Activation of the c-src Gene

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.

1983 • 193 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants.

1977 • 151 citations

Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src

1983 • 138 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60^c-src Relative to pp60^v-src

1985 • 119 citations

DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains

1984 • 60 citations

Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation

1985 • 53 citations

Lack of Induction of Neuroretinal Cell Proliferation by Rous Sarcoma Virus Variants That Carry the c-src Gene

1985 • 25 citations

Partial nucleotide sequence of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication defective

1985 • 24 citations