Astrocytes and Microglia Produce Interleukin-12 p40

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.

1990 • 604 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

The role of interleukin 12 in the immune response, disease and therapy

1994 • 221 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Identification and induction of human keratinocyte-derived IL-12.

1994 • 137 citations

On the role of astrocytes in polyclonal T cell activation

1986 • 13 citations

Immune response to brain tumors

1992 • 6 citations