Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)

1964 • 1,213 citations

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1967 • 1,210 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

The purine and pyrimidine composition of deoxypentose nucleic acids

1951 • 1,084 citations

NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITY

1975 • 855 citations

Catechol-O-methyl transferase: pharmacological aspects and physiological role.

1975 • 547 citations

The Enzymatic Synthesis of S-Adenosyl-l-homocysteine from Adenosine and Homocysteine

1959 • 546 citations

The Role of Adenosine and 2'-Deoxyadenosine in Mammalian Cells

1978 • 518 citations

Labile methyl balances for normal humans on various dietary regimens

1975 • 492 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

[14] High-performance liquid chromatography of proteins

1983 • 381 citations

Polyamines in Mammalian Biology and Medicine

1979 • 295 citations

The Specificity of S-Adenosylmethionine Derivatives in Methyl Transfer Reactions

1969 • 281 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

Competing Methyltransferase Systems

1972 • 270 citations

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

1977 • 267 citations

Combined immunodeficiency disease associated with adenosine deaminase deficiency

1975 • 255 citations

THE NATURE OF THE ACTIVE METHYL DONOR FORMED ENZYMATICALLY FROM L-METHIONINE AND ADENOSINETRIPHOSPHATE^1,2

1952 • 252 citations

Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis

1973 • 248 citations

Ribosome binding to reovirus mRNA in protein synthesis requires 5′ terminal 7-methylguanosine

1975 • 241 citations

Inhibition of Transmethylations of Biogenic Amines by S-Adenosylhomocysteine

1971 • 239 citations

Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

1978 • 230 citations

Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.

1978 • 200 citations

The Enzymatic Conversion of Phospholipid Ethanolamine to Phospholipid Choline in Rat Liver

1961 • 193 citations

The Methylation of Nucleic Acids

1966 • 191 citations

METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER

1951 • 187 citations

S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors.

1977 • 182 citations

Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity

1979 • 178 citations

S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents

1980 • 174 citations

In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

1979 • 168 citations

Different sites of adenosine formation in the heart

1981 • 160 citations

Purine metabolism in adenosine deaminase deficiency.

1976 • 160 citations

Carbocyclic analog of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target

1982 • 158 citations

The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline.

1981 • 153 citations

Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines

1977 • 149 citations

S-Adenosylhomocysteine Metabolism in Various Species

1975 • 144 citations

IMMUNOLOGICAL OBSERVATIONS ON PATENTS WITH LESCH-NYHAN SYNDROME, AND ON THE ROLE OF DE-NOVO PURINE SYNTHESIS IN LYMPHOCYTE TRANSFORMATION

1975 • 143 citations

A Hydrolytic Nucleosidase Acting on S-Adenosylhomocysteine and on 5'-Methylthioadenosine

1962 • 141 citations

Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities.

1979 • 133 citations

Concanavalin A stimulates phospholipid methylation and phosphatidylserine decarboxylation in rat mast cells.

1979 • 132 citations

The Enzymatic Methylation of Ribonucleic Acid and Deoxyribonucleic Acid

1964 • 131 citations

Occurrence and distribution of methylated purines in the ribonucleic acids of subcellular fractions

1962 • 129 citations

A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC

1973 • 126 citations

S -Adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin

1979 • 124 citations

Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells.

1981 • 123 citations

A ROLE FOR PURINE METABOLISM IN THE IMMUNE RESPONSE: ADENOSINE-DEAMINASE ACTIVITY AND DEOXYADENOSINE CATABOLISM

1978 • 121 citations

Preparation of l-homocysteine from l-homocysteine thiolactone

1966 • 119 citations

Adenine and Adenosine Are Toxic to Human Lymphoblast Mutants Defective in Purine Salvage Enzymes

1977 • 112 citations

3-Deazaadenosine, an inhibitor of adenosylhomocysteine hydrolase, inhibits reproduction of rous sarcoma virus and transformation of chick embryo cells

1978 • 110 citations

Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemic basophils

1980 • 106 citations

Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts

1981 • 105 citations

Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts

1981 • 102 citations

Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

1978 • 97 citations

Adenosylhomocysteinase from Yellow Lupin Seeds

1977 • 96 citations

Mechanism for enzymatic thioether formation. Mechanism of action of S-adenosylhomocysteinase.

1976 • 95 citations

S-Adenosylhomocysteine hydrolase from rat liver. Purification and some properties.

