Endothelial control of vascular tone in large and small coronary arteries

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Role of endothelium in responses of vascular smooth muscle.

1983 • 1,975 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin

1983 • 855 citations

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.

1983 • 845 citations

Coronary Vasospasm as a Possible Cause of Myocardial Infarction

1978 • 845 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm.

1986 • 542 citations

Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts

1988 • 540 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

The discovery of nitric oxide as the endogenous nitrovasodilator.

1988 • 486 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine

1983 • 372 citations

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro.

1987 • 358 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets

1983 • 353 citations

Coronary Vascular Reactivity After Acute Myocardial Ischemia

1982 • 336 citations

Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells.

1984 • 330 citations

An endothelial cell-derived growth factor.

1980 • 316 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

1987 • 303 citations

Platelets, endothelium, and vasospasm.

1985 • 301 citations

Increased Adventitial Mast Cells in a Patient with Coronary Spasm

1985 • 298 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.

1988 • 265 citations

Anoxia and endothelium‐dependent reactivity of the canine femoral artery.

1983 • 259 citations

Local coronary supersensitivity to diverse vasoconstrictive stimuli in patients with variant angina.

1986 • 252 citations

Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine

1983 • 249 citations

Coronary Arteries of Cardiac Patients Are Hyperreactive and Contain Stores of Amines: A Mechanism for Coronary Spasm

1984 • 213 citations

The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion.

1980 • 203 citations

5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries

1983 • 194 citations

Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats.

1988 • 193 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway

1990 • 182 citations

The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia

1984 • 180 citations

Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture.

1986 • 177 citations

Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.

1981 • 166 citations

The Human Preproendothelin-1 Gene

1989 • 166 citations

Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries.

1987 • 166 citations

Vascular Endothelium in Hemostasis and Thrombosis

1987 • 165 citations

Prostacyclin releases endothelium‐derived relaxing factor and potentiates its action in coronary arteries of the pig

1988 • 154 citations

Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits

1989 • 154 citations

Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion.

1989 • 146 citations

Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets

1985 • 143 citations

Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid, and acetylcholine in canine basilar arteries.

1988 • 136 citations

The Discovery, the Present State, and the Future Prospects of Endothelin

1989 • 123 citations

Endothelium-Dependent Reactivity in Resistance Vessels

2015 • 112 citations

Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells

1981 • 111 citations

Acetylcholine-induced contractions in isolated rabbit pulmonary arteries: role of thromboxane A2.

1986 • 111 citations

Endothelium-derived contracting factor: endothelin and/or superoxide anion?

1988 • 109 citations

Mechanism of histamine actions in human coronary arteries.

1987 • 102 citations

Effects of Atenolol, Verapamil, and Xamoterol on Heart Rate and Exercise Tolerance in Digitalised Patients with Chronic Atrial Fibrillation

1989 • 95 citations

Possible Role of Endothelial Thromboxane A2 in the Resting Tone and Contractile Responses to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries

1987 • 92 citations

Endothelial Vasoactive Substances and Cardiovascular Disease

1988 • 88 citations

Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.

1988 • 84 citations

Does Endothelin-1 Mediate Endothelium-Dependent Contractions During Anoxia?

1989 • 82 citations

Release of different relaxing factors by cultured porcine endothelial cells.

1989 • 78 citations

Cholinergic mechanisms in human coronary artery preparations: implications of species differences.

1985 • 72 citations

Characterization of vascular relaxant factor released from cultured endothelial cells.

1987 • 71 citations

Anoxic Contractions in Isolated Canine Cerebral Arteries

1986 • 62 citations

Relaxing and Contracting Factors

1988 • 59 citations

Immunoreactive Endothelin-1 in Plasma Detected by a Sandwich-Type Enzyme Immunoassay

1989 • 59 citations

Endothelium-derived relaxing and contracting factors: potential role in coronary artery disease

1989 • 59 citations

The Mechanism of Action of Endothelin-1 as Compared with Other Agonists in Vascular Smooth Muscle

1989 • 58 citations

Reversal of acetycholine-induced coronary resistance vessel dilation by hemoglobin

1987 • 57 citations

Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: Role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins

1988 • 57 citations

Effects of endothelin on regional hemodynamics in conscious rats

1989 • 56 citations

Vascular Mechanism of Action of Endothelin-1

1989 • 53 citations

Preservation of endothelial cell structure and function by intracoronary perfluorochemical in a canine preparation of reperfusion.

1987 • 49 citations

Different Effects of Endothelin-1 on cAMP-and cGMP-Mediated Vascular Relaxation in Human Arteries and Veins

1989 • 48 citations

Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine

1986 • 47 citations

Mechanisms responsible for coronary vasospasm

1986 • 47 citations

Vascular endothelium, haemostasis and thrombosis

1988 • 44 citations

Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries.

1986 • 44 citations

Absence of role of endothelium in the response of isolated porcine coronary arteries to acetylcholine

1986 • 41 citations

Dietary ω3 polyunsaturated fatty acids augment endothelium‐dependent relaxation to bradykinin in coronary micro vessels of the pig

1988 • 38 citations

Flunarizine inhibits endothelium‐dependent hypoxic facilitation in canine coronary arteries through an action on vascular smooth muscle

1988 • 36 citations

Regulation of smooth muscle proliferative phenotype by heparinoid-matrix interactions

1988 • 31 citations

Transmural distribution of blood flow during activation of coronary muscarinic receptors

1981 • 27 citations

Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators.

1987 • 26 citations

Balance between endothelium-mediated dilating and direct constricting actions of serotonin on resistance vessels in the isolated rabbit heart

1987 • 24 citations

Relaxing and Contracting Factors: Biological and Clinical Research

1988 • 22 citations

Differential H1- and H2-receptor-mediated histamine responses of canine epicardial conductance and distal resistance coronary vessels.

1988 • 19 citations

Endothelium-Dependent Responses in Human Arteries

1988 • 16 citations

Na+-K+ exchanges in canine arterial and venous smooth muscle

1982 • 9 citations

Direct Coronary Vasodilator Effects of Intracoronary Histamine Administration in Humans

1986 • 5 citations

Stimulation of soluble guanylate cyclase activity by endothelium-derived relaxant factor: A general principle of its vasodilator and antiaggregatory properties

1987 • 4 citations

Effect of EDRF release from freshly harvested endothelial cells on the coronary circulation of the isolated working rabbit heart.

1988 • 3 citations