Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

The molecular biology of apoptosis.

1996 • 963 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

A License to Kill

1996 • 649 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Induction of a Common Pathway of Apoptosis by Staurosporine

1994 • 491 citations

Calpain activation in apoptosis

1994 • 445 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1989 • 359 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in Madin-Darby canine kidney epithelial cells.

1990 • 294 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase.

1986 • 254 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Involvement of Cellular Proteolytic Machinery in Apoptosis

1997 • 184 citations

The calmodulin-binding site in alpha-fodrin is near the calcium-dependent protease-I cleavage site.

1988 • 150 citations

Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster.

1993 • 143 citations

Chapter 17 Chapter The nature and causes of hippocampal long-term potentiation

1990 • 138 citations

Brain spectrin, calpain and long-term changes in synaptic efficacy

1987 • 136 citations

Calmodulin and calcium-dependent protease I coordinately regulate the interaction of fodrin with actin.

1990 • 131 citations

Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

1994 • 131 citations

Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis

1996 • 121 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Location of the human red cell spectrin tetramer binding site and detection of a related “closed” hairpin loop dimer using proteolytic footprinting.

1993 • 105 citations

Characterization of CPP32‐Like Protease Activity Following Apoptotic Challenge in SH‐SY5Y Neuroblastoma Cells

1997 • 96 citations

Characterization of human brain cDNA encoding the general isoform of beta-spectrin.

1992 • 87 citations

Site-Directed Mutagenesis of αII Spectrin at Codon 1175 Modulates Its μ-Calpain Susceptibility

1997 • 83 citations

Proteolytic processing of human brain alpha spectrin (fodrin): identification of a hypersensitive site

1988 • 82 citations

Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2).

1994 • 73 citations

Stimulation of NMDA receptors activates calpain in cultured hippocampal slices

1994 • 66 citations

Calmodulin Regulates Fodrin Susceptibility to Cleavage by Calciumdependent Protease I

1989 • 66 citations

Maitotoxin Induces Calpain Activation in SH-SY5Y Neuroblastoma Cells and Cerebrocortical Cultures

1996 • 61 citations

In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s).

1991 • 61 citations

Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity

1991 • 51 citations

Mechanisms of cytoskeletal regulation: Functional and antigenic diversity in human erythrocyte and brain beta spectrin

1986 • 48 citations

Drosophila development requires spectrin network formation.

1995 • 41 citations