Ototoxicity of Chemotherapeutic Agents

Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

1965 • 2,890 citations

High dose Cis-platinum diammine dichloride.Amelioration of renal toxicity by mannitol diuresis

1977 • 622 citations

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

1987 • 474 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

Prevention of Cisplatin Neurotoxicity with an ACTH(4–9) Analogue in Patients with Ovarian Cancer

1990 • 287 citations

Cisplatin ototoxicity in children: A practical grading system

1991 • 280 citations

Clinical Pharmacokinetics of Carboplatin

1991 • 247 citations

Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles

1987 • 241 citations

Cisplatin nephrotoxicity

1989 • 232 citations

Nerve growth factor prevents experimental cisplatin neuropathy

1992 • 208 citations

Distribution and disposition of platinum following intravenous administration of cis-diamminedichloroplatinum(II) (NSC 119875) to dogs.

1976 • 205 citations

Uptake and metabolism of cisplatin by rat kidney

1984 • 199 citations

Carboplatin

1989 • 194 citations

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

1988 • 191 citations

Effect of diethyldithiocarbamate on cis-diamminedichloroplatinum(II)-induced cytotoxicity, DNA cross-linking, and gamma-glutamyl transpeptidase inhibition.

1986 • 182 citations

Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin

1984 • 182 citations

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 • 176 citations

Ototoxicity of low- and moderate-dose cisplatin

1985 • 176 citations

Active Head‐Movement Analysis of Cisplatin‐Induced Vestibulotoxicity

1988 • 171 citations

Alterations in the toxicity of cis-Dichlorodiammineplatinum-II and in tissue localization of platinum as a function of NaCl concentration in the vehicle of administration

1981 • 170 citations

Ototoxicity of high‐dose cisplatin by bolus administration in patients with advanced cancers and normal hearing

1988 • 164 citations

Cisplatin Nephrotoxicity

1986 • 164 citations

Ototoxicity of the Anticancer Drug Cisplatin:An Experimental Study

1982 • 163 citations

Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury

1988 • 160 citations

Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate.

1986 • 158 citations

High‐Dose cisplatin treatment: Hearing loss and plasma concentrations

1990 • 150 citations

High-dose cisplatin with sodium thiosulfate protection.

1985 • 148 citations

cis-Platinum Ototoxicity

1978 • 147 citations

Treatment of poor prognosis nonseminomatous testicular cancer with a “high-dose” platinum combination chemotherapy regimen

1983 • 146 citations

Drug-induced Ototoxicity

1980 • 139 citations

Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.

1988 • 139 citations

Ototoxicity of cis-diamminedichloroplatinum (II): Influence of dose, schedule and mode of administration

1983 • 139 citations

Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig

1975 • 138 citations

Hearing loss in children receiving cisplatin chemotherapy

1983 • 136 citations

Clinical trials of cis-diamminedichloroplatinum (NSC-119875).

1973 • 133 citations

The ototoxic mechanism of cisplatin

1990 • 129 citations

Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase).

1978 • 116 citations

Auditory toxicity effects of long‐term cis‐dichlorodiammineplatinum II therapy in genitourinary cancer patients

1981 • 114 citations

Cis‐Diamminedichloroplatinum (II) Ototoxicity in the Guinea Pig

1981 • 110 citations

Inner ear histopathology in patients treated with Cis‐Platinum.

1982 • 110 citations

Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man.

1974 • 108 citations

Cis‐platinum Ototoxicity: Clinical experience and temporal bone histopathology

1983 • 106 citations

Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats.

1989 • 103 citations

Effect of the aminosteroid U74006F after cardiopulmonary arrest in dogs.

1988 • 100 citations

High Frequency Audiometry in Prospective Clinical Research of Ototoxicity Due to Platinum Derivatives

1988 • 99 citations

Cis‐Platinum ototoxicity in children

1991 • 96 citations

Cis-dichlorodiammineplatinum (II) (NSC-119875): hearing loss and other toxic effects in rhesus monkeys.

1975 • 95 citations

Changes in the stria vascularis of the guinea pig due to cis-platinum

1984 • 95 citations

The ototoxic effect of cisplatin on guinea pigs in relation to dosage

1989 • 92 citations

Interaction of cisplatin and noise on the peripheral auditory system

1990 • 86 citations

Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs

1988 • 82 citations

Cisplatin: Evaluation of its ototoxic potential

1986 • 80 citations

Zinc and the Special Senses

1983 • 78 citations

Drug Ototoxicity

1986 • 78 citations

Degeneration of the Organ of Corti Following Intravenous Administration of Cisplatin

1991 • 78 citations

The Role of High-Frequency Audiometry in Early Detection of Ototoxicity

1985 • 77 citations

Ototoxicity Due to Cis-diamminedichloro-platinum in the Treatment of Ovarian Cancer

