Cisplatin rescue therapy: Experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate

Intraperitoneal Cisplatin with Systemic Thiosulfate Protection

1982 • 494 citations

Cisplatin neuropathy. Clinical, electrophysiologic, morphologic, and toxicologic studies

1984 • 401 citations

Hypomagnesemia and Renal Magnesium Wasting in Patients Receiving Cisplatin

1979 • 346 citations

High-Dose Cisplatin in Hypertonic Saline

1984 • 335 citations

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

1980 • 300 citations

Renal and Electrolyte Disturbances Associated with Cisplatin

1981 • 297 citations

Platinum Coordination Complexes in Cancer Chemotherapy

1984 • 264 citations

Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles

1987 • 241 citations

Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model.

1979 • 240 citations

High-dose cisplatin in hypertonic saline in refractory ovarian cancer.

1985 • 225 citations

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721

1988 • 217 citations

NITRITE AND THIOSULFATE THERAPY IN CYANIDE POISONING

1952 • 208 citations

WR-2721 and high-dose cisplatin: an active combination in the treatment of metastatic melanoma.

1987 • 197 citations

Intraperitoneal cis-diamminedichloroplatinum with systemic thiosulfate protection.

1983 • 194 citations

Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.

1987 • 190 citations

Metabolism of disulfiram and diethyldithiocarbamate in rats with demonstration of an in vivo ethanol-induced inhibition of the glucuronic acid conjugation of the thiol

1965 • 188 citations

Clinical kinetics of intact cisplatin and some related species

1981 • 185 citations

Effect of diethyldithiocarbamate on cis-diamminedichloroplatinum(II)-induced cytotoxicity, DNA cross-linking, and gamma-glutamyl transpeptidase inhibition.

1986 • 182 citations

Ototoxicity of low- and moderate-dose cisplatin

1985 • 176 citations

Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.

1980 • 171 citations

Alterations in the toxicity of cis-Dichlorodiammineplatinum-II and in tissue localization of platinum as a function of NaCl concentration in the vehicle of administration

1981 • 170 citations

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines

1989 • 168 citations

Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate.

1986 • 158 citations

High-dose cisplatin with sodium thiosulfate protection.

1985 • 148 citations

Selective inhibition of the nephrotoxicity of cis-dichlorodiammineplatinum(II) by WR-2721 without altering its antitumor properties.

1980 • 146 citations

Mechanism of cis-platinum nephrotoxicity: I. Effects of sulfhydryl groups in rat kidneys.

1980 • 139 citations

Creatinine clearance as a predictor of ultrafilterable platinum disposition in cancer patients treated with cisplatin: relationship between peak ultrafilterable platinum plasma levels and nephrotoxicity.

1987 • 138 citations

Radiobiolgoical and biochemical studies of thiophosphate radioprotective compounds related to cysteamine.

1971 • 135 citations

Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin

1986 • 130 citations

Cisplatin hydration with and without mannitol diuresis in refractory disseminated malignant melanoma: a southwest oncology group study.

1982 • 129 citations

Toxicity of WR-2721 administered in single and multiple doses

1984 • 128 citations

WR-2721 protects against the hematologic toxicity of cyclophosphamide: a controlled phase II trial.

1986 • 121 citations

Phase I/II trials of WR-2721 and cis-platinum

1986 • 114 citations

Radiobiological and Biochemical Studies of Thiophosphate Radioprotective Compounds Related to Cysteamine

1971 • 105 citations

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide

1980 • 103 citations

THE RENAL CLEARANCE OF THIOSULFATE WITH OBSERVATIONS ON ITS VOLUME DISTRIBUTION

1946 • 101 citations

Mechanism of cisplatin nephrotoxicity.

1983 • 97 citations

High-dose cisplatin therapy in ovarian cancer.

1985 • 92 citations

High-dose platinum for the treatment of refractory ovarian cancer

1981 • 84 citations

Efficacy of the neuropeptide ORG.2766 in the prevention and treatment of cisplatin-induced neurotoxicity in rats

1988 • 79 citations

Plasma levels and urinary excretion of filterable platinum species following bolus injection and iv infusion of cis-dichlorodiammineplatinum(II) in man.

1978 • 79 citations

Hypomagnesemia After Cisplatin Combination Chemotherapy

1984 • 79 citations

Interaction of cisplatin and carboplatin with sodium thiosulfate: reaction rates and protein binding.

1986 • 78 citations

The inhibition of renal ATPase by cisplatin and some bio-transformation products

1982 • 78 citations

Pharmacokinetics of WR-2721

1988 • 78 citations

Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine.

