Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Cancer Cell Cycles

1996 • 5,379 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Tumor Suppressor Genes

1991 • 1,784 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.

1996 • 907 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Leukemia and lymphoma in ataxia telangiectasia

1996 • 619 citations

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1995 • 530 citations

Cell Cycle Control of DNA Replication

1996 • 512 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Four-Agent Induction and Intensive Asparaginase Therapy for Treatment of Childhood Acute Lymphoblastic Leukemia

1986 • 432 citations

Residential Exposure to Magnetic Fields and Acute Lymphoblastic Leukemia in Children

1997 • 419 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia

1975 • 393 citations

EVIDENCE FOR AN INFECTIVE CAUSE OF CHILDHOOD LEUKAEMIA: COMPARISON OF A SCOTTISH NEW TOWN WITH NUCLEAR REPROCESSING SITES IN BRITAIN

1988 • 393 citations

Lineage infidelity in acute leukemia

1983 • 391 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia

1984 • 365 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.

1991 • 360 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif

1989 • 358 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 354 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase Activity

1990 • 301 citations

Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

1989 • 285 citations

Die Corticosteroid-abhängige Dezimierung der Leukämiezellzahl im Blut als Prognosefaktor bei der akuten lymphoblastischen Leukämie im Kindesalter (Therapiestudie ALL-BFM 83)

1987 • 266 citations

TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).

1991 • 265 citations

Hox11 controls the genesis of the spleen

1994 • 261 citations

Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia

1985 • 259 citations

Hierarchical Control of Lymphocyte Survival

1996 • 255 citations

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

1991 • 252 citations

The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.

1988 • 236 citations

The t(11;14)(p15;q11) in a T-Cell Acute Lymphoblastic Leukemia Cell Line Activates Multiple Transcripts, Including Ttg-1, a Gene Encoding a Potential Zinc Finger Protein

1989 • 234 citations

Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study experience.

1996 • 233 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

1989 • 227 citations

Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.

1995 • 217 citations

Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01.

1994 • 210 citations

Acute lymphoblastic leukemia: recent advances in biology and therapy [see comments]

1989 • 203 citations

Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia

1995 • 199 citations

Clinical Importance of Myeloid-Antigen Expression in Acute Lymphoblastic Leukemia of Childhood

1991 • 191 citations

A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)

1991 • 186 citations

Improved disease-free survival of children with acute lymphoblastic leukemia at high risk for early relapse with the New York regimen--a new intensive therapy protocol: a report from the Childrens Cancer Study Group.

1986 • 178 citations

High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasia

1980 • 173 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia

1990 • 168 citations

Lymphoblastic Leukemia with Lymphomatous Features Associated with Abnormalities of the Short Arm of Chromosome 9

1985 • 159 citations

Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.

1996 • 155 citations

Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia

1986 • 151 citations

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

1997 • 150 citations

Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia

1989 • 149 citations

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

1994 • 140 citations

Involvement of the putative hematopoietic transcription factor SCL in T- cell acute lymphoblastic leukemia

1992 • 140 citations

Locus of the α-Chain of the T-Cell Receptor Is Split by Chromosome Translocation in T-Cell Leukemias

1985 • 140 citations

Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

1986 • 136 citations

Cytogenetics of childhood T-cell leukemia

1988 • 135 citations

Myeloid-associated antigen expression lacks prognostic value in childhood acute lymphoblastic leukemia treated with intensive multiagent chemotherapy

1990 • 133 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.

1993 • 130 citations

Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 126 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study

1993 • 118 citations

Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study

1988 • 118 citations

Expression of TAL-1 proteins in human tissues

1995 • 116 citations

INTENSIVE THERAPY FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA AND UNFAVOURABLE PRESENTING FEATURES

1988 • 116 citations

CHILDHOOD LEUKEMIA AND PARENTAL OCCUPATION

1985 • 115 citations

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features

1995 • 114 citations

Clinical Features and Treatment Outcome of Children With Myeloid Antigen Positive Acute Lymphoblastic Leukemia: A Report From the Children's Cancer Group

1997 • 111 citations

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

1994 • 110 citations

Molecular analysis of a t(7;14)(g35;g32) chromosome translocation in a T cell leukemia of a patient with ataxia telangiectasia

1988 • 106 citations

Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study.