1991 • 76 citations

Subcellular localization of cis-dichlorodiammineplatinum(II) in rat kidney and liver

1980 • 68 citations

Cisplatin ototoxicity in guinea pigs with special reference to toxic effects in the stria vascularis

1988 • 68 citations

Cisplatin rescue therapy: Experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate

1990 • 66 citations

Cis-platinum vestibular toxicity

1981 • 66 citations

Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant

1981 • 65 citations

Cisplatin nephrotoxicity: In vitro studies with precision-cut rabbit renal cortical slices

1987 • 64 citations

High-dose cisplatin in advanced head and neck cancer

1987 • 63 citations

Kinetics of sodium thiosulfate, a cisplatin neutralizer

1984 • 63 citations

Effects of cis-diamminedichloroplatinum(II) on rabbit kidney in vivo and on rabbit renal proximal tubule cells in culture.

1988 • 63 citations

Characteristics and drug responses of cochlear and vestibular adenylate cyclase

1980 • 60 citations

The activity of single-agent carboplatin in advanced seminoma

1992 • 60 citations

Morphological and electrophysiological study of the effects of cisplatin and ORG.2766 on rat spinal ganglion neurons.

1990 • 59 citations

Amelioration of Cisplatin‐Induced ototoxicity by fosfomycin

1986 • 56 citations

Cisplatinum: A review, with special reference to cellular and molecular interactions

1984 • 54 citations

Ototoxicity of Cisplatin vs. Platinum Analogs CBDCA (JM‐8) and CHIP (JM‐9)

1986 • 53 citations

New Pharmacological Treatment of Acute Spinal Cord Trauma

1988 • 51 citations

Final report on the united states phase i clinical trial of the hypoxic cell radiosensitizer, misonidazole (RO-07-0582; NSC #261037)

1981 • 51 citations

Nephrotoxicity of cisplatin, carboplatin and transplatin

1990 • 50 citations

Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics

1987 • 49 citations

Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).

1984 • 49 citations

Ototoxic and Nephrotoxic Effects of Combined Treatment with cis‐Diamminedichloroplatinum and Kanamycin in the Guinea Pig

1984 • 49 citations

Cis‐platinum ototoxicity in children

1991 • 48 citations

Cisplatin vestibular ototoxicity: preliminary report.

1982 • 44 citations

Acute acoustic nerve palsy associated with vincristine therapy

1981 • 43 citations

Sensorineural hearing loss associated with vincristine treatment

1990 • 42 citations

Putative neurotrophic factors in the protection of cisplatin-induced peripheral neuropathy in rats

1991 • 40 citations

Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma.

1990 • 40 citations

Cisplatin vestibular ototoxicity: Preliminary report.

1982 • 40 citations

The mechanism of interaction between cisplatin and selenite

1991 • 40 citations

Alterations in hepatic and renal levels of glutathione and activities of glutathione S-transferases from rats treated with cis-dichlorodiamminelatinum-II

1982 • 39 citations

Clinical pharmacology of bleomycin and cisplatin

1981 • 39 citations

Toxicity and clinical tolerance of lonidamine.

1991 • 39 citations

Cis-Diaminedichloro Platinum Ototoxicity: An Experimental Study

1985 • 38 citations

Very high-dose cisplatin-induced ototoxicity: a preliminary report on early and long-term effects

1988 • 38 citations

Cisplatin blocks depolarization-induced calcium entry in isolated cochlear outer hair cells

1991 • 37 citations

The cortitoxic effects of cis-platinum in the guinea pig

1982 • 37 citations

Potentiating Effects of Cisplatin and Ethacrynic Acid in Ototoxicity

1981 • 37 citations

Effect of cisplatin on the plasma membrane phosphatase activities in ascites sarcoma-180 cells: a cytochemical study.

1983 • 37 citations

Hyperuricemia and hypoalbuminemia predispose to cisplatin-induced nephrotoxicity

1986 • 35 citations

The influence of ototoxic drugs on brainstem auditory evoked potentials in man

1981 • 34 citations

Intensive anti-oxidant pretreatment retards motor nerve degeneration

1987 • 34 citations

Glucocorticoid preservation of motor nerve function during early degeneration

1977 • 34 citations

Supplemental Fosfomycin and/or Steroids that Reduce Cisplatin-Induced Nephrotoxicity

1988 • 33 citations

Ototoxicity of cis-platinum and its relationship to eye colour

1991 • 32 citations

Factors influencing ototoxicity in ovarian cancer patients treated with Cis-platinum based chemotherapy.

1992 • 31 citations

Cisplatin, ara-C and etoposide (PAE) in the treatment of recurrent childhood brain tumors

1991 • 31 citations

Trace metals and otolith defects in mocha mice

1984 • 31 citations

Correlations between cis-platinum dosage and toxicity in a guinea pig model

1988 • 31 citations

Principles in Cochlear Toxicity

1985 • 31 citations

Dose-Related α-Difluoromethylornithine Ototoxicity

1991 • 31 citations

Mechanisms for the renal secretion of cisplatin.

