Carboplatin

Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.

1987 • 498 citations

Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II

1982 • 487 citations

Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function.

1984 • 304 citations

Preclinical studies identifying carboplatin as a viable cisplatin alternative

1985 • 246 citations

Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function.

1984 • 242 citations

Kinetics of cis‐dichlorodiammineplatinum

1979 • 192 citations

Carboplatin and recurrent childhood brain tumors.

1987 • 183 citations

Carboplatin: a very active new cisplatin analog in the treatment of small cell lung cancer.

1985 • 151 citations

High-dose carboplatin in refractory ovarian cancer patients.

1987 • 151 citations

A randomized comparative trial of carboplatin and iproplatin in advanced squamous carcinoma of the uterine cervix: a Gynecologic Oncology Group study.

1989 • 146 citations

A phase I and pharmacokinetic study of diamminecyclobutane-dicarboxylatoplatinum (NSC 241240).

1983 • 144 citations

Phase I studies with carboplatin at the Royal Marsden Hospital

1985 • 133 citations

Carboplatin (NSC-241-240): an active platinum analog for the treatment of squamous-cell carcinoma of the head and neck.

1986 • 122 citations

Phase II study of JM8, a new platinum analog, in advanced ovarian carcinoma.

1983 • 116 citations

Preclinical antitumor and toxicologic profile of carboplatin

1985 • 111 citations

Ovarian trials at the Royal Marsden

1985 • 110 citations

A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cells.

1985 • 106 citations

Preclinical studies on toxicity, antitumour activity and pharmacokinetics of cisplatin and three recently developed derivatives

1984 • 99 citations

Carboplatin (Paraplatin; JM8) and etoposide (VP-16) as first-line combination therapy for small-cell lung cancer.

1987 • 96 citations

Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts.

1985 • 88 citations

Phase I clinical trial and pharmacokinetics of carboplatin (nsc 241240) by single monthly 30-minute infusion

1986 • 86 citations

Comparative distribution and excretion of carboplatin and cisplatin in mice

1988 • 82 citations

LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN

1988 • 79 citations

Plasma free platinum pharmacokinetics in patients treated with high dose carboplatin

1987 • 77 citations

High dose cisplatin and high dose carboplatin in refractory ovarian cancer

1985 • 76 citations

Phase II trial of carboplatin in advanced malignant melanoma.

1987 • 71 citations

Phase I clinical and pharmacologic trial of carboplatin daily for 5 days.

1984 • 70 citations

Phase I study of carboplatin given on a five-day intravenous schedule.

1983 • 66 citations

Enhancement of radiation-induced cell kill by platinum complexes (carboplatin and iproplatin) in V79 cells

1986 • 65 citations

Phase 1 study of carboplatin in patients with advanced cancer, intermittent intravenous bolus, and 24-hour infusion.

1985 • 61 citations

Platinum analogue combination chemotherapy: cisplatin and carboplatin--a phase I trial with pharmacokinetic assessment of the effect of cisplatin administration on carboplatin excretion.

1987 • 57 citations

Carboplatin, ifosfamide and etoposide with mid-course vincristine and thoracic radiotherapy for 'limited' stage small cell carcinoma of the bronchus

1989 • 57 citations

Effects of second-generation platinum analogs on isolated PM-2 DNA and their cytotoxicity in vitro and in vivo.

1980 • 57 citations

A phase I-II trial of carboplatin and 5-fluorouracil combination chemotherapy in advanced carcinoma of the head and neck.

1987 • 54 citations

High-performance liquid chromatographic procedures for the analysis of carboplatin in human plasma and urine

1986 • 54 citations

Ototoxicity of Cisplatin vs. Platinum Analogs CBDCA (JM‐8) and CHIP (JM‐9)

1986 • 53 citations

Hyperthermic enhancement of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) cytotoxicity in human leukemia cells in vitro.

1987 • 51 citations

A Phase II study of carboplatin in advanced squamous cell carcinoma of the cervix (a Gynecologic Oncology Group study)

1986 • 49 citations

Phase I study of carboplatin (CBDCA) in children with cancer.

