Thymus-independent antigens: complexity of B-lymphocyte activation revealed

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

Subclass Restriction of Murine Anti-Carbohydrate Antibodies

1978 • 428 citations

Contemporary Topics in Immunobiology

1977 • 410 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE

1972 • 349 citations

Genetics of the Antibody Response to Dextran in Mice

1972 • 348 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

1979 • 301 citations

Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide

1971 • 280 citations

Purification to apparent homogeneity of murine interleukin 1.

1981 • 257 citations

Mitogens in Immunobiology

1977 • 217 citations

CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES

1971 • 190 citations

T cell regulation of IgG subclass antibody production in response to T-independent antigens.

1981 • 181 citations

Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response.

1978 • 180 citations

Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

1977 • 178 citations

Surface Immunoglobulin D as a Functional Receptor for a Subclass of B Lymphocytes

1977 • 173 citations

The Ontogeny of Thymic Independent Antibody Responses in Vitro in Normal Mice and Mice with an X-Linked B Cell Defect

1977 • 171 citations

The immune system: Genes, receptors, signals

1973 • 169 citations

THE ROLE OF NONLYMPHOID ACCESSORY CELLS IN THE IMMUNE RESPONSE TO DIFFERENT ANTIGENS

1970 • 158 citations

Bound C3 as the second signal for B-cell activation

1973 • 158 citations

Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine

1972 • 157 citations

Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response.

1971 • 149 citations

INDUCTION OF IMMUNITY AND TOLERANCE IN VITRO BY HAPTEN PROTEIN CONJUGATES

1972 • 139 citations

CELLULAR REQUIREMENTS FOR THE PRIMARY IN VITRO ANTIBODY RESPONSE TO DNP-FICOLL

1974 • 134 citations

The Genetics of the Immune Response to a Synthetic Double-Stranded RNA in a Mutant CBA Mouse Strain

1973 • 123 citations

In Vitro Responses of CBA/N Mice: Spleen Cells of Mice with an X-Linked Defect that Precludes Immune Responses to Several Thymus-Independent Antigens Can Respond to TNP-Lipopolysaccharide

1976 • 113 citations

Induction of DNA synthesis in human lymphocytes: interaction between non-specific mitogens and antigens.

1970 • 107 citations

Role of T lymphocytes in the response to TNP-AECM-Ficoll.

1980 • 105 citations

Macrophages and T cells control distinct phases of B cell differentiation in the humoral immune response in vitro.

1980 • 102 citations

Activation of murine B lymphocytes. III. Stimulation of B lymphocyte clonal growth with lipopolysaccharide and dextran sulfate.

1981 • 100 citations

The genetic control of antibody variable regions in the mouse

1978 • 95 citations

Cells of immunoglobulin synthesis

1979 • 94 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

Macrophage Requirement for the in Vitro Response to TNP Ficoll: A Thymic Independent Antigen

1976 • 92 citations

Staphylococci and Staphylococcal Infections: Recent Progress

1975 • 90 citations

Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition

1981 • 82 citations

Tolerogenic or immunogenic activity of hapten‐conjugated polysaccharides correlated with cellular localization

1981 • 79 citations

Genetic and functional characterization of an antiserum to the lipid A‐specific triggering receptor on murine B lymphocytes

1978 • 77 citations

Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.

1980 • 77 citations

Idiotype of inulin-binding antibodies and myeloma proteins controlled by genes linked to the allotype locus of the mouse.

1976 • 77 citations

Two types of functionally distinct, synergizing helper T cells.

1980 • 76 citations

Role of accessory cells in B cell activation. I. Macrophage presentation of TNP-Ficoll: evidence for macrophage-B cell interaction.

1980 • 73 citations

Mitogens in immunobiology

1976 • 73 citations

The role of surface IgD in the response to thymic-independent antigens.

1977 • 66 citations

Idiotypes of Inulin-Binding Antibodies and Myeloma Proteins Controlled by Genes Linked to the Allotype Locus of the Mouse

1976 • 64 citations

Contemporary topics in immunobiology

1973 • 61 citations

Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens.

1979 • 59 citations

Persistence of immunogenicity of two complex antigens retained in vivo.

1968 • 57 citations

INDUCTION OF RABBIT ANTIBODY WITH MOLECULAR UNIFORMITY AFTER IMMUNIZATION WITH GROUP C STREPTOCOCCI

1970 • 57 citations

Primary in vitro antibody responses by purified murine B lymphocytes in serum-free defined medium.

1981 • 56 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1975 • 55 citations

Role of accessory cells in B cell activation. II. The interaction of B cells with accessory cells results in the exclusive activation of an Lyb5+ B cell subpopulation.

1980 • 54 citations

Role of Antigen Structure in the Discrimination between Tolerance and Immunity by B Cells

1975 • 51 citations

Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.

1980 • 51 citations

Induction of B Cell Priming by Neonatal Injection of Mice with Thymic-Independent (Type 2) Antigens

1978 • 47 citations

Lyb-2 system of mouse B cells. Evidence for a role in the generation of antibody-forming cells

1981 • 44 citations

Analysis of B Cell Activation Requirements with TNP-Conjugated Polyacrylamide Beads

1979 • 43 citations

Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).

1972 • 42 citations

Partial characterization and purification of murine T cell-replacing factor, TRF—II

1978 • 40 citations

C3 activation and T-independent B cell stimulation

1974 • 37 citations

The murine B cell response to TNP-polyacrylamide beads: the relationship between the epitope density of the antigen and the requirements for T cell help and surface IgD.

1980 • 34 citations

Antigen-induced T cell-replacing factor (TRF). II. X-linked gene control for the expression of TRF-acceptor site(s) on B lymphocytes and preparation of specific antiserum to that acceptor.

1980 • 30 citations

Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.

1978 • 27 citations

IgG B memory cell subpopulations: differences in susceptibility to stimulation by TI-1 and TI-2 antigens.

1980 • 27 citations

Cellular requirements for antigen presentation in the induction of a thymus-independent antibody response in vitro.

1980 • 18 citations

The immune response of CBA/N mice and their F₁ hybrids to 2,4,6‐trinitrophenylated (TNP) antigens I. Analysis of the response to TNP‐coupled lipopoly‐saccharide in vivo and at the clonal level

1979 • 16 citations

The influence of epitope density on the immunological properties of hapten-protein conjugates. II. The in vivo and in vitro metabolism of heavily and lightly conjugated protein.

1974 • 15 citations

Low doses of DNP-D-GL, a potent hapten-specific tolerogen, are immunogenic in vitro

1975 • 7 citations

Different Macrophage Requirement in the Specific and Polyclonal Responses Induced by TNP‐LPS and LPS

1980 • 7 citations