1981 • 93 citations

The antifungal antibiotic sinefungin as a ver y active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by rous sarcoma virus

1978 • 92 citations

Quantitative analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues

1971 • 85 citations

5′‐Methylthioadenosine Nucleosidase

1981 • 85 citations

Adenosine deaminase inhibitors: Their role in chemotherapy and immunosuppression

1980 • 84 citations

Plasmodium falciparum: Antimalarial activity in culture of sinefungin and other methylation inhibitors

1980 • 80 citations

THE FORMATION OF S-ADENOSYLHOMOCYSTEINE IN ENZYMATIC TRANSMETHYLATION REACTIONS¹

1954 • 80 citations

The Regional Concentrations of S‐Adenosyl‐<scp>l</scp>‐Methionine, S‐Adenosyl‐<scp>l</scp>‐Homocysteine, and Adenosine in Rat Brain

1982 • 79 citations

Inactivation of S-Adenosylhomocysteine hydrolase by 5′-deoxy-5′-methylthioadenosine

1981 • 78 citations

Protein carboxymethylation: Role in the regulation of cell functions

1981 • 78 citations

Inhibition of Newcastle disease virion messenger RNA (guanine-7-)-methyltransferase by analogs of S-adenosylhomocysteine

1977 • 76 citations

Inhibition of virus-induced cell transformation by synthetic analogues of S-adenosyl homocysteine

1975 • 75 citations

Studies of nucleosides and nucleotides.

1974 • 73 citations

The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine

1980 • 72 citations

Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.

1980 • 72 citations

Binding proteins for cyclic AMP in mammalian tissues

1981 • 72 citations

Adenosine Deaminase Deficiency and Severe Combined Immunodeficiency Disease

1980 • 69 citations

Inhibition of Methylation by Adenosine in Adenosine Deaminase-Inhibited, Phytohemagglutinin-Stimulated Human Lymphocytes

1979 • 69 citations

Enhancement of the Biological Activity of Adenosine Analogs by the Adenosine Deaminase Inhibitor 2&amp;rsquo;-Deoxycoformycin

1977 • 66 citations

Methionine metabolism in mammals: Synthesis of S-adenosylhomocysteine in rat tissues

1973 • 62 citations

Purification and characterization of adenosine-adenosine cyclic 3',5'-monophosphate binding protein factors from rabbit erythrocytes

1974 • 62 citations

Adenosylhomocysteine hydrolase inhibitors: Synthesis of 5′-deoxy-5′-(isobutylthio)-3-deazaadenosine and its effect on Rous sarcoma virus and Gross murine leukemia virus

1978 • 62 citations

Alkaloids and Plant Metabolism

1963 • 61 citations

Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine

1978 • 61 citations

S-Ribosylhomocysteine Cleavage Enzyme from Escherichia coli

1968 • 60 citations

The Effect of Nucleosides and Deoxycoformycin on Adenosine and Deoxyadenosine Inhibition of Human Lymphocyte Activation

1979 • 60 citations

Convenient preparation of S-adenosylhomocysteine and related compounds

1976 • 60 citations

Inhibition of chemotaxis by S-3-deazaadenosylhomocysteine in a mouse macrophage cell line.

1982 • 59 citations

Guanidoacetate methyltransferase. Purification and molecular properties.

1979 • 59 citations

Purification and properties of S-adenosyl-l-homocysteine hydrolase from leaves of spinach beet

1976 • 58 citations

The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes

1975 • 58 citations

S-Adenosylhomocysteine inhibition of three purified tRNA methyltransferases from rat liver

1975 • 58 citations

Studies on inhibitors of mammalian tRNA methylases

1971 • 55 citations

Mutants of Chinese hamster cells resistant to adenosine

1975 • 53 citations

Adenosine-3': 5'-Monophosphate-Binding Proteins from Bovine Kidney. Isolation by Affinity Chromatography and Limited Proteolysis of the Regulatory Subunit of Protein Kinase II

1978 • 51 citations

Adenosine analogs as substrates and inhibitors of S-adenosylhomocysteine hydrolase in intact lymphocytes

1980 • 51 citations

Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs

1981 • 51 citations

Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine

1977 • 48 citations

Affinity-chromatographic purification of S-adenosyl-<scp>l</scp>-homocysteine hydrolase. Some properties of the enzyme from rat liver

1981 • 48 citations

A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC

1973 • 47 citations

Studies on Substrate Specificity of S-Adenosylmethionine: Protein-Carboxyl Methyltransferase from Calf Brain

1980 • 47 citations

Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants.

1981 • 47 citations

Metabolism of S-Adenosyl-L-homocysteine in Vivo by the Rat

1969 • 47 citations

Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Specificity of the S-adenosylhomocysteine binding site

1973 • 45 citations

Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage

1976 • 44 citations

Phospholipids biosynthesis by methylations and choline incorporation: Effect of 3-deazaadenosine

1980 • 42 citations

Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5′-Methylthioadenosine

1980 • 41 citations

Reaction of 5'-deoxyadenosine and related analogs with the 5'-methylthioadenosine cleaving enzyme of sarcoma 180 cells, a possible chemotherapeutic target enzyme

1979 • 40 citations

Sequestration of adenosine in crude extract from mouse liver and other tissues

1979 • 38 citations

S-Adenosyl-l-homocysteine in brain

1977 • 38 citations

DNA methylase inhibition in vitro by N-methyl-N'-nitro-N-nitrosoguanidine.