1997 • 104 citations

Induction of sister-chromatid exchanges in fish exposed to Rhine water

1980 • 100 citations

Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia.

1991 • 99 citations

The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 99 citations

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

1993 • 94 citations

Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood

1990 • 92 citations

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

1990 • 90 citations

A new translocation, t(10;14)(q24;q11), in T cell neoplasia

1986 • 89 citations

Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia

1995 • 89 citations

Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations

1989 • 89 citations

2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.

1995 • 88 citations

Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers.

1993 • 87 citations

Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

1997 • 81 citations

Cellular Expression of Antiapoptotic BCL-2 Oncoprotein in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia: A Children's Cancer Group Study

1997 • 77 citations

Modified BFM Therapy for Children with Previously Untreated Acute Lymphoblastic Leukemia and Unfavorable Prognostic Features

1988 • 76 citations

Clinical and biologic features predict poor prognosis in acute lymphoid leukemias in children and adolescents: A pediatric oncology group review

1986 • 76 citations

Glucocorticoid receptors in childhood acute lymphocytic leukemia.

1982 • 75 citations

Immunophenotype-karyotype associations in human acute lymphoblastic leukemia

1989 • 73 citations

Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.

1995 • 72 citations

Ataxia-telangiectasia and acute lymphoblastic leukemia

1980 • 69 citations

Improved Clinical Outcome for Children with T-Lineage Acute Lymphoblastic Leukemia After Contemporary Chemotherapy:A Children's Cancer Group Study

1996 • 68 citations

Chromosomal translocation involving the beta T cell receptor gene in acute leukemia.

1988 • 66 citations

Modified LSA2-L2 treatment in 53 children with E-rosette-positive T- cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study)

1982 • 66 citations

Glucocorticoid receptors in immunological subtypes of childhood acute lymphocytic leukemia cells: a Pediatric Oncology Group Study.

1985 • 64 citations

Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A pediatric oncology group study

1990 • 63 citations

Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation.

1989 • 63 citations

T- and b-lymphocytes and lymphoblasts in untreated acute lymphocytic leukemia

1974 • 63 citations

The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

1990 • 61 citations

p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia

1995 • 61 citations

Space-time clustering of childhood leukaemia in Greece: evidence supporting a viral aetiology

1996 • 61 citations

Viruses, clusters and clustering of childhood leukaemia: a new perspective?

1993 • 60 citations

Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts.

1985 • 57 citations

7q32-q36 translocations in childhood T cell leukemia: cytogenetic evidence for involvement of the T cell receptor beta-chain gene

1987 • 53 citations

Significance of aberrant immunophenotypes in childhood acute lymphoid leukemia

1991 • 52 citations

HOX11 expression in pediatric acute lymphoblastic leukemia is associated with T-cell phenotype.

1995 • 51 citations

Space-time clustering of childhood acute lymphoblastic leukaemia: indirect evidence for a transmissible agent

1992 • 49 citations

Specific cytotoxicity of arabinosylguanine toward cultured T lymphoblasts.

1984 • 47 citations

Clinical and Cell Biological Features Related to Cellular Drug Resistance of Childhood Acute Lymphoblastic Leukemia Cells

1995 • 45 citations

Inhibition by quercetin and luteolin of chromosomal alterations induced by salted, deep-fried fish and mutton in rats

1996 • 45 citations

Sequence analysis of the MYC oncogene involved in the t(8;14)(q24;q11) chromosome translocation in a human leukemia T-cell line indicates that putative regulatory regions are not altered.

1988 • 45 citations

Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia.

1993 • 45 citations

Teniposide plus cytarabine improves outcome in childhood acute lymphoblastic leukemia presenting with a leukocyte count greater than or equal to 100 x 10(9)/L.

