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Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B, in a cell-free system.

Data up to Jan 2025

Published1988
Citations42
References31

Total Citations Per Year

Abstract

References (31)

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Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.

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Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.

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Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

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Proteolytic processing of the alpha-chain of the lysosomal enzyme, beta-hexosaminidase, in normal human fibroblasts.

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Faulty association of alpha- and beta-subunits in some forms of beta-hexosaminidase A deficiency.

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Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B,… (1988) – Journal of Biological Chemistry | Metascience Observatory Explorer