1979 • 77 citations

Cisplatin Dose Intensity in Non-Small Cell Lung Cancer: Phase II Results of a Day 1 and Day 8 High-Dose Regimen

1989 • 70 citations

Prediction of the Effective Radioprotective Dose of WR-2721 in Humans through an Interspecies Tissue Distribution Study

1976 • 68 citations

Effect of thiourea on survival and DNA cross-link formation in cells treated with platinum(II) complexes, L-phenylalanine mustard, and bis(2-chloroethyl)methylamine.

1979 • 66 citations

Military Radiobiology

1987 • 66 citations

Clinical pharmacology of high-dose cisplatin

1985 • 65 citations

High-dose cisplatin in hypertonic saline: reduced toxicity of a modified dose schedule and correlation with plasma pharmacokinetics. A Northern California Oncology Group Pilot Study in non-small-cell lung cancer.

1986 • 62 citations

Diethyldithiocarbamate in treatment of acute cadmium poisoning.

1981 • 56 citations

Amelioration of Cisplatin‐Induced ototoxicity by fosfomycin

1986 • 56 citations

Prospective randomized trial of high-dose cisplatin and fluorouracil infusion with or without sodium diethyldithiocarbamate in recurrent and/or metastatic squamous cell carcinoma of the head and neck.

1988 • 54 citations

Nephrotoxicity of high-dose intracavitary cisplatin with intravenous thiosulfate protection

1985 • 52 citations

Diethyldithiocarbamate inhibition of murine bone marrow toxicity caused by cis-diamminedichloroplatinum(II) or diammine-(1,1-cyclobutanedicarboxylato)platinum(II).

1988 • 51 citations

Biochemical modulation of cisplatin toxicity

1989 • 47 citations

Phase I trials of WR-2721 and cis-platinum

1984 • 47 citations

Protection by sodium thiosulfate and thiourea against lethal toxicity of cis-diamminedichloroplatinum(II) in bacteria and mice.

1981 • 47 citations

High-dose cisplatin in patients with advanced malignancies

1985 • 46 citations

Efficacy study of intensive cis-platin therapy in advanced non-small cell bronchogenic carcinoma

1982 • 44 citations

Inhibition of cisplatin-induced nephrotoxicity in rats by buthionine sulfoximine, a glutathione synthesis inhibitor

1987 • 44 citations

Protective effect of sodium-2-mercaptoethanesulfonate on the gastrointestinal toxicity and lethality of cis-diamminedichloroplatinum.

1986 • 43 citations

High-Dose Carboplatin With Diethyldithiocarbamate Chemoprotection in Treatment of Women With Relapsed Ovarian Cancer

1988 • 40 citations

Modification of the bone marrow toxicity of cis-diamminedichloroplatinum(II) in mice by diethyldithiocarbamate.

1984 • 39 citations

Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits

1985 • 34 citations

Enhanced therapeutic efficacy of cisplatin by combination with diethyldithiocarbamate and hyperthermia in a mouse model.

1987 • 34 citations

Evaluation of cisplatin dose intensity: current status and future prospects.

1989 • 33 citations

Phase I clinical trials of WR-2721 with alkylating agent chemotherapy

1982 • 28 citations

Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram

1978 • 27 citations

Chemical reactivity of cisplatin bound to human plasma proteins

1987 • 27 citations

Further evaluation of diethyldithiocarbamate as an antagonist of cisplatin toxicity.

1982 • 26 citations

Protection of antiproliferative effect of cis-diamminedichloroplatinum (II) by sodium thiosulfate

1986 • 24 citations

High-dose cisplatin with diethyldithiocarbamate (DDTC) rescue therapy: preliminary pharmacologic observations

1989 • 21 citations

Effective prevention of the nephrotoxicity of cis-platin (CDDP) by administration of sodium 2-mercaptoethane-sulfonate (MESNA) in rats

1985 • 20 citations

Intraperitoneal chemotherapy: the use of concurrent systemic neutralizing agents.

1985 • 19 citations

Drug targeting: Magnetically responsive albumin microspheres—A review of the system to date

1981 • 16 citations

Diethyldithiocarbamate and cis-Platinum Toxicity

1984 • 15 citations

Hypomagnesemia Following High-Dose Intracavitary Cisplatin with Systemically Administered Sodium Thiosulfate

1986 • 13 citations

Hypomagnesemia after cisplatin combination chemotherapy

1984 • 13 citations

Protection against cis-dichlorodiammine pt (II) cytotoxicity in vitro by cysteamine

1982 • 12 citations

Chemical reactions occurring between metal-containing antineoplastic drugs and biological molecules

1988 • 9 citations

A model for ultrafilterable plasma platinum disposition in patients treated with cisplatin

1987 • 7 citations