The Interleukin-1 Axis and Cutaneous Inflammation.

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Recognition by Elam-1 of the Sialyl-Le ^x Determinant on Myeloid and Tumor Cells

1990 • 976 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.

1990 • 569 citations

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

1992 • 475 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.

1987 • 352 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

1991 • 326 citations

Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

1985 • 325 citations

Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein

1992 • 315 citations

Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.

1990 • 303 citations

Cloning the interleukin 1 receptor from human T cells.

1989 • 267 citations

Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

1986 • 259 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

1991 • 209 citations

An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties.

1989 • 208 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Pro-Inflammatory Levels of Interleukin-1α-Like Bioactivity Are Present in the Majority of Open Comedones in Acne Vulgaris

1992 • 180 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Interleukin-1 Receptor antagonist Production by Human Keratinocytes

1992 • 152 citations

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 • 152 citations

The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.

1993 • 149 citations

Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line.

1986 • 144 citations

IL-1 activity is reduced in psoriatic skin. Decreased IL-1 alpha and increased nonfunctional IL-1 beta.

1990 • 140 citations

Cytokines in skin lesions of psoriasis

1990 • 140 citations

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

1991 • 140 citations

Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family

1991 • 136 citations

INTERLEUKIN-1 IS A CRITICAL EFFECTOR MOLECULE DURING CYTOKINE DYSREGULATION IN GRAFT VERSUS HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS1

1993 • 134 citations

Interleukin-1 receptor antagonist in normal and psoriatic epidermis.

1992 • 126 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein

1989 • 117 citations

Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.

1988 • 110 citations

Dissection of the Protein Phosphorylation Cascades Involved in Insulin and Growth Factor Action

1993 • 103 citations

Effect of In Vivo Interleukin-1 on Adhesion Molecule Expression in Normal Human Skin

1992 • 103 citations

T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1.

1989 • 97 citations

Interleukin 1: The patterns of translation and intracellular distribution support alternative secretory mechanisms

1992 • 92 citations

Induction of an interleukin-1 receptor (IL-1R) on monocytic cells. Evidence that the receptor is not encoded by a T cell-type IL-1R mRNA.

1990 • 88 citations

Characterization of a subclone (D10S) of the D10.G4.1 helper t-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens

1989 • 88 citations

Interleukin‐1 activates phospholipase a₂ IN HUMAN SYNOVIAL CELLS

1988 • 87 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

Interleukin‐1 (IL‐1) receptor blockade reduces endotoxin and Borrelia burgdorferi ‐stimulated IL‐8 synthesis in human mononuclear cells

1992 • 85 citations

Interleukin-1β stimulates phospholipase A2 mRNA synthesis in rabbit articular chondrocytes

1989 • 84 citations

The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats

1993 • 80 citations

Immunopathology and cytokine detection in the skin lesions of patients with kawasaki disease

1993 • 77 citations

Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization.

1988 • 75 citations

IL-1 induces rapid phosphorylation of the IL-1 receptor.

1989 • 74 citations

Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.

1990 • 69 citations

Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.

1993 • 67 citations

Epidermal Interleukin-1 is Increased in Cutaneous T-Cell Lymphoma

1988 • 62 citations

IL-1α gene expression and protein production by fibroblasts from patients with systemic sclerosis

1994 • 61 citations

Interleukin‐1α gene expression and localization of interleukin‐1α protein during tumor promotion

1993 • 59 citations

Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.

1988 • 57 citations

Post-translational regulation of interleukin 1β secretion

1993 • 56 citations

Biology of the Interleukin-1 Receptor

1990 • 53 citations

Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts.

1993 • 53 citations

Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens.

1994 • 52 citations

Structure and function of the intracellular portion of the mouse interleukin 1 receptor (type I). Determining the essential region for transducing signals to activate the interleukin 8 gene

1993 • 49 citations

Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.

1995 • 49 citations

Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes

1988 • 47 citations

Cytokines and dexamethasone modulation of IL-1 receptors on human neutrophils in vitro.

1993 • 41 citations

Modulation of interleukin‐1α mRNA expression in mouse epidermis by tumor promoters and antagonists

1993 • 41 citations

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice.

1994 • 39 citations

Interleukin‐1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts

1989 • 38 citations

Platelet-derived growth factor induces interleukin-1 receptor gene expression in Balb/c 3T3 fibroblasts

1989 • 36 citations

Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation

1993 • 32 citations

Murine T helper cell-2 lymphocytes express type I and type II IL-1 receptors, but only the type I receptor mediates costimulatory activity.

1993 • 30 citations

Activation of IL 1-dependent and IL 1-independent T cell lines by calcium ionophore and phorbol ester.

1986 • 26 citations

Human aortic endothelial cells express the type I but not the type II receptor for interleukin‐1 (IL‐1)

1992 • 25 citations

Immunohistochemical Localization of Cytokines in Nevi

1992 • 22 citations

Interaction of recombinant monocyte-derived interleukin 1 receptor antagonist with rheumatoid synovial cells

1991 • 21 citations

Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators

1992 • 21 citations

A chimeric type II/type I interleukin-1 receptor can mediate interleukin-1 induction of gene expression in T cells

1993 • 20 citations

Hematopoietic growth factors upregulate the p65 type II interleukin-1 receptor on bone marrow progenitor cells in vitro

1992 • 18 citations

A signal peptide-independent protein secretion pathway

1992 • 9 citations

Chromosomal mapping of the human interleukin-1 receptor antagonist gene (IL-1RN) and isolation of specific YAC clones

1993 • 5 citations

Heterogeneity of type-II interleukin-1 receptors heterogeneity of B-cell interleukin-1 binding created by dimerization of type-II interleukin-1 receptors

1993 • 2 citations