Production of Cytokines by Human Melanoma Cells and Melanocytes

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

1989 • 1,060 citations

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

1987 • 983 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.

1989 • 511 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.

1993 • 411 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Human Recombinant Granulocyte-Macrophage Colony-Stimulating Factor: A Multilineage Hematopoietin

1985 • 374 citations

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

1988 • 357 citations

Factors Affecting B-Cell Growth and Differentiation

1985 • 354 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Interleukin-10

1992 • 303 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.

1992 • 235 citations

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

1993 • 233 citations

Antitumor activity of recombinant interleukin 6 in mice.

1990 • 230 citations

Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.

1991 • 225 citations

Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.

1986 • 207 citations

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice.

1990 • 199 citations

Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes

1991 • 176 citations

Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8

1990 • 175 citations

Melanoma growth stimulatory activity: Isolation from human melanoma tumors and characterization of tissue distribution

1988 • 169 citations

A possible autocrine role for interleukin-6 in two lymphoma cell lines

1989 • 162 citations

Expression of interleukin 10 in human melanoma

1994 • 147 citations

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

1993 • 140 citations

Expression and Secretion of Leukocyte Chemotactic Cytokines by Normal Human Melanocytes and Melanoma Cells

1991 • 96 citations

Expression of cytokine genes, including IL-6, in human malignant melanoma cell lines

1992 • 93 citations

In Vivo Administration of Interleukin 1 to Normal Mice Depresses Their Capacity to Elicit Contact Hypersensitivity Responses: Prostaglandins Are Involved in This Modification of Immune Function

1987 • 87 citations

Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro.

1991 • 81 citations

Cytokine‐mediated modulation of HLA‐class II, ICAM‐1, LFA‐3 and tumor‐associated antigen profile of melanoma cells. comparison with anti‐proliferative activity by RIL1‐β, RTNF‐α, RIFN‐γ, RIl4 and their combinations

1990 • 81 citations

Reduced tumorigenicity of fibrosarcomas which constitutively generate il‐1α either spontaneously or following il‐1α gene transfer

1992 • 75 citations

Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line.

1983 • 73 citations

In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells.

1992 • 71 citations

Production of interleukin 1 activity by cultured human melanoma cells.

1989 • 71 citations

Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.

1993 • 66 citations

Expression and Release of Interleukin-1 by Different Human Melanoma Cell Lines

1989 • 66 citations

Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines.

1989 • 62 citations

Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.

1990 • 60 citations

Macrophage colony‐stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression

1993 • 51 citations

Eosinophils infiltrating interleukin‐5 gene‐transfected tumors do not suppress tumor growth

1993 • 50 citations

Heterogeneity of cytokine production by human malignant melanoma cells

1992 • 45 citations

Stimulation of tumor necrosis factor release from monocytic cells by the A375 human melanoma via granulocyte-macrophage colony-stimulating factor.

1990 • 42 citations

Immunohistological and immunoelectron microscopic identification of TNF? in normal human and murine epidermis

1992 • 32 citations

Preparation of a monoclonal antibody to a melanoma growth‐stimulatory activity released into serum‐free culture medium by Hs0294 malignant melanoma cells

1987 • 31 citations

Cytostatic and Cytotoxic Effects of Recombinant Tumor Necrosis Factor-α on Sensitive Human Melanoma Cells In Vitro May Result in Selection of Cells with Enhanced Markers of Malignancy

1990 • 21 citations

Immunolocation of TNF-Alpha/Cachectin in Human Melanoma Cells: Studies on Co-Cultivated Malignant Melanoma

1991 • 13 citations

Proliferation and morphology of melanoma cells and benign human melanocytes under varying culture conditions.

1993 • 12 citations

Identification of genes specifically regulated in melanoma cells

1993 • 6 citations

Deleted Work

1955 • 0 citations

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