Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro

1989 • 1,119 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells

1988 • 786 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

After Insulin Binds

1987 • 687 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Structure of the Receptor for Insulin-Like Growth Factor II: The Puzzle Amplified

1988 • 206 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.

1988 • 199 citations

Histochemical localization of IGF-I and -II mRNA in the developing rat embryo

1987 • 193 citations

Oncogenes and growth control

1985 • 180 citations

The role of glucose and pyruvate transport in regulating nutrient utilization by preimplantation mouse embryos

1988 • 166 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

1975 • 151 citations

INSULIN STIMULATES PROTEIN SYNTHESIS IN COMPACTED MOUSE EMBRYOS

1988 • 145 citations

Insulin as a growth factor in rat hepatoma cells. Stimulation of proto-oncogene expression.

1987 • 143 citations

Preimplantation mouse embryos internalize maternal insulin via receptor-mediated endocytosis: Pattern of uptake and functional correlations

1989 • 139 citations

Insulin increases the cell number of the inner cell mass and stimulates morphological development of mouse blastocysts in vitro

1990 • 133 citations

Glucose Inhibits Development of Hamster 8-Cell Embryos in Vitro1

1989 • 120 citations

Ontogeny of Receptors for Insulin-Like Peptides in Chick Embryo Tissues: Early Dominance of Insulin-Like Growth Factor over Insulin Receptors in Brain*

1985 • 116 citations

Insulin and Glucose-dependent Regulation of the Glucose Transport System in the Rat L6 Skeletal Muscle Cell Line

1989 • 110 citations

Regulation of Glucose-Transporter Function

1990 • 99 citations

Autoradiographic Evidence for Insulin and Insulin-Like Growth Factor Binding to Early Mouse Embryos

1988 • 91 citations

Temporally regulated expression of insulin and insulin‐like growth factors and their receptors in early mammalian development

1989 • 85 citations

Physiological Aspects of Growth and Development of the Preimplantation Mammalian Embryo

1976 • 80 citations

Expression of genes for insulin and insulin‐like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells

1990 • 77 citations

The regulation by insulin of glucose transporter gene expression in 3T3 adipocytes

1989 • 74 citations

Heterogeneity of insulin-like growth factor-I affinity for the insulin-like growth factor-II receptor: Comparison of natural, synthetic and recombinant DNA-derived insulin-like growth factor-I

1987 • 64 citations

Functional foles of insulin and insulinlike growth factors in preimplantation mouse embryo development

1990 • 59 citations

Immunological demonstration of the accumulation of insulin, but not insulin receptors, in nuclei of insulin-treated cells.

1989 • 58 citations

Autoradiographic evidence for insulin and insulin-like growth factor binding to early mouse embryos

1988 • 53 citations

Stage-specific insulin binding in mouse preimplantation embryos

1986 • 53 citations

Developmentally regulated expression of insulin-like growth factors by differentiated murine teratocarcinomas and extraembryonic mesoderm

1986 • 49 citations

Growth Factors in Mammalian Development

2021 • 44 citations

Expression of growth factors during the differentiation of embryonic stem cells in monolayer

1990 • 44 citations

Polymorphic Human Insulin-Responsive Glucose-Transporter Gene on Chromosome 17p13

1989 • 41 citations

Production of insulin‐like growth factor‐II (MSA) by endoderm‐like cells derived from embryonal carcinoma cells: Possible mediator of embryonic cell growth

1985 • 39 citations

Hexose transport in preimplantation rabbit blastocysts

1990 • 38 citations

Receptors for insulin-like growth factors I and II in developing embryonic mouse limb bud

1987 • 32 citations

Early Development and Tissue-Specific Patterns of Insulin Binding in Chick Embryo*

1984 • 29 citations

Rat hepatoma cell variants resistant to insulin-diphtheria toxin A fragment conjugates. Genetic evidence for the separate pathways for insulin receptor-mediated mitogenic and hormonal stimulation.

1986 • 21 citations

5 The Insulin Family of Peptides in Early Mammalian Development

1990 • 19 citations

Intestinal Permeability of Water-Soluble Nonelectrolytes: Sugars, Amino Acids, Peptides

1984 • 16 citations

Metabolism of Glucose by Preimplantation Mouse Embryos in the Presence of Glucagon, Insulin, Epinephrine, cAMP, Theophylline and Caffeine

1985 • 15 citations

The Expression of Growth Factors and Growth Factor Receptors During Mouse Embryogenesis

1986 • 15 citations

Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13

1989 • 11 citations

SOCIETY FOR THE STUDY OF FERTILITY

1961 • 5 citations

Deleted Work

1955 • 0 citations