The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

1983 • 467 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

1981 • 435 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus

1980 • 336 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

1981 • 237 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

1985 • 223 citations

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

1984 • 195 citations

HeLa Cell β-Tubulin Gene Transcription Is Stimulated by Adenovirus 5 in Parallel with Viral Early Genes by an E1a-Dependent Mechanism

1984 • 187 citations

Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

1984 • 186 citations

Cis-acting induction of adenovirus transcription

1983 • 180 citations

The structure of adenovirus 2 early nuclear and cytoplasmic RNAs

1980 • 177 citations

Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.

1984 • 167 citations

Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides

1986 • 166 citations

Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells.

1986 • 161 citations

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

1984 • 153 citations

Lytic and transforming functions of individual products of the adenovirus E1A gene

1986 • 136 citations

Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein.

1990 • 132 citations

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

1982 • 126 citations

Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts.

1985 • 119 citations

Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport

1985 • 117 citations

Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.

1988 • 88 citations

Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.

1989 • 84 citations

Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression.

1986 • 77 citations

Adenovirus E1A Coding Sequences That Enable ras and pmt Oncogenes To Transform Cultured Primary Cells

1986 • 72 citations

Effect on transformation of mutations in the early region 1b-encoded 21- and 55-kilodalton proteins of adenovirus 5

1984 • 60 citations

Regulation of Cellular Phenotype and Expression of Polyomavirus Middle T Antigen in Rat Fibroblasts

1985 • 60 citations

Role of Adenovirus E1B Proteins in Transformation: Altered Organization of Intermediate Filaments in Transformed Cells That Express the 19-Kilodalton Protein

1990 • 60 citations

Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum

1987 • 59 citations

Uptake, Fixation, and Expression of Foreign DNA in Mammalian Cells: The Organization of Integrated Adenovirus DNA Sequences

1982 • 54 citations

Cold-sensitive expression of transformation by a host range mutant of type 5 adenovirus.

1983 • 46 citations

The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression

1989 • 40 citations

Interactions Between Cell Growth-Regulating Domains in the Products of the Adenovirus E1A Oncogene

1988 • 38 citations

Cellular Promoters Incorporated into the Adenovirus Genome: Cell Specificity of Albumin and Immunoglobulin Expression

1986 • 32 citations

Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

1986 • 31 citations

Morphological Transformation of Established Rodent Cell Lines by High-Level Expression of the Adenovirus Type 2 E1a Gene

1986 • 14 citations

The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function

1990 • 14 citations

Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein

1988 • 10 citations