1987 • 45 citations

Comparison of outcome, clinical, laboratory, and immunological features in 164 children and adults with T-ALL. The Groupe d'Etude Immunologique des Leucémies.

1990 • 43 citations

The LCK Gene Is Involved in the t(1;7)(p34;q34) in the T‐Cell Acute Lymphoblastic Leukemia Derived Cell Line, HSB‐2

1991 • 41 citations

ADA and PNP Deficiencies: How It All Began

1985 • 38 citations

A study of chromosome 11p13 translocations involving TCR beta and TCR delta in human T cell leukaemia.

1991 • 38 citations

Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia A pediatric oncology group study

1987 • 38 citations

CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study

1996 • 37 citations

Clinical relevance of in vitro drug resistance testing in childhood acute lymphoblastic leukemia: The state of the art

1994 • 36 citations

Clinical and biologic features of childhood T-cell leukemia with the t(11;14)

1991 • 34 citations

Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript.

1988 • 34 citations

In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin.

1997 • 34 citations

The role of intracellular signalling pathways regulating thymocyte and leukemic T cell apoptosis.

1996 • 33 citations

The chromosome translocation (11;14)(p13;q11) associated with T cell acute leukemia. Asymmetric diversification of the translocational junctions.

1990 • 33 citations

Two forms of Hox11, a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes

1995 • 31 citations

SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line.

1993 • 30 citations

Thymic involvement and initial white blood count in childhood acute lymphoblastic leukemia.

1981 • 30 citations

APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.

1994 • 29 citations

Breakage of the T cell receptor ? chain locus in non malignant clones from patients with ataxia telangiectasia

1988 • 27 citations

Immunotoxins for Treatment of Leukemia and Lymphoma

1995 • 25 citations

Clinicopathologic aspects of E rosette negative T cell acute lymphocytic leukemia: a Pediatric Oncology Group study.

1986 • 23 citations

PHARMACOLOGIC PURGING OF MALIGNANT T CELLS FROM HUMAN BONE MARROW USING 9-β-D-ARABINOFURANOSYLGUANINE

1991 • 22 citations

Role of the p53 tumor suppressor gene in the pathogenesis and in the suppression of acute lymphoblastic T-cell leukemia.

1992 • 21 citations

HTLV and human leukemia: perspectives 1986.

1986 • 20 citations

Anti‐Tac(Fab)‐PE40, a recombinant double‐chain immunotoxin which kills interleukin‐2‐receptor‐bearing cells and induces complete remission in an in vivo tumor model

1994 • 20 citations

Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic leukaemias

1996 • 20 citations

Intensive alternating drug pairs for treatment of high-risk childhood acute lymphoblastic leukemia. A pediatric oncology group pilot study

1993 • 19 citations

Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11

1987 • 19 citations

Relationship of growth hormone deficiency and leukemia

1995 • 18 citations

Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia

1997 • 15 citations

Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies.

1993 • 15 citations

Results of Acute Lymphoblastic Leukemia Therapy in Childhood with a Modified BFM Protocol in a Multicenter Study in the German Democratic Republic

1987 • 14 citations

Normal mutation frequencies of somatic cells in patients receiving growth hormone therapy

1996 • 13 citations

Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.

1993 • 13 citations

Treatment of leukemia patients with T101 ricin A chain immunotoxins

1988 • 13 citations

Peripheral T‐cell lymphoma in childhood: A report of five cases in Taiwan

1994 • 10 citations

Translocation 11;14 in three children with acute lymphoblastic leukemia of T-cell origin

1995 • 10 citations

Molecular cloning of the translocation breakpoint in T-ALL 11;14 (p13;q11): genomic map of TCR alpha and delta region on chromosome 14q11 and long-range map of region 11p13

1989 • 10 citations

Intermediate-Risk Childhood Acute Lymphoblastic Leukemias: Amsacrine + Cytosine Arabinoside Versus Intermediate-Dose Methotrexate for Consolidation, and 6-Mercaptopurine + Methotrexate + Vincristine Versus Monthly Pulses for Maintenance

1987 • 6 citations