Slow-Channel Myasthenic Syndrome Caused By Enhanced Activation, Desensitization, and Agonist Binding Affinity Attributable to Mutation in the M2 Domain of the Acetylcholine Receptor α Subunit

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Data transformations for improved display and fitting of single-channel dwell time histograms

1987 • 828 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

On the stochastic properties of single ion channels

1981 • 667 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Chapter 9 The End of the (Cell) Line: Methods for the Study of Apoptosis in Vitro

1995 • 569 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

A suggested nomenclature for designating mutations

1993 • 317 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1995 • 263 citations

A newly recognized congenital myasthenic syndrome attributed to a prolonged open time of the acetylcholine‐induced ion channel

1982 • 259 citations

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

1995 • 252 citations

Ultrastructural localization of the acetylcholine receptor in myasthenia gravis and in its experimental autoimmune model

1977 • 244 citations

A new myasthenic syndrome with end‐plate acetylcholinesterase deficiency, small nerve terminals, and reduced acetylcholine release

1977 • 236 citations

Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

1996 • 234 citations

Relationship between membrane excitability and single channel open-close kinetics

1983 • 221 citations

Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by high concentrations of agonist.

1987 • 194 citations

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

1990 • 193 citations

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

1996 • 190 citations

A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671

1989 • 186 citations

Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line

1991 • 180 citations

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1995 • 174 citations

End‐plate acetylcholine receptor deficiency due to nonsense mutations in the ε subunit

1996 • 150 citations

Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors

1994 • 146 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.

1989 • 137 citations

Activation of a nicotinic acetylcholine receptor

1984 • 132 citations

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

1993 • 130 citations

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

1994 • 129 citations

Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by low concentrations of agonist.

1986 • 123 citations

The human medulloblastoma cell line TE671 expresses a muscle‐like acetylcholine receptor Cloning of the α‐subunit cDNA

1988 • 110 citations

A β‐subunit mutation in the acetylcholine receptor channel gate causes severe slow‐channel syndrome

1996 • 106 citations

Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium.

1995 • 82 citations

Calcium permeability increase of endplate channels in rat muscle during postnatal development.

1996 • 78 citations

Primary structure of the human muscle acetylcholine receptor

1993 • 73 citations

Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di‐, mono‐ and unliganded receptors.

1996 • 73 citations

Congenital myasthenic syndromes: II. Syndrome attributed to abnormal interaction of acetylcholine with its receptor

1993 • 70 citations

Congenital myasthenic syndromes: I. Deficiency and short open‐time of the acetylcholine receptor

1993 • 70 citations

Patch‐clamp analysis of the properties of acetylcholine receptor channels at the normal human endplate

1994 • 42 citations

Nucleotide sequence of human muscle acetylcholine receptor β-subunit

1989 • 37 citations