1980 • 38 citations

Toxicities of adenosine and 2'-deoxyadenosine in l cells treated with inhibitors of adenosine deaminase

1977 • 38 citations

A sensitive isotopic assay method for hydrolase

1976 • 37 citations

Comparison of some physicochemical and kinetic properties of S-Adenosylhomocysteine hydrolase from bovine liver, bovine adrenal cortex and mouse liver

1982 • 37 citations

In Vitro and In Vivo Binding of S-Adenosyl-L-Homocysteine to Membranes from Rat Cerebral Cortex

1981 • 36 citations

Enzymatic dna methylation in higher eukaryotes

1980 • 36 citations

Cordycepin and xylosyladenine: Inhibitors of methylation of nuclear RNA

1978 • 36 citations

Binding proteins for adenosine 3′:5′-cyclic monophosphate in bovine adrenal cortex

1977 • 35 citations

Inhibition of indolethylamine-N-methyltransferase by analogs of S-adenosylhomocysteine

1975 • 35 citations

5'-Methylthioadenosine Phosphorylase from Caldariella acidophila. Purification and Properties

1979 • 35 citations

Polymer Synthesis in Killed Bacteria: Lethality of 2′,3′-Dideoxyadenosine

1966 • 34 citations

Species and tissue differences in the catabolism of S-adenosyl-L-homocysteine: A quantitative, chromatographic study

1977 • 33 citations

Protein methylation in animal cells II. Inhibition of N-methyltransferase by analogs of

1978 • 33 citations

Mechanism of inhibition of deoxyribonucleic acid synthesis by 1-.beta.-D-arabinofuranosyladenosine triphosphate and its potentiation by 6-mercaptopurine ribonucleoside 5'-monophosphate

1980 • 33 citations

The effect of on DNA methylation in isolated rat liver nuclei

1977 • 32 citations

Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.

1979 • 32 citations

Phosphatidylethanolamine methylation in membranes from rat cerebral cortex: Effect of exogenous phospholipids and S-adenosylhomocysteine

1981 • 32 citations

Metabolism of S-adenosylhomocysteine and S-tubercidinylhomocysteine in neuroblastoma cells

1979 • 32 citations

Partial Purification and Characterization of S -Adenosylhomocysteine Hydrolase Isolated from Saccharomyces cerevisiae

1972 • 31 citations

Reversal of adenine toxicity by pyrimidine nucleosides

1961 • 29 citations

Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.

1980 • 28 citations

Inhibition of mitogen induced blastogenesis by 5′-deoxy-5′-S-iso-butyl adenosine

1976 • 26 citations

Ligand binding to the adenine analog binding protein of the rabbit erythrocyte

1978 • 25 citations

Phospholipid methylation and human platelet function

1981 • 25 citations

Cyclic AMP-adenosine binding protein/S-adenosylhomocysteinase from mouse liver

1979 • 24 citations

Inhibition of platelet phospholipid methylation during platelet secretion

1981 • 24 citations

Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients.

1981 • 23 citations

Some inhibitory effects of 9-beta-D-xylofuranosyladenine, an adenosine analog, on nucleotide metabolism in ascites tumor cells.

1965 • 23 citations

Cytoplasmic location of undermethylated messenger RNA in Novikoff cells

1979 • 22 citations

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.

1982 • 22 citations

Evidence against a requirement for phospholipid methylation in adenylate cyclase activation by hormones

1982 • 22 citations

Metabolic formation of nucleoside-modified analogues of S-adenosylmethionine

1979 • 22 citations

Activation by S-adenosylhomocysteine of norepinephrine and serotonin in vitro uptake in synaptosomal preparations from rat brain

1979 • 21 citations

Enhancement of depolarization-dependent release of norepinephrine by an inhibitor of S-adenosylmethionine-dependent transmethylations

1980 • 21 citations

On the methylation of inorganic mercury and the decomposition of organo-mercury compounds - a review.

1976 • 20 citations

Inhibition oftRNA methylation in vitro and in whole cells by an oncostatic S-adenosyl-homocysteme (SAIl) analogue: 5′ deoxy 5′ -S-isobutyl adenosine (SIBA)

1978 • 19 citations

Recent developments in suicide substrates and other active site-directed inactivating agents of specific target enzymes.

1977 • 19 citations

Inhibition of phospholipid methyltransferase(s) from rat liver plasma membranes by analogues of S-adenosylhomocysteine.

1981 • 19 citations

S-adenosylhomocysteinase from mouse liver. Catalytic properties at cellular enzyme level.

