Polymorphisms of the Dopamine Transporter Gene

Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD.

1997 • 6,883 citations

A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder

1999 • 3,305 citations

Association of attention-deficit disorder and the dopamine transporter gene.

1995 • 1,023 citations

ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups

2001 • 952 citations

Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle

1996 • 846 citations

Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study

1998 • 844 citations

Neurobiology of attention-deficit hyperactivity disorder

1998 • 815 citations

Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain

2001 • 745 citations

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

1992 • 718 citations

Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

1998 • 686 citations

Attention Deficit Hyperactivity Disorder: Advances in Cognitive, Neurobiological, and Genetic Research

1998 • 612 citations

Is Methylphenidate Like Cocaine?

1995 • 575 citations

Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum

2000 • 550 citations

Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

2000 • 517 citations

Attention-deficit/hyperactivity disorder (adhd) as a noradrenergic disorder

1999 • 502 citations

Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism

1997 • 498 citations

Association and Linkage of the Dopamine Transporter Gene and Attention-Deficit Hyperactivity Disorder in Children: Heterogeneity owing to Diagnostic Subtype and Severity

1998 • 467 citations

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

1992 • 467 citations

The Contribution of α2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function

1996 • 466 citations

Dopamine genes and ADHD

2000 • 454 citations

Catecholamines in Attention-Deficit Hyperactivity Disorder: Current Perspectives

1996 • 449 citations

Neuropsychopharmacology

2003 • 430 citations

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression

2001 • 424 citations

Genetic basis of attention deficit and hyperactivity

1999 • 406 citations

Toward a Pathophysiology of Attention-Deficit/Hyperactivint Disorder

1997 • 399 citations

Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children

1999 • 390 citations

Attention Deficit Hyperactivity Disorder: Advances in Cognitive, Neurobiological, and Genetic Research

1998 • 365 citations

Attention-deficit/hyperactivity disorder: a life-span perspective.

1998 • 352 citations

Educational and Occupational Outcome of Hyperactive Boys Grown Up

1997 • 338 citations

Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT‐PCR

2002 • 337 citations

ADHD in a School Sample of Brazilian Adolescents: A Study of Prevalence, Comorbid Conditions, and Impairments

1999 • 336 citations

Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications

2001 • 315 citations

Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: an overview.

1998 • 311 citations

The Nature and Heritability of Attention-Deficit/Hyperactivity Disorder

2001 • 300 citations

Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment

2000 • 285 citations

Adoptive and Biological Families of Children and Adolescents With ADHD

2000 • 282 citations

Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report

2000 • 279 citations

A Spatial Hearing Deficit in Early-Blind Humans

2001 • 276 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

1999 • 256 citations

The Dopamine Theory of Attention Deficit Hyperactivity Disorder (ADHD)

1991 • 232 citations

Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression

2002 • 231 citations

Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis

2002 • 229 citations

Genetic Influences in Childhood-Onset Psychiatric Disorders: Autism and Attention-Deficit/Hyperactivity Disorder

1997 • 204 citations

Dopaminergic System Genes in ADHD Toward a Biological Hypothesis

2002 • 195 citations

The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons

2001 • 195 citations

The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans

2001 • 187 citations

Rating scales and checklists for child psychopharmacology.

1985 • 185 citations

Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder

2003 • 185 citations

Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3)

1999 • 184 citations

The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

2001 • 178 citations

Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 273 nuclear families from a multi-centre sample

2002 • 177 citations

Attention‐deficit hyperactivity disorder: A study of association with both the dopamine transporter gene and the dopamine D4 receptor gene

2001 • 175 citations

Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder

2001 • 172 citations

Dopamine genes and attention-deficit hyperactivity disorder: a review.

2003 • 159 citations

Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis

2002 • 157 citations

Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples

2001 • 156 citations

Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD

2003 • 153 citations

A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder

2000 • 152 citations

A 40-nucleotide repeat polymorphism in the human dopamine transporter gene

1993 • 146 citations

Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder

2002 • 137 citations

Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci

2003 • 124 citations

VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators

1998 • 121 citations

Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems

2003 • 118 citations

Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: Genetic analysis of the Milwaukee longitudinal study

2003 • 112 citations

Timing, Space and ADHD: The Dopamine Theory Revisited

2001 • 111 citations

Candidate genes in psychiatry: An epidemiological perspective

1993 • 108 citations

Is the α‐2A adrenergic receptor gene (ADRA2A) associated with attention‐deficit/hyperactivity disorder?

2003 • 102 citations

The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample

2003 • 101 citations

The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)

2002 • 98 citations

Genetics of Childhood Disorders: XXIII. ADHD, Part 7: The Serotonin System

2001 • 96 citations

Association study of a SNAP‐25 microsatellite and attention deficit hyperactivity disorder

2002 • 94 citations

Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms

2001 • 84 citations

No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins

2001 • 81 citations

No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample

1999 • 79 citations

Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention‐deficit/hyperactivity disorder: A pilot study

2003 • 74 citations

Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders

2000 • 45 citations

99A Quantitative Trait Locus Analysis of the Dopamine Transporter Gene in Adults with ADHD

2002 • 41 citations

Susceptibility genes for a trait measure of attention deficit hyperactivity disorder: a pilot study in a non-clinical sample of twins

2001 • 34 citations

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

2003 • 32 citations

Psychiatric pharmacogenetics: personalizing psychostimulant therapy in attention-deficit/hyperactivity disorder

2002 • 31 citations

The acute effect of methylphenidate in Brazilian male children and adolescents with ADHD: A randomized clinical trial

2004 • 29 citations

New phenotype definition of attention deficit hyperactivity disorder in relatives for genetic analyses

1996 • 21 citations

Attention-deficit/hyperactivity disorder: current aspects on pharmacogenetics

2003 • 11 citations