1986 • 48 citations

Phase I and Pharmacokinetic Trial of Carboplatin in Refractory Adult Leukemia

1988 • 44 citations

Cis-diammine-1, 1-cyclobutane dicarboxylate platinum II (carboplatin) in the treatment of testicular germ-cell tumours: a preliminary report

1985 • 42 citations

Carboplatin, an active drug in advanced head and neck cancer.

1986 • 38 citations

Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) in cancer patients

1983 • 37 citations

Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity

1987 • 33 citations

Carboplatin: a new platinum analog in the treatment of epidermoid carcinoma of the esophagus.

1985 • 33 citations

Phase I study and pharmacokinetics of intraperitoneal carboplatin

1985 • 31 citations

Phase II trial of carboplatin in non-small cell lung cancer.

1986 • 31 citations

Phase II trial of carboplatin in patients with advanced germ cell tumors refractory to cisplatin.

1987 • 30 citations

Pharmacokinetics of unchanged carboplatin (CBDCA) in patients with small cell lung carcinoma

1987 • 30 citations

Phase II study of carboplatin in patients with ovarian carcinoma: a National Cancer Institute of Canada Clinical Trials Group Study.

1986 • 29 citations

Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.

1986 • 27 citations

In vitro colony inhibition of carboplatin against stomach and lung cancer cell lines in comparison with cisplatin

1987 • 26 citations

Combination chemotherapy with carboplatin, etoposide, and vincristine as first-line treatment in small-cell lung cancer.

1992 • 22 citations

A phase II study of carboplatin in advanced or metastatic stomach cancer

1987 • 21 citations

Renal dysfunction following high-dose carboplatin treatment

1988 • 20 citations

Phase II trial of carboplatin in patients with adenocarcinomas of the upper gastrointestinal tract.

1985 • 18 citations

Phase II Study of Carboplatin in Small Cell Lung Cancer

1988 • 17 citations

The effect of diethyldithiocarbamate on the haematological toxicity and antitumour activity of carboplatin

1987 • 16 citations

Carboplatin for advanced colorectal carcinoma: a phase II study.

1986 • 14 citations

Redox behaviour of anti-tumor platinum (II) compounds (carboplatin) at solid electrodes

1987 • 13 citations

Cell survival in four ovarian carcinoma xenografts following in vitro exposure to melphalan, cisplatin and cis-diammine-1,1-cyclobutane dicarboxylate platinum II (CBDCA, JM8)

1984 • 12 citations

Carboplatin: the clinical evaluation strategy

1985 • 12 citations

Pilot study of cyclophosphamide plus carboplatin in advanced ovarian carcinoma.

1987 • 11 citations

Carboplatin for advanced colorectal carcinoma: a phase II study.

1986 • 10 citations

Limited activity of carboplatin in malignant lymphoma.

1986 • 10 citations

Carboplatin in advanced, refractory germ cell neoplasms: a phase II Eastern Cooperative Oncology Group Study.

1987 • 10 citations

Response of nude mouse-grown human urothelial cancer to cis-diamminedichloroplatinum(II), diammine[1,1-cyclobutanedicarboxylato(2-)-O,O'-platinum], and mitoguazone dihydrochloride.

1985 • 10 citations

A pilot study of CHAC-1

1985 • 9 citations

Comparison of platinum concentrations in human head and neck tumours following administration of carboplatin, iproplatin or cisplatin.

1987 • 8 citations

Priming reduces the bone marrow toxicity of carboplatin

1987 • 7 citations

Antitumor activity against human tumor samples of cis-diamminedichloroplatinum(II) and analogues at equivalent in vitro myelotoxic concentrations.

1988 • 7 citations

Cisplatin and carboplatin in combination with etoposide as a treatment for non-small cell lung cancer: the experience of the eortc lung cancer working party

1988 • 5 citations

A phase II study of carboplatin in metastatic transitional cell carcinoma of the bladder (a report of the Medical Research Council Working Party on Urological Cancer, Subgroup in Advanced Bladder Cancer).

1987 • 5 citations