S -Adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells

1974 • 1,474 citations

The Enzymatic Synthesis of S-Adenosyl-l-homocysteine from Adenosine and Homocysteine

1959 • 546 citations

The Occurrence of iε-N-Methyl Lysine in Histones

1964 • 472 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

The Specificity of S-Adenosylmethionine Derivatives in Methyl Transfer Reactions

1969 • 281 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase

1973 • 271 citations

Competing Methyltransferase Systems

1972 • 270 citations

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

1977 • 267 citations

Adenosine Inhibition of Lymphocyte-Mediated Cytolysis: Possible Role of Cyclic Adenosine Monophosphate

1975 • 265 citations

Combined immunodeficiency disease associated with adenosine deaminase deficiency

1975 • 255 citations

Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis

1973 • 248 citations

Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.

1978 • 221 citations

The occurrence and distribution of thymine and three methylated-adenine bases in ribonucleic acids from several sources

1958 • 217 citations

Studies on a Possible Regulatory Mechanism for the Biosynthesis of Deoxyribonucleic Acid

1961 • 206 citations

The methylated nucleotide sequences in HeLa cell ribosomal RNA and its precursors

1974 • 171 citations

The effects of methionine deprivation on ribosome synthesis in HeLa cells.

1967 • 170 citations

Rapid Stimulation of protein carboxymethylation in leukocytes by a chemotactic peptide

1978 • 170 citations

Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis.

1978 • 169 citations

DNA methylation in adenovirus, adenovirus-transformed cells, and host cells.

1976 • 155 citations

Purification and Properties of Protein Methylase II

1970 • 155 citations

REGIONAL AND SUBCELLULAR DISTRIBUTION OF PROTEIN CARBOXYMETHYLASE IN BRAIN AND OTHER TISSUES

1976 • 149 citations

Characterization of a cell culture model for the study of adenosine deaminase- and purine nucleoside phosphorylase-deficient immunologic disease

1976 • 143 citations

The Enzymatic Methylation of Ribonucleic Acid and Deoxyribonucleic Acid

1964 • 131 citations

A ROLE FOR PURINE METABOLISM IN THE IMMUNE RESPONSE: ADENOSINE-DEAMINASE ACTIVITY AND DEOXYADENOSINE CATABOLISM

1978 • 121 citations

The kinetics of DNA methylation in cultures of a mouse adrenal cell line

1970 • 112 citations

Adenine and Adenosine Are Toxic to Human Lymphoblast Mutants Defective in Purine Salvage Enzymes

1977 • 112 citations

Studies on the Origin of ε-N-Methyl-l-lysine in Protein

1965 • 107 citations

Analysis of the Methylation Sites in Yeast Ribosomal RNA

1973 • 106 citations

Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling.

1976 • 103 citations

Analysis of adenosine-mediated pyrimidine starvation using cultured wild-type and mutant mouse T-lymphoma cells

1978 • 86 citations

Gene expression in synchronized lymphocytes: Studies on the control of synthesis of immunoglobulin polypeptides

1971 • 84 citations

Nuclear metabolism of ribosomal RNA in growing, methionine-limited, and ethionine-treated HeLa cells

1977 • 82 citations

On the effect of some adenine derivatives on the incorporation in vitro of isotopically labelled compounds into the nucleic acids of ehrlich ascites tumor cells

1959 • 81 citations

Methylation of Protein by Calf Spleen Methylase

1969 • 80 citations

Methylation of sindbis virus “26S” messenger RNA

1975 • 79 citations

Deficiency of adenosine deaminase not associated with severe combined immunodeficiency

1976 • 76 citations

Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

1977 • 74 citations

5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine.

1977 • 73 citations

Transformation and Deoxyribonucleic Acid Size: Extent of Degradation on Entry Varies with Size of Donor

1972 • 66 citations

Importance of initiation factor preparations in the translation of reovirus and globin mRNAs lacking a 5'-terminal 7-methylguanosine

1977 • 64 citations

S-Adenosylhomocysteine inhibition of three purified tRNA methyltransferases from rat liver

1975 • 58 citations

Cytotoxic and metabolic effects of adenosine and adenine on human lymphoblasts.

1978 • 55 citations

Studies on inhibitors of mammalian tRNA methylases

1971 • 55 citations

Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine

1977 • 48 citations

Further characterization of the WI-L1 and WI-L2 lymphoblastoid lines.

1971 • 40 citations

The isolation of 5-methylcytidine from RNA

1960 • 35 citations

The tRNA Methyltransferases

1972 • 32 citations

Purification of S-adenosylmethionine: epsilon-N-L-lysine methyltransferase. The first enzyme in carnitine biosynthesis.

1977 • 27 citations

Etude de l'inhibition d'une t-ARN N2-guanine méthyl transférase de foie de lapin par des analogues de la S-adénosyl homocystéine

1972 • 26 citations

Wasting of 18 S ribosomal RNA by human myeloma cells cultured in adenosine

1976 • 19 citations

Modified bases and transfer RNA function.

1971 • 12 citations

Purine Toxicity in Human Lymphoblasts

1977 • 10 citations