DNA repair in drug resistance: Studies on the repair process at the level of the gene

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

The SOS regulatory system of Escherichia coli

1982 • 1,491 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

DNA REPAIR ENZYMES

1988 • 822 citations

DNA repair: a laboratory manual of research procedures

1981 • 818 citations

THE BIOLOGY OF THE (6–4) PHOTOPRODUCT

1989 • 604 citations

Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand

1989 • 576 citations

The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes

1987 • 533 citations

Preferential DNA repair of an active gene in human cells.

1986 • 455 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

Mitomycin C: a review

1976 • 441 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

Heterogeneous DNA damage and repair in the mammalian genome.

1987 • 274 citations

Interaction of bleomycin with DNA.

1978 • 250 citations

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

1979 • 244 citations

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

1984 • 236 citations

DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

1983 • 223 citations

Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents

1989 • 218 citations

Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy.

1987 • 216 citations

Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.

1978 • 206 citations

Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos

1986 • 202 citations

DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.

1977 • 200 citations

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1988 • 196 citations

Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene.

1986 • 196 citations

DNA repair and its inhibition

1984 • 174 citations

Mechanism of action of cis-dichlorodiammineplatinum(II).

1979 • 173 citations

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines

1989 • 168 citations

Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I.

1989 • 165 citations

Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells.

1991 • 157 citations

Enhanced DNA repair and resistance to cisplatin in human ovarian cancer

1988 • 156 citations

Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

1985 • 127 citations

Differential repair of UV damage inSaccharomyces cerevisiae

1989 • 118 citations

Mammalian DNA polymerases .alpha. and .delta.: current status in DNA replication

1988 • 117 citations

Differences in the regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type.

1983 • 116 citations

Reduced formation of protein-associated DNA strand breaks in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 106 citations

DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): host-cell reactivation of damaged plasmid DNA

1989 • 106 citations

Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells.

1986 • 105 citations

Dependence of mammalian DNA synthesis on DNA supercoiling. III Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid

1981 • 96 citations

Preferential DNA repair of (6-4) photoproducts in the dihydrofolate reductase gene of Chinese hamster ovary cells

1989 • 94 citations

Interactions of mitomycin C with mammalian DNA detected by alkaline elution.

1985 • 84 citations

Evaluation of platinum-DNA adduct levels relative to known prognostic variables in a cohort of ovarian cancer patients.

1990 • 83 citations

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 78 citations

Quantification of Aminofluorene Adduct Formation and Repair in Defined DNA sequences in Mammalian Cells Using the UVRABC Nuclease

1989 • 77 citations

The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA.

1986 • 76 citations

Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea.

1988 • 74 citations

Structure-function studies of the T4 endonuclease V repair enzyme

1989 • 73 citations

Differential repair of DNA damage in the human metallothionein gene family.

1988 • 70 citations

DNA Repair and Its Pathogenetic Implications

1990 • 69 citations

Inhibition of chemical transformation in C3H/10T1/2 cells by protease inhibitors.

1979 • 69 citations

DNA repair in the metallothionein gene increases with transcriptional activation

1987 • 65 citations

Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.

1990 • 63 citations

1-beta-D-arabinofuranosylcytosine and hydroxyurea production of cytotoxic synergy with cis-diamminedichloroplatinum(II) and modification of platinum-induced DNA interstrand cross-linking.

1989 • 56 citations

Resistance to antineoplastic drugs

1989 • 53 citations

Elevated DNA polymerase beta activity in a cis-diamminedichloroplatinum(II) resistant P388 murine leukemia cell line

1988 • 47 citations

Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells.

1989 • 47 citations

Anticarcinogenic potential of DNA-repair modulators

1988 • 42 citations

β-Lapachone greatly enhances MMS lethality to human fibroblasts

1984 • 42 citations

Mechanism of bleomycin: evidence for 4'-ketone formation in poly(dA-dU) associated exclusively with free base release

1985 • 41 citations

Modulation of nitrosourea resistance in myeloid leukemias

1988 • 39 citations

Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo.

