Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Nerve growth factor.

1968 • 2,025 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989 • 429 citations

Reduction of the naturally occurring motor neuron loss by enlargement of the periphery

1976 • 425 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

1979 • 378 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

1990 • 365 citations

The interleukin-2 receptor.

1991 • 354 citations

Regression versus peripheral control of differentiation in motor hypoplasia

1958 • 350 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Sensory neurons in culture: Changing requirements for survival factors during embryonic development

1980 • 302 citations

Human platelets contain brain-derived neurotrophic factor

1990 • 288 citations

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

1990 • 278 citations

Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons

1975 • 277 citations

Neurotrophic molecules

1989 • 270 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Body and brain: A trophic theory of neural connections

1989 • 259 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section

1989 • 253 citations

The response of chick sensory neurons to brain-derived neurotrophic factor

1986 • 251 citations

Ultrastructural features of six types of neurons in rat dorsal root ganglia

1983 • 242 citations

Nerve growth factor prevents toxic neuropathy in mice

1991 • 236 citations

The role of NGF in sensory neurons in vivo

1986 • 233 citations

Glia-Induced Morphological Differentiation in Neuroblastoma Cells

1973 • 228 citations

Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study

1975 • 221 citations

Neuropeptide expression in cultures of adult sensory neurons: Modulation of substance P and calcitonin gene-related peptide levels by nerve growth factor

1989 • 221 citations

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

1979 • 220 citations

Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin

1988 • 218 citations

Survival and Axonal Elongation of Adult Rat Retinal Ganglion Cells

1989 • 210 citations

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

1980 • 210 citations

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

1988 • 208 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications

1989 • 194 citations

The Neurotrophins BDNF, NT‐3 and NT‐4/5, But Not NGF, Up‐regulate the Cholinergic Phenotype of Developing Motor Neurons

1993 • 192 citations

New Neurotrophic Factors

1983 • 190 citations

Second symposium on catecholamines. Modification of sympathetic function. Immunosympathectomy.

1966 • 188 citations

In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

1987 • 187 citations

Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.

1981 • 180 citations

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

1990 • 170 citations

New factor released by cultured glioma cells supporting survival and growth of sensory neurones

1978 • 167 citations

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

1982 • 163 citations

Different factors from the central nervous system and periphery regulate the survival of sensory neurones

1986 • 159 citations

The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age

1989 • 154 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

Interactions between neurons and their targets during in vivo synaptogenesis.

1978 • 152 citations

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

1984 • 152 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Nerve Growth Factor Regulates Expression of the Nerve Growth Factor Receptor Gene in Adult Sensory Neurons

1990 • 136 citations

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF)

1988 • 134 citations

Astrocyte cultures from adult rat brain. Derivation, characterization and neurotrophic properties of pure astroglial cells from corpus callosum

1982 • 125 citations

Somatic and behavioural postnatal effects of fetal injections of nerve growth factor antibodies in the rat

1981 • 125 citations

Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery.

1984 • 125 citations

Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival

1985 • 118 citations

Requirement of a neural tube signal for the differentiation of neural crest cells into dorsal root ganglia

1986 • 115 citations

Sciatic nerve transection produces death of dorsal root ganglion cells and reversible loss of substance P in spinal cord

1985 • 113 citations

What, if anything, is a neurotrophic factor?

1988 • 108 citations

The cranial sensory ganglia in culture: Differences in the response of placode-derived and neural crest-derived neurons to nerve growth factor

1985 • 106 citations

Placodal sensory neurons in culture: Nodose ganglion neurons are unresponsive to NGF, lack NGF receptors but are supported by a liver-derived neurotrophic factor

1985 • 101 citations

Neuronal precursor cells in chick dorsal root ganglia: Differentiation and survival in vitro

1988 • 98 citations

The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells.

1987 • 98 citations

Chapter 15 Brain derived neurotrophic factor

1987 • 94 citations

Effects of antibodies to nerve growth factor on intrauterine development of derivatives of cranial neural crest and placode in the guinea pig

1983 • 79 citations

Brain-derived neurotrophic factor stimulates survival and neuronal differentiation in cultured avian neural crest

1988 • 78 citations

Role of neurotrophic factors in development

1988 • 70 citations

Distinction between nerve growth factor and glial factor

1975 • 66 citations

Developmentally regulated induction of neurite outgrowth from immature chick sensory neurons (DRG) by homogenates of avian or mammalian heart, liver and brain

1979 • 66 citations

Extract from brain stimulates neurite outgrowth from fetal rat retinal explants

1982 • 63 citations

Differences and similarities in the neurotrophic growth factor requirements of sensory neurons derived from neural crest and neural placode

1985 • 56 citations

Spinal cord contains neurotrophic activity for spinal nerve sensory neurons. Late developmental appearance of a survival factor distinct from nerve growth factor

1984 • 47 citations

Cellular and molecular biology of neuronal development

1984 • 38 citations

Neural crest-derived spinal and cranial sensory neurones are equally sensitive to NGF but differ in their response to tissue extracts

1984 • 37 citations

Influence of nerve growth factor on developing dorso‐medial and ventro‐lateral neurons of chick and mouse trigeminal ganglia

1983 • 36 citations

Brain‐Derived Neurotrophic Factor Protects Dopaminergic Cells from 6‐Hydroxydopamine Toxicity

1992 • 35 citations

The Role of Cell Interactions in Early Neurogenesis

1984 • 34 citations

Neurotrophic Factors, Their Receptors, and the Signal Transduction Pathways They Activate

1990 • 33 citations

Neuronal growth factors

1983 • 25 citations

Factors Involved in the Regulation of the Survival and Differentiation of Neurons

1982 • 6 citations

Somatosensory Pathways

2006 • 2 citations

Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Peripheral Sensory and Sympathetic Neurons

1984 • 2 citations

Purification of a Neurotrophic Protein from Mammalian Brain

1984 • 1 citations