1984 • 29 citations

Rapid onset hearing loss after Cisplatinum therapy: Case reports and literature review

1982 • 29 citations

Zinc and presbycusis.

1985 • 28 citations

Inhibition of cis-diamminedichloroplatinum (II) ? induced renal toxicity in the rat

1986 • 28 citations

Effects of vincristine, maytansine, and cis‐platinum on behavioral and electrophysiological indices of neurotoxicity in the rat

1984 • 27 citations

Stimulation of the renal endoplasmic reticulum calcium pump: A possible biomarker for platinate toxicity

1988 • 25 citations

Effects of the diuretics mannitol or acetazolamide on nephrotoxicity and physiological disposition of cisplatin in rats

1984 • 25 citations

The Pharmacology of Ototoxic Drugs

1982 • 23 citations

Clinical experience with misonidazole.

1978 • 23 citations

Vestibular morphological analysis of the effects of cisplatin vs. platinum analogs, CBDCA (JM-8) and CHIP (JM-9).

1986 • 22 citations

Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin

1981 • 21 citations

Assessment of cisplatin-induced ototoxicity using derived-band ABRs

1991 • 21 citations

Peripheral neuropathy and ototoxicity of dichlorodiamineplatinum: Instrumental evaluation

1986 • 21 citations

Pharmacokinetic aspects of cerebrospinal fluid penetration of fosfomycin.

1985 • 21 citations

The effect of vincristine on the neurological elements of the rabbit cochlea

1981 • 20 citations

Audiometric test criteria in the detection of cisplatin ototoxicity.

1992 • 20 citations

Phase II trial of high-dose cisplatin with sodium thiosulfate nephroprotection in patients with advanced carcinoma of the uterine cervix previously untreated with chemotherapy

1991 • 19 citations

An Animal Model of Hearing Loss From -Difluoromethylornithine

1989 • 19 citations

Recent developments in the field of phosphonic acid antibiotics

1984 • 18 citations

Clinical pharmacology of carboplatin.

1990 • 17 citations

Quantitative subcellular distribution of platinum in rat tissues following i. v. bolus and i. v. infusion of cisplatin

1990 • 17 citations

The “plateau effect” of cis‐platinum‐induced hearing loss

1991 • 17 citations

Vestibular morphological analysis of the effects of cisplatin VS. platinum analogs, CBDCA (JM‐8)

1986 • 16 citations

Protective Effect of Fosfomycin against Aminoglycoside Ototoxicity

1985 • 15 citations

Differences in the cochlear degeneration pattern in the guinea pig as a result of gentamicin and cis-platinum intoxication

1984 • 15 citations

Assessment of the effect of chemotherapy and radiotherapy on the auditory function of children with cancer

2009 • 15 citations

The effect of vinblastine sulphate on the neurological elements of the rabbit cochlea

1982 • 13 citations

Assessment of the effect of chemotherapy and radiotherapy on the auditory function of children with cancer

1986 • 13 citations

A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix

1982 • 12 citations

Ototoxicity: etiology and issues.

1983 • 11 citations

[Reduction of cisplatin toxicity by fosfomycin in animal models].

1984 • 11 citations

CRC Handbook of Ototoxicity

2019 • 7 citations

Lonidamine in malignant brain tumors.

1991 • 6 citations

[Effect of fosfomycin on auditory organs and its transfer to cochlear lymph following application of its solution into a middle ear cavity].

1985 • 6 citations

Cochleovestibular Toxicity Related to Dichloromethotrexate

1989 • 6 citations

Nature and Incidence of Misonidazole-Produced Ototoxicity

1981 • 6 citations

A phase I study of hepatic arterial infusion using difluoromethylornithine

1989 • 5 citations

Protective Effect of Fosfomycin against Cisplatin-induced Ototoxicity in Rats

1984 • 5 citations

Pharmakokinetik des Fosfomycins und Otitis media

1982 • 4 citations

[Protective effect of fosfomycin on cisplatin-induced ototoxicity in rats].

1984 • 4 citations

[Protective effect of fosfomycin against aminoglycoside induced ototoxicity].

1983 • 3 citations

Untitled

1983 • 3 citations

Platinum and other metal coordination compounds in cancer chemotherapy : proceedings of the Fifth International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, Abano Terme (Padova) Italy, June 29-July 2, 1987

1988 • 2 citations

[Experimental study of the ototoxicity of fosfomycin].

1986 • 2 citations

Organ directed toxicities of anticancer drugs : proceedings of the First International Symposium on the Organ Directed Toxicities of Anticancer Drugs, convened in Burlington, Vermont by the Vermont Regional Cancer Center, June 4-6, 1987

1988 • 2 citations