Lipopolysaccharide-Induced NF-κB Activation in Mouse 70Z/3 Pre-B Lymphocytes Is Inhibited by Mevinolin and 5′-Methylthioadenosine: Roles of Protein Isoprenylation and Carboxyl Methylation Reactions

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Posttranslational modification of proteins by isoprenoids in mammalian cells

1990 • 515 citations

Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.

1978 • 489 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element.

1988 • 275 citations

Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine

1982 • 252 citations

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

1990 • 230 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis.

1990 • 173 citations

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

1990 • 150 citations

Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.

1991 • 149 citations

Pertussis Toxin Inhibition of B Cell and Macrophage Responses to Bacterial Lipopolysaccharide

1986 • 140 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

Interleukin 1-mediated induction of kappa-light chain synthesis and surface immunoglobulin expression on pre-B cells.

1984 • 134 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Ontogeny of murine B lymphocytes: sequence of B-cell differentiation from surface-immunoglobulin-negative precursors to plasma cells.

1976 • 110 citations

A labile inhibitor blocks immunoglobulin kappa-light-chain-gene transcription in a pre-B leukemic cell line.

1986 • 109 citations

Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line.

1984 • 102 citations

B‐Lymphocyte Signal Transduction in Response to Anti‐Immunoglobulin and Bacterial Lipopolysaccharide

1987 • 95 citations

Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

1989 • 89 citations

Induction of κ Transcription by Interferon-γ Without Activation of NF-κB

1988 • 75 citations

Lamin B methylation and assembly into the nuclear envelope

1989 • 70 citations

Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein

1990 • 63 citations

[29] The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis

1984 • 55 citations

Generation and characterization of hamster-mouse hybridomas secreting monoclonal antibodies with specificity for lipopolysaccharide receptor.

1990 • 53 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations

Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5′-Methylthioadenosine

1980 • 41 citations

Cellular distribution of cholesterogenesis‐linked, phosphoisoprenylated proteins in proliferating cells

1989 • 40 citations

The role of 5′-methylthioadenosine phosphorylase in 5′-methylthioadenosine-mediated inhibition of lymphocyte transformation

1979 • 38 citations

Inhibition of RNA synthesis in salivary glands of by 5′-methylthioadenosine

1976 • 20 citations

Effect of 5'‐methylthioadenosine on in vivo methyl esterification of human erythrocyte membrane proteins

1981 • 19 citations

Inhibition of lymphocyte cyclic AMP phosphodiesterase and lymphocyte function by 5′-methylthioadenosine

1982 • 15 citations

Effect of 5′‐methylthioadenosine on gene action during heat shock in Drosophila melanogaster

1979 • 13 citations

Effect of 5′‐Methylthioadenosine, 3‐Deazaadenosine, and Related Compounds on Human Natural Killer Cell Activity

1984 • 11 citations