Proteolytic Processing of the β-Subunit of the Lysosomal Enzyme, β-Hexosaminidase, in Normal Human Fibroblasts

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Compilation of published signal sequences

1984 • 784 citations

Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

1986 • 176 citations

Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.

1985 • 162 citations

Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.

1984 • 159 citations

Gene encoding the human beta-hexosaminidase beta chain: extensive homology of intron placement in the alpha- and beta-chain genes.

1988 • 115 citations

Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.

1982 • 113 citations

A profusion of controls.

1988 • 107 citations

Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

1988 • 79 citations

Proteolytic processing of the alpha-chain of the lysosomal enzyme, beta-hexosaminidase, in normal human fibroblasts.

1988 • 63 citations

Evidence for two dissimilar polypeptide chains in the beta 2 subunit of hexosaminidase.

1982 • 50 citations

Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B, in a cell-free system.

1988 • 42 citations

Localization of the pro‐sequence within the total deduced primary structure of human β‐hexosaminidase B

1988 • 20 citations

A structural difference between the β-chains in hexosaminidase B and hexosaminidase A

1981 • 14 citations