1989 • 39 citations

3-aminobenzamide stimulates unscheduled dna synthesis and rejoining of strand breaks in human lymphocytes

1981 • 36 citations

The accumulation of DNA breaks due to incision; comparative studies with various inhibitors.

1984 • 36 citations

Involvement of DNA polymerase .delta. in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation

1988 • 36 citations

Heterogeneous repair of methylnitrosourea-induced alkali-labile sites in different DNA sequences.

1991 • 35 citations

Inhibition of DNA repair by inhibitors of nuclear ADP-ribosyl transferase.

1984 • 33 citations

Inhibition of DNA repair by trifluoperazine

1985 • 31 citations

Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin.

1989 • 30 citations

The repair of identified large DNA adducts induced by 4-nitroquinoline-1-oxide in normal or xeroderma pigmentosum group A human fibroblasts, and the role of DNA polymerases α or δ

1989 • 26 citations

Multiple mechanisms of adriamycin resistance in the human leukemia cell line CCRF-CEM

1989 • 25 citations

Alteration of the secondary structure of newly synthesized DNA from murine bone marrow cells by 5-fluorouracil.

1986 • 23 citations

Drug sensitivity and some characteristics of a bleomycin-resistant subline of mouse lymphoblastoma L5178Y cells.

1981 • 21 citations

Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells

1991 • 21 citations

Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines.

1989 • 18 citations

Experimental studies at Southern Research Institute with DTIC (NSC-45388).

1976 • 17 citations

Comparative effects of growth inhibitors on DNA replication, DNA repair, and protein synthesis in human epidermal keratinocytes.

1986 • 14 citations

Enhancement of adriamycin-induced cytotoxicity by increasing retention and inhibition of DNA repair in DOX-resistant P388 cell lines with new calcium channel blocker, DMDP.

1989 • 14 citations

Analysis of repair synthesis in the presence of inhibitors.

1984 • 13 citations

Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.

1986 • 12 citations

G2 effects of DNA-repair inhibitors on chromatid-type aberrations in root-tip cells treated with maleic hydrazide and mitomycin C

1989 • 12 citations

Chapter 10. Systemic Therapy Of Indignant Disease

1986 • 9 citations

The effect of inhibitors of DNA synthesis on DNA repair.

1984 • 9 citations

マレイン酸ヒドラジドとマイトマイシンC処理した根端細胞の,染色分体型異常に対するDNA修復阻害剤のG 2 効果

1989 • 8 citations

Effect of Inhibitors of Poly(ADP-Ribose)Polymerase on the Radiation Response of HeLa S3 Cells

1989 • 8 citations

Further Characterization of Bleomycin‐resistant HeLa Cells and Analysis of Resistance Mechanism

1988 • 8 citations

Instability of Mex− phenotype in human lymphoblastoid cell lines

1988 • 8 citations

Inhibition of repair patch ligation by an inhibitor of poly(ADP-ribose) synthesis in normal human fibroblasts damaged with ultraviolet radiation.

1988 • 7 citations

An investigation using inhibition of G2 repair of the molecular basis of lesions which result in chromosomal aberrations

1988 • 7 citations

Peripheral Blood Leukocytes as a Surrogate Marker for Cisplatin Drug Resistance: Studies of Adduct Levels and the Repair Gene ERCC1

1990 • 6 citations

In vivo DNA damage and resistance to 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea in L1210 leukemia cells.

1988 • 5 citations

Preclinical and Clinical Experiences with Drug Combinations Designed to Inhibit DNA Repair in Resistant Human Tumor Cells

1988 • 5 citations

Cell-cycle, phase-specific cell killing by carmustine in sensitive and resistant cells.

1988 • 5 citations

The influence of cathepsin B and leupeptin on potentially lethal damage repair in mammalian cells

1989 • 4 citations