Gene encoding the human beta-hexosaminidase beta chain: extensive homology of intron placement in the alpha- and beta-chain genes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Genes-in-Pieces Revisited

1985 • 362 citations

Isolation and structural organization of the human preproenkephalin B gene

1983 • 351 citations

THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS

1980 • 306 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

Rapid restriction mapping of DNA cloned in lambda phage vectors

1984 • 250 citations

Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.

1985 • 223 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion.

1985 • 182 citations

Structure of two related rat pancreatic trypsin genes.

1984 • 177 citations

Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

1986 • 176 citations

Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.

1985 • 162 citations

Rapid purification of plasmid DNA by a single centrifugation in a two-step cesium chloride-ethidium bromide gradient

1983 • 161 citations

A deletion involving Alu sequences in the beta-hexosaminidase alpha-chain gene of French Canadians with Tay-Sachs disease.

1987 • 148 citations

Organization of the gene encoding the human beta-hexosaminidase alpha-chain.

1987 • 127 citations

Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase.

1985 • 116 citations

Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.

1982 • 113 citations

Comparative analysis of the structural organization of two closely related vitellogenin genes in X. laevis

1980 • 106 citations

Molecular heterogeneity in the infantile and juvenile forms of Sandhoff disease (O-variant GM2 gangliosidosis).

1986 • 88 citations

The Tay-Sachs disease gene in North American Jewish populations: geographic variations and origin.

1983 • 78 citations

Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.

1987 • 73 citations

The Biochemical Basis of Gangliosidoses

1984 • 59 citations

Genetic variants of Tay-Sachs disease: Tay-Sachs disease and Sandhoff's disease in French Canadians, juvenile Tay-Sachs disease in Lebanese Canadians, and a Tay-Sachs screening program in the French-Canadian population.

1977 • 54 citations

The lysosomal hexosaminidase isozymes.

1985 • 41 citations

Evidence for the presence of ?-subunit of hexosaminidase in a case of Sandhoff disease using a blotting technique

1983 • 9 citations