1980 • 18 citations

An Adenosine 3′:5′‐Monophosphate/Adenosine Binding Protein from Mouse Liver

1978 • 18 citations

A study on the sequestration of adenosine and its conversion to adenine by the cyclic AMP-adenosine binding proteins/S-adenosylhomocysteinase from mouse liver

1979 • 18 citations

S-adenosylhomocysteinase from mouse liver. Inactivation of the enzyme in the presence of metabolites

1982 • 17 citations

Interaction of S-adenosylhomocysteine with isolated rat hepatocytes.

1981 • 17 citations

Effect of S-adenosylhomocysteine and S-tubercidinylhomocysteine on transfer ribonucleic acid methylation in phytohemagglutinin-stimulated lymphocytes.

1975 • 17 citations

Purification de la S-adénosyl-L-homocystéine hydrolase du foie de rat par chromatographie d'affinité

1979 • 17 citations

S‐Adenosylhomocysteine hydrolase in human and rat liver is localized to the cytosol fraction of the tissue homogenate

1979 • 17 citations

DNA methylase activity associated with rous sarcoma virus

1978 • 16 citations

THE SYNTHESIS OF CREATINE BY PREPARATIONS OF LIVER FROM EMBRYOS AND ADULTS OF VARIOUS SPECIES

1951 • 16 citations

Methylation of transfer RNA during transformation of human lymphocytes by phytohemagglutinin

1973 • 16 citations

S-adenosylhomocysteine hydrolases as the primary target enzymes in androgen regulation of methylation complexes

1981 • 15 citations

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine

1978 • 15 citations

Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.

1980 • 14 citations

Methionine metabolism in mammals: S-adenosylhomocysteine hydrolase in rat intestinal mucosa

1975 • 14 citations

S-adenosylhomocysteine analogues as inhibitors of specific tRNA methylation

1978 • 14 citations

S-Adenosylhomocysteinase from yellow lupine seeds: stoichiometry and reactions of the enzyme.cntdot.adenosine complex

1981 • 13 citations

The relation between the functions of 9-beta-D-arabinofuranosyladenine as inactivator and substrate of S-adenosylhomocysteine hydrolase.

1981 • 13 citations

Characterization of S-adenosylhomocysteine binding to isolated rat hepatocytes and purified rat liver plasma membranes. Effect of analogues of S-adenosylhomocysteine.

1982 • 12 citations

Cyclic AMP binding protein from Jerusalem artichoke rhizome tissues

1979 • 12 citations

A sensitive radiochemical enzyme assay for S-adenosyl-l-homocysteine and l-homocysteine

1981 • 12 citations

Specific Adenosine Binding Proteins from Rat Liver

1975 • 12 citations

Novel Aspects in the Biochemistry of Adenosylmethionine and Related Sulfur Compounds

1979 • 11 citations

Comparative effect of S‐adenosyl‐homocysteine (SAH) and sinefungin on tRNA‐Base methylation in whole cells and in vitro

1981 • 11 citations

Adenosine 3′,5′-Cyclic Monophosphate-Binding Proteins from Trypanosoma gambiense

1978 • 10 citations

Inactivation of S-adenosylhomocysteine hydrolase: Mechanism and occurrence in vivo in disorders of purine nucleoside catabolism

1982 • 10 citations

New Synthetic S-Adenosylhomocysteine Analogues with Oncostatic and Antiviral Activity

1978 • 9 citations

The hypotensive action of 3-deaza-adenosine

1980 • 9 citations

Action of S-adenosyl-L-homocysteine on the metabolism of dopamine, norepinephrine and serotonin in rat brain.

1979 • 8 citations

Sequential metabolism of 5′-isobutylthioadenosine by methylthioadenosine phosphorylase and purine-nucleoside phosphorylase in viable human cells

1982 • 8 citations

Protein Methylation: Perspectives in Central Nervous System

1979 • 6 citations

Inhibition of methylation of nuclear ribonucleic acid in L1210 cells by tubercidin, 8-azaadenosine and formycin

1980 • 6 citations

S‐Adenosylhomocysteine hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase deficiency disease

1981 • 6 citations

Photoaffinity labeling of three renal cyclic 3′,5′-adenosine monophosphate-binding proteins

1979 • 4 citations

Hypermethylation in the MSO-epileptogenic brain: Reversal by dilantin or phenobarbital

1982 • 4 citations

Analysis and Distribution of Adenosylmethionine and Adenosylhomocysteine in Mammalian Tissues

1979 • 4 citations

Metabolism of 5'deoxy-5'[35S]-isobutyl-thio-adenosine (SIBA) in rats and mice

1980 • 3 citations

Regulatory aspects of S-adenosylmethionine in the periphery and CNS

1982 • 3 citations

Selection of mutant murine lymphoid cells partially deficient in S-adenosylhomocysteine hydrolase

1982 • 2 citations

Concerning the nonspecificity of methylation inhibitors

1982 • 2 citations