Caspase-3 Activation after Neonatal Rat Cerebral Hypoxia-Ischemia

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Caspases: killer proteases

1997 • 2,440 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Brassinosteroids Rescue the Deficiency of CYP90, a Cytochrome P450, Controlling Cell Elongation and De-etiolation in Arabidopsis

1996 • 989 citations

Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

1998 • 899 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

1998 • 706 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

1998 • 554 citations

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

1998 • 514 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Fodrin: axonally transported polypeptides associated with the internal periphery of many cells.

1981 • 480 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Involvement of Caspase-3 in Cell Death after Hypoxia–Ischemia Declines during Brain Maturation

2000 • 339 citations

Caspases – controlling intracellular signals by protease zymogen activation

2000 • 329 citations

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1998 • 307 citations

Spatial resolution of fodrin proteolysis in postischemic brain.

1993 • 270 citations

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

1998 • 270 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia

1998 • 203 citations

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1998 • 202 citations

Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease)

1999 • 168 citations

Synergistic effects of caspase inhibitors and MK‐801 in brain injury after transient focal cerebral ischaemia in mice

1998 • 166 citations

Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons

1998 • 164 citations

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

1997 • 158 citations

Correlation Between Caspase‐3 Activation and Three Different Markers of DNA Damage in Neonatal Cerebral Hypoxia‐Ischemia

2000 • 116 citations

Enhanced Poly(ADP-ribosyl)ation after Focal Ischemia in Rat Brain

1998 • 113 citations

Calpastatin Is Up-regulated in Response to Hypoxia and Is a Suicide Substrate to Calpain after Neonatal Cerebral Hypoxia-Ischemia

1999 • 112 citations

Functional Differences of Two Forms of the Inhibitor of Caspase-activated DNase, ICAD-L, and ICAD-S

1999 • 94 citations

Functional Interaction of DFF35 and DFF45 with Caspase-activated DNA Fragmentation Nuclease DFF40

1999 • 80 citations

Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.

1995 • 79 citations

Neuronal accumulation of poly(ADP‐ribose) after brain ischaemia

1999 • 74 citations

A Method for Protein Assay in Laemmli Buffer

1994 • 73 citations

Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia

1995 • 54 citations

Species differences in fodrin proteolysis in the ischemic brain

1999 • 21 citations