Signaling to the Mammalian Circadian Clocks: In Pursuit of the Primary Mammalian Circadian Photoreceptor

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

Molecular Analysis of Mammalian Circadian Rhythms

2001 • 1,428 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

2000 • 1,112 citations

Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.

1979 • 968 citations

The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila

1998 • 952 citations

Melanopsin: An opsin in melanophores, brain, and eye

1998 • 927 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity

1998 • 861 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

1998 • 820 citations

Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors

1999 • 819 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

Circadian oscillation of a mammalian homologue of the Drosophila period gene

1997 • 782 citations

A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

1996 • 776 citations

Phytochromes and Cryptochromes in the Entrainment of the Arabidopsis Circadian Clock

1998 • 770 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

1992 • 690 citations

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

1974 • 682 citations

Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2

1999 • 668 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

Structure and function of DNA photolyase

1994 • 658 citations

Suppression of Melatonin Secretion in Some Blind Patients by Exposure to Bright Light

1995 • 643 citations

Independent Photoreceptive Circadian Clocks Throughout Drosophila

1997 • 628 citations

Melatonin receptors: Localization, molecular pharmacology and physiological significance

1994 • 615 citations

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

1999 • 613 citations

Resetting the Biological Clock: Mediation of Nocturnal Circadian Shifts by Glutamate and NO

1994 • 570 citations

GABA is the principal neurotransmitter of the circadian system

1993 • 551 citations

Regulation of the Mammalian Pineal by Non-rod, Non-cone, Ocular Photoreceptors

1999 • 511 citations

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

2001 • 465 citations

Light acts directly on organs and cells in culture to set the vertebrate circadian clock

2000 • 448 citations

Neuropeptide Y: Role in light-dark cycle entrainment of hamster circadian rhythms

1984 • 448 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

Vitamin B ₂ -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals

1998 • 402 citations

Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

1998 • 397 citations

CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications

1997 • 393 citations

Neural control of the pineal gland

1995 • 381 citations

mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

2001 • 376 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

1998 • 364 citations

Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators

1998 • 348 citations

The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells

1995 • 345 citations

Pinopsin is a chicken pineal photoreceptive molecule

1994 • 341 citations

The role of glutamate in the photic regulation of the suprachiasmatic nucleus

1996 • 319 citations

Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain

1998 • 305 citations

Signaling routes to CREM and CREB: plasticity in transcriptional activation

1999 • 304 citations

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

2000 • 291 citations

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei

1999 • 282 citations

Intergeniculate leaflet: An anatomically and functionally distinct subdivision of the lateral geniculate complex

1994 • 280 citations

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

2000 • 270 citations

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

2000 • 268 citations

Encephalopsin: A Novel Mammalian Extraretinal Opsin Discretely Localized in the Brain

1999 • 261 citations

Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception

2000 • 260 citations

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene

2001 • 251 citations

Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus

1985 • 245 citations

Resetting the Biological Clock: Mediation of Nocturnal CREB Phosphorylation via Light, Glutamate, and Nitric Oxide

1997 • 243 citations

Antiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats

1998 • 235 citations

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT

1998 • 234 citations

A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock

1998 • 229 citations

Chapter 8 Entrainment pathways and the functional organization of the circadian system

1996 • 223 citations

A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus

1998 • 220 citations

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site Usage

1997 • 219 citations

Multilevel regulation of the circadian clock

2000 • 219 citations

Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

1995 • 198 citations

Dimerization and nuclear entry of mPER proteins in mammalian cells

2000 • 191 citations

Rhythmic Properties of the Hamster Suprachiasmatic NucleusIn Vivo

1998 • 180 citations

Circadian Oscillation ofBMAL1,a Partner of a Mammalian Clock GeneClock,in Rat Suprachiasmatic Nucleus

1998 • 178 citations

Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.

1988 • 176 citations

A cell-based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock

2001 • 172 citations

Pituitary adenylyl cyclase-activating peptide: A pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock

1999 • 170 citations

Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice

2000 • 166 citations

Visual Pathways and the Entrainment of Circadian Rhythms^a

1985 • 165 citations

NMDA as Well as Non-NMDA Receptor Antagonists Can Prevent the Phase-Shifting Effects of Light on the Circadian System of the Golden Hamster

1992 • 164 citations

Pineal Opsin: a Nonvisual Opsin Expressed in Chick Pineal

1995 • 163 citations

Effects of age on the circadian system

1995 • 161 citations

Effects of Stimulated Physical Activity on the Circadian Pacemaker of Vertebrates 1

1989 • 161 citations

A novel and ancient vertebrate opsin

1997 • 157 citations

Transcriptional control of circadian hormone synthesis via the CREM feedback loop

1996 • 148 citations

Transcriptionally Active Heterodimer Formation of an Arnt-like PAS Protein, Arnt3, with HIF-1a, HLF, and Clock

1998 • 145 citations

Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues

2000 • 143 citations

Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε

2000 • 135 citations

Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host

2000 • 127 citations

Circadian actions of melatonin at the suprachiasmatic nucleus

1995 • 124 citations

Behavioral and Serotonergic Regulation of Circadian Rhythms

2000 • 123 citations

Components and connections of the circadian timing system in mammals

1996 • 113 citations

Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues

1998 • 106 citations

Large phase-shifts of circadian rhythms caused by induced running in a re-entrainment paradigm: The role of pulse duration and light

1989 • 104 citations

No Evidence for Extraocular Photoreceptors in the Circadian System of the Syrian Hamster

1999 • 100 citations

Neuropeptide Y and optic chiasm stimulation of affect suprachiasmatic nucleus circadian function in vitro

1993 • 97 citations

Glutamate shifts the phase of the circadian neuronal firing rhythm in the rat suprachiasmatic nucleus in vitro

1994 • 96 citations

Rhythmic transcription: The molecular basis of circadian melatonin synthesis

1997 • 69 citations

The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA

1995 • 50 citations

Functional absence of extraocular photoreception in hamster circadian rhythm entrainment

1999 • 35 citations

Circadian Rhythms: ICER is nicer at night (sir!)

1994 • 35 citations

Developmental maturation of pineal gland function: synchronized CREM inducibility and adrenergic stimulation

1995 • 35 citations

Involvement of glutamate release in substance P-induced phase delays of suprachiasmatic neuron activity rhythm in vitro

1999 • 29 citations

SNC 80, a delta-opioid agonist, elicits phase advances in hamster circadian activity rhythms

2000 • 18 citations

Seasonal affective disorder: its recognition and treatment

1999 • 8 citations