Calpastatin Is Up-regulated in Response to Hypoxia and Is a Suicide Substrate to Calpain after Neonatal Cerebral Hypoxia-Ischemia

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Neurology of the newborn.

1981 • 2,890 citations

Comparative aspects of the brain growth spurt

1979 • 2,491 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

1991 • 841 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Fodrin: axonally transported polypeptides associated with the internal periphery of many cells.

1981 • 480 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Calcium Accumulation and Neuronal Damage in the Rat Hippocampus following Cerebral Ischemia

1987 • 374 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

1994 • 314 citations

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1998 • 307 citations

Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

1984 • 294 citations

Spatial resolution of fodrin proteolysis in postischemic brain.

1993 • 270 citations

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

1998 • 270 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN

1974 • 235 citations

Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.

1996 • 223 citations

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

1994 • 219 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1998 • 202 citations

Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

1994 • 183 citations

Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo

1993 • 170 citations

Hypoxia-Ischemia in the Neonatal Rat Brain: Histopathology after Post-Treatment with NMDA and Non NMDA Receptor Antagonists

1994 • 155 citations

Tyrosine Phosphorylation and Activation of Mitogen‐ Activated Protein Kinase in the Rat Brain Following Transient Cerebral Ischemia

1994 • 147 citations

The Bovine Calpastatin Gene Promoter and a New N-terminal Region of the Protein Are Targets for cAMP-dependent Protein Kinase Activity

1998 • 110 citations

Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.

1992 • 103 citations

Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.

1994 • 81 citations

The Role of the Calpain-Calpastatin System in Thyrotropin-releasing Hormone-induced Selective Down-regulation of a Protein Kinase C Isozyme, nPKCε, in Rat Pituitary GH4C1 Cells

1995 • 81 citations

Proteolysis of the calcium-dependent protease inhibitor by myocardial calcium-dependent protease

1986 • 81 citations

Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.

1995 • 79 citations

Fragmentation of an endogenous inhibitor upon complex formation with high- and low-calcium requiring forms of calcium-activated neutral proteases

1989 • 77 citations

Calcium Accumulation during the Evolution of Hypoxic—Ischemic Brain Damage in the Immature Rat

1988 • 76 citations

A Method for Protein Assay in Laemmli Buffer

1994 • 73 citations

Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease

1989 • 60 citations

Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells

1991 • 58 citations

Modulation of rat brain calpastatin efficiency by post‐translational modifications

1997 • 57 citations

Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit

1993 • 55 citations

Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia

1995 • 54 citations

Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemia

1993 • 53 citations

Degradation of fodrin and MAP 2 after neonatal cerebral hypoxic-ischemia

1995 • 52 citations

m-Calpain requires DNA for activity on nuclear proteins at low calcium concentrations.

1993 • 47 citations

Isolation and Characterization of Monoclonal Antibodies against Calcium-Activated Neutral Protease with Low Calcium Sensitivity1

1986 • 42 citations

Management of labor

1983 • 40 citations

Repetitive region of calpastatin is a functional unit of the proteinase inhibitor

1987 • 39 citations

Calpain-Calpastatin Interactions in Epidermoid Carcinoma KB Cells1

1994 • 38 citations

Purification and characterization of a protein inhibitor of calcium-dependent proteases from rat liver

1984 • 37 citations

Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus

1997 • 36 citations

Properties of calpastatin forms in rat brain

1998 • 34 citations

Subcellular Distribution of Calpain and Calpastatin Immunoreactivity and Fodrin Proteolysis in Rabbit Hippocampus After Hypoxia and Glucocorticoid Treatment

1994 • 30 citations

Developmental changes of calpain and calpastatin in rabbit brain

1989 • 29 citations

The calpain—calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells

1994 • 25 citations

On the mechanism of binding of calpastatin, the protein inhibitor of calpains, to biologic membranes

1988 • 25 citations

Changes in extracellular calcium concentration in the immature rat cerebral cortex during anoxia are not influenced by MK-801

1994 • 22 citations

Recent Advances in Paediatrics 10

1993 • 13 citations