porcine arteries

1989 • 92 citations

Endothelium-derived relaxing factor and protection against contractions induced by histamine and serotonin in the human internal mammary artery and in the saphenous vein.

1989 • 90 citations

Modulation of vascular tonus by the endothelium in experimental diabetes

1987 • 88 citations

Endothelial Vasoactive Substances and Cardiovascular Disease

1988 • 88 citations

Endothelium-dependent relaxation and experimental atherosclerosis in the rabbit aorta

1986 • 85 citations

Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.

1988 • 84 citations

Effect of subarachnoid hemorrhage on endothelium-dependent vasodilation

1987 • 82 citations

Impaired endothelium-dependent relaxations in rabbits subjected to aortic coarctation hypertension.

1987 • 82 citations

Endothelial regulation of cyclic GMP and vascular responses in hypertension.

1988 • 82 citations

Pathophysiology of Acute Renal Failure

1977 • 79 citations

Endothelial modulation of vascular relaxation to nitrovasodilators in aging and hypertension.

1986 • 78 citations

Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog.

1987 • 77 citations

Reactivity of Aorta and Mesenteric Microvessels to Drugs in Spontaneously Hypertensive Rats: Role of the Endothelium

1987 • 76 citations

Vascular reactivity in diabetes mellitus: possible role of insulin on the endothelial cell

1984 • 72 citations

Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs.

1988 • 68 citations

Matrix-derived soluble components influence type II pneumocytes in primary culture

1989 • 67 citations

Vascular relaxation and cGMP in hypertension

1988 • 67 citations

Endothelium-dependent relaxation of canine basilar arteries. Part 2: Inhibition by hemoglobin and cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.

1987 • 64 citations

Influence of diabetes on the reactivity of mesenteric microvessels to histamine, bradykinin and acetylcholine

1983 • 63 citations

Superoxide production by human umbilical vein endothelial cells in an anoxia-reoxygenation model

1989 • 61 citations

Increased vasodilator response to acetylcholine of renal blood vessels from diabetic rats

1988 • 60 citations

Immunoreactive Endothelin-1 in Plasma Detected by a Sandwich-Type Enzyme Immunoassay

1989 • 59 citations

Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: Role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins

1988 • 57 citations

Hemolysate Inhibits Cerebral Artery Relaxation

1988 • 55 citations

Blood platelets in human essential hypertension

1986 • 55 citations

Endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium.

1989 • 54 citations

Decreased uptake of 3H-serotonin and endogenous content of serotonin in blood platelets in hypertensive patients.

1984 • 53 citations

Evidence for the role of endothelium-derived relaxing factor in acetylcholine-induced vasodilatation in the intact lung.

1987 • 52 citations

Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries

1989 • 49 citations

Interaction Between Endothelium-Derived Nitric Oxide and SIN-1 in Human and Porcine Blood Vessels

1989 • 49 citations

Preservation of endothelial cell structure and function by intracoronary perfluorochemical in a canine preparation of reperfusion.

1987 • 49 citations

Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine

1986 • 47 citations

Decreased responsiveness of the aortae of hypertensive rats to acetylcholine, histamine and noradrenaline

1987 • 46 citations

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

1986 • 45 citations

Modulatory role of the vascular endothelium in the contractility of human isolated internal mammary artery

1988 • 41 citations

Prostacyclin production by internal mammary artery as a factor in coronary artery bypass grafts.

1986 • 41 citations

Interaction Between Endothelium-Derived Nitric Oxide and SIN-1 in Human and Porcine Blood Vessels

1989 • 41 citations

Changes in Vascular Reactivity in Experimental Diabetic Rats: Comparison with Hypothyroid Rats

1988 • 40 citations

Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats

1984 • 39 citations

Contractions of isolated canine coronary arteries resistant to S2-serotonergic blockade.

1986 • 38 citations

Effects of hypertension and hypercholesterolemia on vasodilatation in the rabbit.

1986 • 38 citations

Influence of experimental diabetes on the mechanical responses of canine coronary arteries: role of endothelium

1988 • 36 citations

Impaired cholinergic vasodilation in the cholesterol-fed rabbit in vivo

1987 • 36 citations

Accumulation of 5-hydroxytryptamine leads to dysfunction of adrenergic nerves in canine coronary artery following intimal damage in vivo.

1987 • 35 citations

Platelets in Human Essential Hypertension: in vitro Hyperreactivity to Thrombin

1986 • 32 citations

Tyrosine A14[125I]monoiodoinsulin: Preparation, Biologic Properties, and long-term stability

1981 • 30 citations

Dietary effect on platelet aggregation in men with and without a family history of essential hypertension.

1984 • 26 citations

Potentiating effects of extraluminal oxyhemoglobin to intraluminal 5-hydroxytryptamine in isolated canine internal carotid arteries

1988 • 23 citations

Development of a Large Fibromuscular Intimal Thickening Does Not Impair Endothelium-Dependent Relaxation in the Rabbit Carotid Artery

1987 • 22 citations

Relaxing and Contracting Factors: Biological and Clinical Research

1988 • 22 citations

Fibrinogen degradation products influence PGI synthesis by cultured porcine aortic endothelial and smooth muscle cells

1984 • 22 citations

The role of the endothelium in the control of venous tone: studies on isolated human veins

1988 • 21 citations

5-Hydroxytryptamine kinetics and activation of blood platelets in patients with essential hypertension.

1990 • 21 citations

Endothelium-Dependent Responses in Human Arteries

1988 • 16 citations

Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo

1988 • 15 citations

Endotheiium-dependent and independent relaxation effects on aorta preparations of renal hypertensive rats

1984 • 14 citations

Vascular Reactivity in Neonatal Spontaneously Hypertensive Rats1

2015 • 13 citations

Increases in Flow Reduce the Release of Endothelium-Derived Relaxing Factor in the Aorta of Normotensive and Spontaneously Hypertensive Rats

1989 • 11 citations

Age and the Platelet Serotonin Vasoconstrictor Axis in Essential Hypertension

1988 • 10 citations

Different interaction of platelets with arterial and venous coronary bypass grafts: Role of nitric oxide and antiplatelet drugs

1991 • 8 citations

Acute Dose-Response Curve of Enalapril in Renovascular Hypertensives

1988 • 7 citations

Age and the Platelet Serotonin Vasoconstrictor Axis in Essential Hypertension

1988 • 7 citations

Oxidized, but not native low density lipoproteins inhibit relaxations of porcine coronary arteries by a scavenger receptor dependent mechanism: Role of endothelium-derived nitric oxide

1991 • 5 citations

Endothelium-dependent relaxation effects in aorta from hypertensive rats

1984 • 5 citations

Direct Coronary Vasodilator Effects of Intracoronary Histamine Administration in Humans

1986 • 5 citations

Endothelium-dependent regulatory mechanisms in human coronary bypass grafts: possible clinical implications.

1989 • 4 citations

Response : Out of Africa: Honey Bee Hybrids

1992 • 1 citations