Clinical implications of multidrug resistance to chemotherapy

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

The Pharmacological Basis of Therapeutics

1966 • 539 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer.

1989 • 467 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

1989 • 347 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

1986 • 231 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1988 • 196 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Chronic daily administration of oral etoposide--a phase I trial.

1989 • 153 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.

1989 • 132 citations

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

1989 • 128 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Calmodulin: a potential target for cancer chemotherapeutic agents.

1986 • 124 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

MEDICAL ONCOLOGY

1977 • 116 citations

Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.

1987 • 116 citations

Expression of a human multidrug resistance gene in ovarian carcinomas.

1989 • 115 citations

Multidrug Resistance: Molecular Biology Clinical Relevance

1989 • 114 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

The historical development, cellular electrophysiology and pharmacology of amiodarone

1989 • 114 citations

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

1988 • 110 citations

Quantitative Determination of Factors Contributing to Doxorubicin Resistance in Multidrug-Resistant Cells

1989 • 102 citations

Reversal of drug‐resistance in multiple myeloma with verapamil

1988 • 102 citations

Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines

1986 • 100 citations

Toremifene: pharmacologic and pharmacokinetic basis of reversing multidrug resistance.

1989 • 92 citations

Multidrug resistance in ovarian cancer

1987 • 89 citations

Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification.

1989 • 86 citations

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1988 • 76 citations

Pharmacokinetics and metabolism of bepridil

1985 • 72 citations

Resistance mechanisms in three human small cell lung cancer cell lines established from one patient during clinical follow-up

1990 • 71 citations

Amiodarone-induced enhancement of doxorubicin and 4'-deoxydoxorubicin cytotoxicity to rat colon cancer cells in vitro and in vivo.

1986 • 66 citations

The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells.

1988 • 66 citations

Epidermal growth factor-induced topoisomerase(s)

1983 • 64 citations

Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin‐sensitive and ‐resistant small‐cell lung cancer cell lines, and on cytotoxicity in the tumor cell lines

1987 • 62 citations

Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein

1988 • 58 citations

Comparison of the synergistic potentiation of etoposide, doxorubicin, and vinblastine cytotoxicity by dipyridamole.

1989 • 53 citations

Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs.

1988 • 47 citations

Phase I clinical trial of a combination of dipyridamole and acivicin based upon inhibition of nucleoside salvage.

1988 • 44 citations

The multidrug resistant phenotype in clinical practice; evaluation of cross resistance to ifosfamide and mesna after VP16–213, doxorubicin and vincristine (VPAV) for small cell lung cancer

1988 • 44 citations

Reversal of multidrug resistance by synthetic isoprenoids in the KB human cancer cell line.

1986 • 44 citations

Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and-sensitive cell lines

1987 • 40 citations

Effects of verapamil on the cellular accumulation of daunorubicin in blast cells and on the chemosensitivity of leukaemic blast progenitors in acute myelogenous leukaemia

1989 • 40 citations

Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem

1985 • 39 citations

Methotrexate and dipyridamole combination chemotherapy based upon inhibition of nucleoside salvage in humans.

1989 • 36 citations

Mitomycin C resistant L1210 leukemia cells: Association with pleiotropic drug resistance

1987 • 36 citations

Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.

1988 • 35 citations

Effect of calcium channel blockers on human CFU-GM with cytotoxic drugs.

1987 • 35 citations

Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells

1987 • 34 citations

Issues for the future development of fludarabine phosphate.

1990 • 32 citations

In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.

1988 • 28 citations

Decreased phorbol ester receptor and protein kinase C in P388 murine leukemic cells resistant to etoposide.

1987 • 23 citations

Effect of verapamil on doxorubicin activity and pharmacokinetics in mice bearing resistant and sensitive solid tumors

1988 • 20 citations

Reversal of cancer chemotherapeutic resistance by amphotericin B—A broad phase I–II pilot study

1987 • 16 citations

Pharmacokinetics of intraperitoneally administered dipyridamole in cancer patients.

1988 • 15 citations