The biochemical pharmacology of thromboxane synthase inhibition in man.

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects

1982 • 940 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

Controlled trial of aspirin in cerebral ischemia.

1977 • 633 citations

"AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia.

1983 • 615 citations

EFFECTS OF SALICYLATES ON HUMAN PLATELETS

1968 • 564 citations

Dose-Related Kinetics of Aspirin

1984 • 552 citations

A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations

1982 • 550 citations

Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations

1984 • 529 citations

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

1974 • 517 citations

Increased Prostacyclin Biosynthesis in Patients with Severe Atherosclerosis and Platelet Activation

1984 • 510 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

ASPIRIN AND SECONDARY MORTALITY AFTER MYOCARDIAL INFARCTION

1979 • 361 citations

IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY)

1984 • 319 citations

Prostacyclin is not a circulating hormone in man

1982 • 290 citations

Estimated rate of prostacyclin secretion into the circulation of normal man.

1981 • 271 citations

Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin

1979 • 248 citations

Platelet and Blood Vessel Arachidonate Metabolism and Interactions

1979 • 181 citations

ADMINISTRATION TO MAN OF UK-37,248-01, A SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE

1981 • 168 citations

Membranoproliferative Glomerulonephritis

1984 • 163 citations

THROMBOXANE SYNTHETASE INHIBITION AS ANTITHROMBOTIC STRATEGY

1981 • 145 citations

ANTAGONISM OF THE THROMBOXANE‐SENSITIVE CONTRACTILE SYSTEMS OF THE RABBIT AORTA, DOG SAPHENOUS VEIN AND GUINEA‐PIG TRACHEA

1982 • 142 citations

Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

1983 • 138 citations

Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.

1984 • 122 citations

Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis.

1981 • 120 citations

13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.

1979 • 113 citations

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid.

1977 • 111 citations

Albumins stabilize prostaglandin I2

1980 • 88 citations

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

1986 • 87 citations

Aspirin kinetics and platelet aggregation in man

1983 • 70 citations

Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome

1984 • 68 citations

A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid Two selective thromboxane synthetase inhibitors

1978 • 63 citations

Controlled double-blind trial of dazoxiben and nifedipine in the treatment of Raynaud's phenomenon

1984 • 57 citations

Selective and nonselective inhibition of thromboxane formation

1984 • 56 citations

Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing

1985 • 54 citations

SPECIFIC THROMBOXANE SYNTHETASE INHIBITION AND ALBUMIN EXCRETION RATE IN INSULIN-DEPENDENT DIABETES

1984 • 54 citations

Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products

1984 • 48 citations

Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.

1984 • 47 citations

Effects of dazoxiben on arrhythmias and ventricular fibrillation induced by coronary artery occlusion and reperfusion in anaesthetised greyhounds.

1983 • 46 citations

N-0164 inhibits generation of thromboxane-A2-like activity from prostaglandin endoperoxides by human platelet microsomes

1976 • 45 citations

Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products

1984 • 43 citations

Beneficial effects of a new thromboxane synthetase inhibitor in arachidonate-induced sudden death

1981 • 41 citations

Effects of a selective thromboxane synthetase inhibitor, dazoxiben, and of acetylsalicylic acid on myocardial ischemia in patients with coronary artery disease

1984 • 39 citations

Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: a double-blind trial.

1983 • 39 citations

Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity.

1983 • 33 citations

Potentiation by dazoxiben, a thromboxane synthetase inhibitor, of platelet aggregation inhibitory activity of a thromboxane receptor antagonist and of prostacyclin

1982 • 31 citations

Effects of dazoxiben on exercise performance in chronic stable angina.

1983 • 31 citations

Effect of selective inhibitor of thromboxane A2 synthetase on experimental cerebral vasospasm.

1984 • 30 citations

redirection of prostaglandin endoperoxides into 6-keto PGF1α formation by thromboxane synthetase inhibitors in the rat

1983 • 30 citations

Inhibition of thromboxane biosynthesis in serum: Limitations of the measurement of immunoreactive 6-KETO-PGF1α

1984 • 27 citations

Prostacyclin in blood vessel–platelet interactions: perspectives and questions

1979 • 25 citations

Sulphinpyrazone metabolism during long‐term therapy.

1981 • 24 citations

SQ 22536, an Adenylate-Cyclase Inhibitor, Prevents the Antiplatelet Effect of Dazoxiben, a Thromboxane-Synthetase Inhibitor

1984 • 21 citations

Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing.

1983 • 18 citations

Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248‐01).

1983 • 17 citations

Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production.

1983 • 16 citations

Effects of UK 37248, a Thromboxane Synthetase Inhibitor, on Platelet Behaviour in Patients with Coronary Heart Disease (CHD) Undergoing Exercise to Angina

1982 • 4 citations