Changes in NF-kappa B and ISGF3 DNA binding activities are responsible for differences in MHC and beta-IFN gene expression in Ad5- versus Ad12-transformed cells.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

1983 • 353 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.

1990 • 249 citations

Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene.

1987 • 244 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.

1987 • 184 citations

ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR

1989 • 184 citations

A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.

1987 • 169 citations

Histocompatibility Antigens on Murine Tumors

1985 • 164 citations

A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.

1990 • 144 citations

A novel function of the transforming domain of E1a: Repression of AP-1 activity

1990 • 142 citations

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.

1991 • 138 citations

Activity of rat Mx proteins against a rhabdovirus

1990 • 136 citations

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

1982 • 126 citations

Expression of histocompatibility antigens H-2K, -D, and -L is reduced in adenovirus-12-transformed mouse cells and is restored by interferon gamma.

1985 • 111 citations

Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either

1990 • 110 citations

Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

1988 • 106 citations

Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon

1985 • 105 citations

Binding of a Nuclear Factor to a Regulatory Sequence in the Promoter of the Mouse H-2K^b Class I Major Histocompatibility Gene

1987 • 101 citations

Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts

1989 • 76 citations

Tumorigenicity of adenovirus-transformed cells: Region E1A of adenovirus 12 confers resistance to natural killer cells

1985 • 74 citations

Adenovirus E1A-mediated regulation of class I MHC expression.

1986 • 65 citations

Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer.

1988 • 63 citations

A Large Protein Containing Zinc Finger Domains Binds to Related Sequence Elements in the Enhancers of the Class I Major Histocompatibility Complex and Kappa Immunoglobulin Genes

1990 • 52 citations

Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC gene.

1990 • 52 citations

A Study to Determine the Reasons for Differences in the Tumorigenicity of Rat Cell Lines Transformed by Adenovirus 2 and Adenovirus 12

1980 • 52 citations

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

1990 • 46 citations

A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes.

1990 • 35 citations

Nuclear proteins binding to an enhancer element of the major histocompatibility class I promoter: Differences between highly oncogenic and nononcogenic adenovirus-transformed rat cells

1989 • 29 citations

Alteration of a single nucleotide allows efficient binding of H2TF1/KBF1 to the immunoglobulin kappa enhancer B motif.

1989 • 26 citations

Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells.

1986 • 22 citations

The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression

1990 • 16 citations

The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function

1990 • 14 citations

A Transcription Factor Interacting with the Class I Gene Enhancer Is Inactive in Tumorigenic Cell Lines Which Suppress Major Histocompatibility Complex Class I Genes

1990 • 12 citations

Alteration of a Single Nucleotide Allows Efficient Binding of H2TF1/KBF1 to the Immunoglobulin k Enhancer B Motif

1989 • 10 citations